Fatal dengue hemorrhagic fever in Cuba, 1997

Guzmán, María G.; Álvarez, Mayling; Rodríguez, R; Rosario, Delfina; Vázquez, Susana; Valdés, Luís; Cabrera, María V.; Kourı́, Gustavo

doi:10.1016/s1201-9712(99)90033-4

Cited by 139 publications

(153 citation statements)

References 17 publications

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“…11,20 Fifteen (25%) of the DHF/DSS cases were in patients 15 years of age or older; other studies of dengue in the Americas also report similar findings. [21][22][23][24] Presumably, this is because in the Americas dengue is not yet hyperendemic, with all four serotypes circulating concurrently, as it is in Southeast Asia; thus, older adolescents and adults are still susceptible to new serotypes of virus. 25 In Nicaragua, dengue has maintained an endemic-epidemic pattern, with each epidemic associated with a dominant serotype and generally no more than two serotypes co-circulating.…”

Section: Discussionmentioning

confidence: 99%

Clinical, epidemiologic, and virologic features of dengue in the 1998 epidemic in Nicaragua.

Harris¹,

Videa²,

Pérez³

et al. 2000

Am J Trop Med Hyg

262

206

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Abstract. From July to December 1998, a hospital-and health center-based surveillance system for dengue was established at selected sites in Nicaragua to better define the epidemiology of this disease. Demographic and clinical information as well as clinical laboratory results were obtained, and virus isolation, reverse transcriptase-polymerase chain reaction, and serologic assays were performed. World Health Organization criteria were used to classify disease severity; however, a number of patients presented with signs of shock in the absence of thrombocytopenia or hemoconcentration. Therefore, a new category was designated as ''dengue with signs associated with shock'' (DSAS). Of 1,027 patients enrolled in the study, 614 (60%) were laboratory-confirmed as positive cases; of these, 268 (44%) were classified as dengue fever (DF); 267 (43%) as DF with hemorrhagic manifestations (DFHem); 40 (7%) as dengue hemorrhagic fever (DHF); 20 (3%) as dengue shock syndrome (DSS); and 17 (3%) as DSAS. Interestingly, secondary infection was not significantly correlated with DHF/DSS, in contrast to previous studies in Southeast Asia. DEN-3 was responsible for the majority of cases, with a minority due to DEN-2; both serotypes contributed to severe disease. As evidenced by the analysis of this epidemic, the epidemiology of dengue can differ according to geographic region and viral serotype.

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Section: Discussionmentioning

confidence: 99%

Clinical, epidemiologic, and virologic features of dengue in the 1998 epidemic in Nicaragua.

Harris¹,

Videa²,

Pérez³

et al. 2000

Am J Trop Med Hyg

262

206

View full text Add to dashboard Cite

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“…After an incubation period permitting virus replication, viral identification is performed using dengue-specific monoclonal antibodies in immunofluorescence and PCR assays 63,64,72,73 . Serum is often used for virus isolation but plasma, leukocytes, whole blood and tissues obtained at autopsy can also be used 63,74,75 . …”

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confidence: 99%

Dengue: a continuing global threat

et al. 2010

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Dengue fever and dengue haemorrhagic fever are important arthropod-borne viral diseases. Each year, there are ~50 million dengue infections and ~500,000 individuals are hospitalized with dengue haemorrhagic fever, mainly in Southeast Asia, the Pacific and the Americas. Illness is produced by any of the four dengue virus serotypes. A global strategy aimed at increasing the capacity for surveillance and outbreak response, changing behaviours and reducing the disease burden using integrated vector management in conjunction with early and accurate diagnosis has been advocated. Antiviral drugs and vaccines that are currently under development could also make an important contribution to dengue control in the future.Dengue is the most important arthropod-borne viral infection of humans. Worldwide, an estimated 2.5 billion people are at risk of infection, approximately 975 million of whom live in urban areas in tropical and sub-tropical countries in Southeast Asia, the Pacific and the Americas 1 . Transmission also occurs in Africa and the Eastern Mediterranean, and rural Europe PMC Funders GroupAuthor Manuscript Nat Rev Microbiol. Author manuscript; available in PMC 2015 February 19. Published in final edited form as:Nat Rev Microbiol. 2010 December ; 8(12 0): S7-16. doi:10.1038/nrmicro2460. Europe PMC Funders Author ManuscriptsEurope PMC Funders Author Manuscripts communities are increasingly being affected. It is estimated that more than 50 million infections occur each year, including 500,000 hospitalizations for dengue haemorrhagic fever, mainly among children, with the case fatality rate exceeding 5% in some areas [1][2][3][4] . The geographical areas in which dengue transmission occurs have expanded in recent years (FIG. 1), and all four dengue virus serotypes (DENV-1-4) are now circulating in Asia, Africa and the Americas, a dramatically different scenario from that which prevailed 20 or 30 years ago (FIG. 2). The molecular epidemiology of these serotypes has been studied in an attempt to understand their evolutionary relationships 11 .This Review will provide an update on our understanding of the pathogenesis of this successful pathogen, how we diagnose and control infection and the progress that has been made in vaccine development. Dengue virus pathogenesisDengue viruses belong to the genus flavivirus within the Flaviviridae family. DENV-1-4 evolved in non-human primates from a common ancestor and each entered the urban cycle independently an estimated 500-1,000 years ago 12 . The virion comprises a spherical particle, 40-50 nm in diameter, with a lipopolysaccharide envelope. The positive singlestrand RNA genome (FIG. 3), which is approximately 11 kb in length, has a single open reading frame that encodes three structural proteins -the capsid (C), membrane (M) and envelope (E) glycoproteins -and seven non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5 [18][19][20] . ADE occurs when mononuclear phagocytes are infected through their Fc receptors by immune complexes that form between DE...

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“…Resaltan la hepatomegalia, esplenomegalia, dolor abdominal, vómitos, ascitis y derrame pleural, asi como la presencia en dos reportes, de anticuerpos neutralizantes positivos para un serotipo previo con cifras mayores del 90% (94,95). Otros signos y sintomas de importancia son: fiebre, cefalea, ileo paralítico, alteración del sensorio, signos de sangrado (erupción petequial, melena, hematemesis, sangrado vaginal, metrorragia, etc).…”

Section: Discussionunclassified

“…Los signos y síntomas previos o inminentes al DS mas frecuentemente descritos son los vómitos, el dolor abdominal, la caída súbita de la fiebre con sudoración, la agitación o el letargo (1,17,19,73,81,94). Sin embargo dolor toráxico, tos, disnea, hepatomegalia y hematemesis también han sido reportados como manifestaciones previas al choque de importancia en las series cubanas (17,81).…”

Section: Característicasunclassified

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Dengue clásico y hemorrágico: Una enfermedad reemergente y emergente en el Perú.

Várgas¹,

Plenge²,

Ognio

et al. 2013

Rev Med Hered

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El dengue, también conocido popularmente como “Fiebre quebrantahuesos” es la más importante enfermedad viral humana transmitida por vectores artrópodos del genero Aedes, principalmente A. aegypti (1,2). Esta se ha ido extendiendo a varios países alrededor del mundo, en especial a los de las regiones tropicales y subtropicales en donde es una amenaza para más de 2 500 millones de personas (2), por lo que en la actualidad se le considera como una de las principales enfermedades virales reemergentes y emergentes a escala mundial. La diseminación del dengue obedece a muchas causas: guerras, viajes, calentamiento global, migraciones, hacinamiento, crecimiento demográfico, urbanización descontrolada, deterioro de los sistemas de servicios de agua y su almacenaje inadecuado, así como, a la falta de políticas preventivas de salud pública en los últimos 30 años en la mayoría de los países afectados (3).

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Fatal dengue hemorrhagic fever in Cuba, 1997

Abstract: The clinical, pathologic, and laboratory features of 12 cases of fatal dengue hemorrhagic fever were reviewed. The results obtained demonstrate that adults with a primary dengue infection are at risk of developing the severe disease (DHF) if they are infected with a different serotype.

Cited by 139 publications

References 17 publications

Clinical, epidemiologic, and virologic features of dengue in the 1998 epidemic in Nicaragua.

Clinical, epidemiologic, and virologic features of dengue in the 1998 epidemic in Nicaragua.

Dengue: a continuing global threat

Dengue clásico y hemorrágico: Una enfermedad reemergente y emergente en el Perú.

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