Fatal flecainide intoxication

Romain, Nathalie; Giroud, Christian; Michaud, Katarzyna; Augsburger, Marc; Mangin, Patrice

doi:10.1016/s0379-0738(99)00156-5

Cited by 35 publications

(13 citation statements)

References 9 publications

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“…Furthermore samples of seven autopsy cases from the Institute of Legal Medicine of Lausanne with a known history of clotiapine therapy or tested positive for clotiapine during our routine screening procedure [14] and one case of driving under the influence of drugs (DUID) were also added to this study.…”

Section: Samplesmentioning

confidence: 99%

“…Biological specimens taken during autopsy were submitted to the general unknown screening procedure of our laboratory which includes headspace GC-FID analysis for volatile substances, urine immunoassays, GC-MS urine screening without and with alkaline hydrolysis and acetylation, GC-MS and HPLC-DAD blood screening [14]. The results for all analysed body fluids and tissues by GC-NPD are listed in Table 3.…”

Section: Post-mortem Samples and Distributionmentioning

confidence: 99%

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Determination and distribution of clotiapine (Entumine®) in human plasma, post-mortem blood and tissue samples from clotiapine-treated patients and from autopsy cases

Sporkert¹,

Augsburger²,

Giroud³

et al. 2007

Forensic Science International

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Section: Samplesmentioning

confidence: 99%

Section: Post-mortem Samples and Distributionmentioning

confidence: 99%

Determination and distribution of clotiapine (Entumine®) in human plasma, post-mortem blood and tissue samples from clotiapine-treated patients and from autopsy cases

Sporkert¹,

Augsburger²,

Giroud³

et al. 2007

Forensic Science International

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“…A comprehensive drug screening was carried out in urine with a combination of immunoassays, colour tests and GC-MS methods according to our standard procedures [13]. Xenobiotics in whole blood were screened by HPLC-DAD using the UV-spectra library of Pragst et al [14].…”

Section: Biological Samplesmentioning

confidence: 99%

Death following acute poisoning by moclobemide

Giroud¹,

Horisberger²,

Eap

et al. 2004

Forensic Science International

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“…In toxic doses, hypotension arises rapidly, and the resulting reduction in hepatic and renal blood flow would decrease Flecainide elimination from blood [7]. Post-mortem blood concentration of 13 mg/L and 16.3 mg/L were reported in several studies following ingestion of Flecainide [8,9]. Overdosing can cause or worsen supraventricular or ventricular arrhythmias and cause heart failure.…”

mentioning

confidence: 99%

“…Overdosing can cause or worsen supraventricular or ventricular arrhythmias and cause heart failure. Overdosage by mouth should be treated by removing the drug from the stomach through lavage, followed by activated charcoal; haemodialysis or haemoperfusion are unlike to enhance elimination [7][8][9][10][11]. In this case, activated charcoal was administered to the patient.…”

mentioning

confidence: 99%

Flecainide in Cadaveric Blood and Tissues

Vezzoli¹,

Adelaide²,

Bernini³

2017

JPP

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Abstract:In this report, we described a death caused by a deliberate overdose of Flecainide acetate (Almarytm ® ), an antiarrhythmic agent. The patient had taken a box of 20 Almarytm ® 100 mg tablets. The Flecainide concentration found in the post-mortem cardiac blood was 10.16 mg/L. This concentration could not have been determined by post-mortem diffusion of the drug from gastric residue because the patient was previously given activated carbon during the emergency procedure. In fact, in the peripheral blood, the Flecainide concentration was 8.64 mg/L, therefore, this concentration is overlapping with the concentration in the cardiac blood; the gastric content was negative at the screening of Flecainide, while the liver tissue concentration of Flecainide was 59.6 mg/L and the bile concentration was 128 mg/L. The brain tissue concentration of Flecainide was 4.19 mg/L. In this case, the cause of death, excluding that toxicity was depending on post-mortem gastric diffusion of the drug, because of the absorbing activity of the administered carbon at the recovery.

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Fatal flecainide intoxication

Cited by 35 publications

References 9 publications

Determination and distribution of clotiapine (Entumine®) in human plasma, post-mortem blood and tissue samples from clotiapine-treated patients and from autopsy cases

Determination and distribution of clotiapine (Entumine®) in human plasma, post-mortem blood and tissue samples from clotiapine-treated patients and from autopsy cases

Death following acute poisoning by moclobemide

Flecainide in Cadaveric Blood and Tissues

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