Fatal disseminated angioinvasive Fusarium falciforme infection in a patient with acute myeloid leukaemia

Sj, Yun; Mg, Shin; C, Choi; Kim, Hyung Jun; Jb, Lee; Sj, Kim; Sc, Lee; Yh, Won

doi:10.1111/j.1365-2133.2007.08020.x

Cited by 7 publications

(2 citation statements)

References 9 publications

(11 reference statements)

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“…We identified 97 cases of invasive fusariosis from the literature published since 2000. 1 – 4 , 6 – 13 , 16 , 18 , 20 – 27 , 31 – 33 , 37 – 39 , 42 – 44 , 46 , 48 , 50 – 57 , 59 , 61 , 62 , 65 – 67 , 69 – 71 , 74 – 81 , 83 – 85 , 87 , 89 , 91 , 97 , 99 , 100 – 103 , 105 – 108 , 111 – 113 , 115 – 121 , 124 – 126 , 128 – 135 , 139 , 140 The patients’ mean age was 45 years (range, 3 mo to 85 yr). Fifty-four patients were male and 41 female (sex was not reported in 2 cases).…”

Section: Resultsmentioning

confidence: 99%

Fusarium Infection

Muhammed¹,

Anagnostou²,

Desalermos³

et al. 2013

Medicine

138

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Fusarium species is a ubiquitous fungus that causes opportunistic infections. We present 26 cases of invasive fusariosis categorized according to the European Organization for Research and Treatment of Cancer/Mycoses Study Group (EORTC/MSG) criteria of fungal infections. All cases (20 proven and 6 probable) were treated from January 2000 until January 2010. We also review 97 cases reported since 2000. The most important risk factors for invasive fusariosis in our patients were compromised immune system, specifically lung transplantation (n = 6) and hematologic malignancies (n = 5), and burns (n = 7 patients with skin fusariosis), while the most commonly infected site was the skin in 11 of 26 patients. The mortality rates among our patients with disseminated, skin, and pulmonary fusariosis were 50%, 40%, and 37.5%, respectively. Fusarium solani was the most frequent species, isolated from 49% of literature cases. Blood cultures were positive in 82% of both current study and literature patients with disseminated fusariosis, while the remaining 16% had 2 noncontiguous sites of infection but negative blood cultures. Surgical removal of focal lesions was effective in both current study and literature cases.Skin lesions in immunocompromised patients should raise the suspicion for skin or disseminated fusariosis. The combination of medical monotherapy with voriconazole or amphotericin B and surgery in such cases is highly suggested.

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Section: Resultsmentioning

confidence: 99%

Fusarium Infection

Muhammed¹,

Anagnostou²,

Desalermos³

et al. 2013

Medicine

138

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“…Alguns pacientes podem apresentar lesões bolhosas. Em caso de plaquetopenia associada, algumas lesões podem se tornar hemorrágicas 1,5,6,9 .…”

Section: Discussionunclassified

Infecção Fatal Por Fusarium Em Criança Imunodeprimida

Marinho¹,

Silva²,

Avelleira³

et al. 2013

SPDV

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As infecções fúngicas representam uma importante complicação em pacientes imunocomprometidos e estão associadas com alta morbidade e mortalidade. As infecções por Fusarium têm sido relatadas com elevada frequência e podem ser localizadas, localmente invasivas ou disseminadas, dependendo do estado imunológico do hospedeiro. Os autores relatam o caso de um menino de quatro anos de idade, com leucemia linfóide aguda, em tratamento quimioterápico, que apresentou múltiplas lesões nodulares eritematosas que evoluíram para bolhas e necrose central. As culturas de conteúdo das bolhas atestaram crescimento de Fusarium spp. Apesar de tratamento com complexo lipídico de anfotericina B e voriconazol endovenosos, a criança evoluiu para óbito após 10 dias do surgimento das lesões cutâneas.PALAVRAS-CHAVE – Criança; Fusarium; Fusariose; Imunodeprimido, Leucemia Linfóide.

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