Fatal attraction: Ventral striatum predicts costly choice errors in humans

Chumbley, Justin R.; Tobler, Philippe N.; Fehr, Ernst

doi:10.1016/j.neuroimage.2013.11.039

Cited by 8 publications

(4 citation statements)

References 47 publications

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“…3), being more specifically recruited when participants performed an action (e.g., pressing a button) in response to cues predicting reward (O'Doherty et al 2004;Tricomi et al 2004). While dorsal striatum activity has been linked to the encoding of action values used in action selection during reward-seeking behaviors (FitzGerald et al 2012), ventral striatum activity has been shown to correlate with participant's passive viewing responses to conditioned stimuli (Chumbley et al 2014). This observation is in line with the actor-critic model (Sutton and Barto 1998), suggesting that the dorsal striatum can serve a potential function of an "actor" that facilitates action selection, whereas the ventral striatum can serve as a "critic" to guide future reward attainment (O'Doherty et al 2004).…”

Section: Using Fmri To Study Reward Processing In the Striatummentioning

confidence: 99%

Using fMRI to study reward processing in humans: past, present, and future

Wang

Smith

Delgado

2016

Journal of Neurophysiology

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Functional magnetic resonance imaging (fMRI) is a noninvasive tool used to probe cognitive and affective processes. Although fMRI provides indirect measures of neural activity, the advent of fMRI has allowed for1) the corroboration of significant animal findings in the human brain, and2) the expansion of models to include more common human attributes that inform behavior. In this review, we briefly consider the neural basis of the blood oxygenation level dependent signal to set up a discussion of how fMRI studies have applied it in examining cognitive models in humans and the promise of using fMRI to advance such models. Specifically, we illustrate the contribution that fMRI has made to the study of reward processing, focusing on the role of the striatum in encoding reward-related learning signals that drive anticipatory and consummatory behaviors. For instance, we discuss how fMRI can be used to link neural signals (e.g., striatal responses to rewards) to individual differences in behavior and traits. While this functional segregation approach has been constructive to our understanding of reward-related functions, many fMRI studies have also benefitted from a functional integration approach that takes into account how interconnected regions (e.g., corticostriatal circuits) contribute to reward processing. We contend that future work using fMRI will profit from using a multimodal approach, such as combining fMRI with noninvasive brain stimulation tools (e.g., transcranial electrical stimulation), that can identify causal mechanisms underlying reward processing. Consequently, advancements in implementing fMRI will promise new translational opportunities to inform our understanding of psychopathologies.

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Section: Using Fmri To Study Reward Processing In the Striatummentioning

confidence: 99%

Using fMRI to study reward processing in humans: past, present, and future

Wang

Smith

Delgado

2016

Journal of Neurophysiology

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“…The greater the striatal response to monetary reward anticipation, the higher the positive affective response scores [56]. The greater the striatal response to cues paired with erotic images, the more likely these cues will be chosen two months later [57]. And the greater the striatal responses to images of food and sex, the greater the weight gain and sexual activity at follow-up six months later [58].…”

Section: Increased Impulsive Reward-seeking and Dopamine Responsivitymentioning

confidence: 99%

Dopamine ups and downs in vulnerability to addictions: a neurodevelopmental model

Leyton

Vezina

2014

Trends in Pharmacological Sciences

120

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Addictions are commonly presaged by problems in childhood and adolescence. For many individuals this starts with the early expression of impulsive risk-taking, social gregariousness and oppositional behaviors. We propose here that these early diverse manifestations reflect a heightened ability of emotionally salient stimuli to activate dopamine pathways that foster behavioral approach. If substance use is initiated, these at-risk youth can also develop heightened responses to drug-paired cues. Through conditioning and drug-induced sensitization, these effects strengthen and accumulate, leading to responses that exceed those elicited by other rewards. At the same time, cues not paired with drug become associated with comparatively lower dopamine release, accentuating further the difference between drug and non-drug rewards. Together, these enhancing and inhibiting processes steer a pre-existing vulnerability toward a disproportionate concern for drugs and drug-related stimuli. Implications for prevention and treatment are discussed.

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“…Inputting the within‐subject contrasts of the first‐level into the second‐level factorial design accounts for both within‐ and between‐subject variability, and thus our approach overall was one of a random‐effects GLM (Penny et al, 2007). This two‐level approach is commonly used, including by the authors of the software (SPM) used here (Chumbley et al, 2014; Henson & Penny, 2005). The factorial design specifications were implemented twice for each analysis.…”

Section: Methodsmentioning

confidence: 99%

Sign‐tracking modulates reward‐related neural activation to reward cues, but not reward feedback

Duckworth

Wright

Christiansen

et al. 2022

Eur J of Neuroscience

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Research shows cognitive and neurobiological overlap between sign-tracking [value-modulated attentional capture (VMAC) by response-irrelevant, discrete cues] and maladaptive behaviour (e.g. substance abuse). We investigated the neural correlates of sign-tracking in 20 adults using an additional singleton task (AST) and functional magnetic resonance imaging (fMRI). Participants responded to a target to win monetary reward, the amount of which was signalled by singleton type (reward cue: high value vs. low value). Singleton responses resulted in monetary deductions. Sign-tracking-greater distraction by high-value vs. low-value singletons (H > L)-was observed, with high-value singletons producing slower responses to the target than low-value singletons.Controlling for age and sex, analyses revealed no differential brain activity across H > L singletons. Including sign-tracking as a regressor of interest revealed increased activity (H > L singletons) in cortico-subcortical loops, regions associated with Pavlovian conditioning, reward processing, attention shifts and relative value coding. Further analyses investigated responses to reward feedback (H > L). Controlling for age and sex, increased activity (H > L reward feedback) was found in regions associated with reward anticipation, attentional control, success monitoring and emotion regulation. Including sign-tracking as a regressor of interest revealed increased activity in the temporal pole, a region related to value discrimination. Results suggest sign-tracking is associated with activation of the 'attention and salience network' in response to reward cues but not reward feedback, suggesting parcellation between the two at the level of the brain. Results add to the literature showing

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Fatal attraction: Ventral striatum predicts costly choice errors in humans

Cited by 8 publications

References 47 publications

Using fMRI to study reward processing in humans: past, present, and future

Using fMRI to study reward processing in humans: past, present, and future

Dopamine ups and downs in vulnerability to addictions: a neurodevelopmental model

Sign‐tracking modulates reward‐related neural activation to reward cues, but not reward feedback

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