Fatal cowpox-like virus infection transmitted by cat

The Pathology of Experimental Poxvirus Infection in Common Marmosets (Callithrix jacchus): Further Characterization of a New Primate Model for Orthopoxvirus Infections

“…The clinical and pathological features of the disease in marmosets were comparable in many aspects to human VARV infection ( [Fenner et al, 1988] and [Esposito and Fenner, 2001]). Different clinical manifestations of VARV infection are reported.…”

“…As natural VARV transmission is primarily by aerosol, we sought to investigate natural routes of infection (Esposito and Fenner, 2001). The main route of virus transmission via the respiratory tract was mimicked by IN application of the virus.…”

“…The majority of human CPXV and MPXV infections have a mild course, leading to localized, often selflimiting skin lesions with low morbidity (Campe et al, 2009). However, hospitalization of CPXVinfected individuals is reported and immunosuppressed individuals are at particular risk of developing severe complications, including disseminated infection and death ( [Eis-Hübinger et al, 1990] and [Czerny et al, 1991]). …”

Rat-to-Elephant-to-Human Transmission of Cowpox Virus

“…Human CPXV infections are commonly described in relation to contact with diseased domestic cats, rarely directly from rats (2,4). Human infections usually remain localized and self-limiting but can become fatal in immunosuppressed patients (5). CPXV infections in captive exotic animals have been reported to be transmitted by rodents (2,6).…”

When good vaccines go wild: Feral Orthopoxvirus in developing countries and beyond

“…Later, using molecular approaches, the identification and characterization of the virus became more accurate [98,109,[111][112][113][114][115][116]. It is important to emphasize that in eczematous or immunosuppressed individuals, cowpox virus can cause a severe to fatal infection [95,[117][118][119].…”