Fatal Echovirus Type 11 Infections

Halfon, Neal

doi:10.1001/archpedi.1981.02130350021008

Cited by 12 publications

(11 citation statements)

References 21 publications

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“…69,133). CNS disease sometimes occurs as a part of disseminated enteroviral infection, with viremia and involvement of heart, liver, kidneys, adrenal glands, and the blood coagulation system (14,26,56,71,75,77 Approximately 3,200 to 12,700 cases of aseptic meningitis were reported annually to the Centers for Disease Control between 1973 and 1983 (24), but its actual incidence is probably severalfold higher. Enteroviruses account for the majority of the identified agents causing aseptic meningitis, and yearly peak occurrences of the disease closely coincide with periods of most frequent enterovirus isolation (20,24).…”

Section: Enterovirusesmentioning

confidence: 99%

Role of the virology laboratory in diagnosis and management of patients with central nervous system disease

1989

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A number of viruses cause acute central nervous system disease. The two major clinical presentations are aseptic meningitis and the less common meningoencephalitis. Clinical virology laboratories are now more widely available than a decade ago; they can be operated on a modest scale and can be tailored to the needs of the patients they serve. Most laboratories can provide diagnostic information on diseases caused by enteroviruses, herpesviruses, and human immunodeficiency virus. Antiviral therapy for herpes simplex virus is now available. By providing a rapid diagnostic test or isolation of the virus or both, the virology laboratory plays a direct role in guiding antiviral therapy for patients with herpes simplex encephalitis. Although there is no specific drug available for enteroviruses, attention needs to be paid to these viruses since they are the most common cause of nonbacterial meningitis and the most common pathogens causing hospitalization for suspected sepsis in young infants in the United States during the warm months of the year. When the virology laboratory maximizes the speed of viral detection or isolation, it can make a significant impact on management of these patients. Early viral diagnosis benefits patients with enteroviral meningitis, most of whom are hospitalized and treated for bacterial sepsis or meningitis or both; these patients have the advantage of early withdrawal of antibiotics and intravenous therapy, early hospital discharge, and avoidance of the risks and costs of unnecessary tests and treatment. Enteroviral infection in young infants also is a risk factor for possible long-term sequelae. For compromised patients, the diagnostic information helps in selecting specific immunoglobulin therapy. Good communication between the physician and the laboratory will result in the most benefit to patients with central nervous system viral infection.

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Section: Enterovirusesmentioning

confidence: 99%

Role of the virology laboratory in diagnosis and management of patients with central nervous system disease

1989

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“…These viruses are known to infect skeletal and cardiac muscles, and may persist chronically in these tissues 10 11 12 13. Careful screening of the nerve plexuses in the viable intestinal segments showed no obvious viral protein staining or necrosis.…”

Section: Discussionmentioning

confidence: 99%

Intestinal intussusception in adults due to acute enterovirus infection

Chia

2009

J Clin Pathol

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Three adult cases of intussusceptions, associated with enteroviruses occurring within a 3-week period, are reported. Virological studies include viral RNA detection in stool samples and staining for enterovirus protein by immunoperoxidase staining of the resected intestinal tissues. A new mechanism for intussusception associated with enterovirus is proposed. Tap water was implicated in the outbreak. Better monitoring of drinking-water may prevent other cases of non-polio enterovirus infection.

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“…Enteroviruses cause a spectrum of manifestations in neonates, from asymptomatic infection to severe, fulminant, sometimes fatal diseases. Among the series of newborns with enterovirus‐associated clinical illness, fatality rates of 0−42% have been reported 3−13 . Death is often associated with the presence of myocarditis or hepatitis.…”

Section: Discussionmentioning

confidence: 99%

“…However, we experience many cases where the pathogen is not found despite careful examination for hepatitis virus. Enterovirus is one of the most common viruses of meningitis in very young infants 1 and is also known to cause fulminant hepatitis in newborn infants 2−12 . Enteroviruses, which are subdivided into three poliovirus serotypes, 23 coxackievirus group A serotypes, six coxackievirus group B serotypes, 30 echo viruses serotypes and four numbered serotypes are currently recognized and can be divided to 68 subtypes 13 .…”

mentioning

confidence: 99%

“…Enterovirus is one of the most common viruses of meningitis in very young infants 1 and is also known to cause fulminant hepatitis in newborn infants. [2][3][4][5][6][7][8][9][10][11][12] Enteroviruses, which are subdivided into three poliovirus serotypes, 23 coxackievirus group A serotypes, six coxackievirus group B serotypes, 30 echo viruses serotypes and four numbered serotypes are currently recognized and can be divided to 68 subtypes. 13 There are consensus regions in the 5 ′ non-coding region within all subtypes.…”

mentioning

confidence: 99%

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