Fatal community-acquired ribotype 002 Clostridium difficile bacteremia

Dauby, Nicolás; Libois, Agnès; Broeck, Johan Van; Delmée, Michel; Vandenberg, Olivier; Martiny, Delphine

doi:10.1016/j.anaerobe.2016.12.013

Cited by 11 publications

(7 citation statements)

References 12 publications

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“…These findings highlight possible discrepant epidemiologic etiologies of the infection at different locations ( 21 ). Recent emergence of C. difficile ribotype 002 in the region may also account for the discrepancy ( 15 , 22 , 23 ). This common circulating ribotype has a greater propensity to sporulate and produce toxins.…”

Section: Discussionmentioning

confidence: 99%

Disease Burden ofClostridium difficileInfections in Adults, Hong Kong, China, 2006–2014

Ho¹,

Dai²,

Kwong³

et al. 2017

Emerg. Infect. Dis.

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Cross-sectional studies suggest an increasing trend in incidence and relatively low recurrence rates of Clostridium difficile infections in Asia than in Europe and North America. The temporal trend of C. difficile infection in Asia is not completely understood. We conducted a territory-wide population-based observational study to investigate the burden and clinical outcomes in Hong Kong, China, over a 9-year period. A total of 15,753 cases were identified, including 14,402 (91.4%) healthcare-associated cases and 817 (5.1%) community-associated cases. After adjustment for diagnostic test, we found that incidence increased from 15.41 cases/100,000 persons in 2006 to 36.31 cases/100,000 persons in 2014, an annual increase of 26%. This increase was associated with elderly patients, for whom incidence increased 3-fold over the period. Recurrence at 60 days increased from 5.7% in 2006 to 9.1% in 2014 (p<0.001). Our data suggest the need for further surveillance, especially in Asia, which contains ≈60% of the world’s population.

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Section: Discussionmentioning

confidence: 99%

Disease Burden ofClostridium difficileInfections in Adults, Hong Kong, China, 2006–2014

Ho¹,

Dai²,

Kwong³

et al. 2017

Emerg. Infect. Dis.

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“…Mattila et al did a single-centre study over 10-year period and only 0.17% of the cases were reported to be extraintestinal 13. As reported in this study, 81% of the cases were inpatient and had received antibiotics which increased the risk of infection.…”

Section: Discussionmentioning

confidence: 46%

Invading beyond bounds: extraintestinalClostridium difficileinfection leading to pancreatic and liver abscesses

2017

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has become a common healthcare-associated infection over the past few years and gained more attention. was estimated to cause almost half a million infections in USA in 2011 and 29 000 died within 30 days of the initial diagnosis. Although colitis due to is the most common presentation, there have been reported cases of extraintestinal infections. As per our review of literature, this is the third reported case of liver abscess due to the organism.

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“…With the findings of sigmoid perforation, they considered the route of infection being translocation of bacteria across the gastrointestinal lumen due to colonic inflammation with direct seeding to the site. Direct spread of Cd from the intestine has been reported in previous case reports as well, where intra-abdominal spread of infection was suspected due to transient bacteremia in a case of alcoholic cirrhosis, with Cd isolated from ascites fluid, but in this patient, blood cultures remained negative [28]. Cd is rarely identified as a cause of pyogenic liver abscess, there are only three reported case of liver abscesses due to Cd, Sakurai et al [29] and Ulger et al [30] have reported liver abscess due to the organism.…”

Section: Discussion and Review Of The Literaturementioning

confidence: 53%

“…Cd bacteremia was also noted in a female patient (suffering from leukemia), lacking classical gastrointestinal symptoms or radiological findings of colitis or any ongoing gastrointestinal pathology [34]. Dauby et al recently reported a case of monomicrobial bacteremia due to Cd and identified the strain as ribotype 002 [28]. Cd bacteremia has been reported in 27 adult patients with gastrointestinal disease since 2011 and most of these cases involved polymicrobial bacteremia [32][33][34][35].…”

Section: Discussion and Review Of The Literaturementioning

confidence: 99%

Extraintestinal Clostridioides difficile Infections: Epidemiology in a University Hospital in Hungary and Review of the Literature

2020

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Extraintestinal manifestations of Clostridioides difficile infections (CDIs) are very uncommon, and according to the literature, poor outcomes and a high mortality have been observed among affected individuals. The objective of this study was to investigate the incidence rate of extraintestinal infections caused by C. difficile (ECD) in a tertiary-care university hospital in Hungary. During a 10-year study period, the microbiology laboratory isolated 4129 individual strains of C. difficile; among these, the majority were either from diarrheal fecal samples or from colonic material and only n = 24 (0.58%) were from extraintestinal sources. The 24 extraintestinal C. difficile isolates were recovered from 22 patients (female-to-male ratio: 1, average age: 55.4 years). The isolates in n = 8 patients were obtained from abdominal infections, e.g., appendicitis, rectal abscess or Crohn’s disease. These extraintestinal cases occurred without concomitant diarrhea. In all, but two cases C. difficile was obtained as a part of a polymicrobial flora. Our isolates were frequently toxigenic and mostly belonged to PCR ribotype 027. Resistance to metronidazole, vancomycin, clindamycin and rifampin were 0%, 0%, 20.5% and 9.7%, respectively. The increasing amount of reports of C. difficile extraintestinal infections should be noted, as these infections are characterized by a poor outcome and high mortality rate.

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Fatal community-acquired ribotype 002 Clostridium difficile bacteremia

Cited by 11 publications

References 12 publications

Disease Burden ofClostridium difficileInfections in Adults, Hong Kong, China, 2006–2014

Disease Burden ofClostridium difficileInfections in Adults, Hong Kong, China, 2006–2014

Invading beyond bounds: extraintestinalClostridium difficileinfection leading to pancreatic and liver abscesses

Extraintestinal Clostridioides difficile Infections: Epidemiology in a University Hospital in Hungary and Review of the Literature

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