Fatal Case of Congenital Plasma Thromboplastin Component Deficiency

Physiological Basis for Transfusion Therapy in Hemorrhagic Disorders: A Critical Review

“…The majority of mildly affected patients have similar symptoms and degrees of specific clotting factor deficiency,G and the amount of blood or plasma required to produce hemostasis appears to be equal to that required in factor VIII deficiency of the same degree of severity. 23 The factor IX concentration in most patients receiving oral anticoagulant therapy is usually not far below the "therapeutic range" of 15 to 25 per cent activity indicated by the Quick prothrombin test. 91 Bachmann,et ul.,11 found factor IX levels between 2 per cent and 10 per cent, while other factors were within the therapeutic range, in one-fourth of all patients who bled while on Marcoumar therapy.…”