FATAL FRESH FROZEN PLASMA INFUSION CONTAINING HPA‐1a ALLOANTIBODIES

Solenthaler,; Krauss,; Boehlen,; Köller,; Hug, Clemens; Lämmle, Bernhard

doi:10.1046/j.1365-2141.1999.01574.x

Cited by 11 publications

(9 citation statements)

References 6 publications

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“…Indeed, most cases of passive thrombocytopenia reported in the literature are secondary to the transfusion of blood products containing anti-HPA-1a antibodies. 2,4 However, one case of transient and moderately severe thrombocytopenia caused by passive transfusion of plasma containing anti-HPA-5b antibodies has been reported. 3 …”

Section: Discussionmentioning

confidence: 98%

“…1 These antibodies can persist several years and their transfusion may lead to passive alloimmune thrombocytopenia in the recipient. [2][3][4] Thrombocytopenia due to passive transfer of anti-HPA (usually anti-HPA-1a) alloantibodies represents a rare complication of plasma, red blood cells or whole blood transfusions. When these alloantibodies are adsorbed onto the patient's platelets after infusion they may lead to transient but severe thrombocytopenia.…”

Section: Introductionmentioning

confidence: 99%

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HPA-genotyping and antiplatelet antibodies in female blood donors

Boehlen¹,

Bulla²,

Michel³

et al. 2003

Hematol J

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Cases of passive alloimmune thrombocytopenia have been reported due to transfusions of blood products with antiplatelet antibodies. The aim of our study was to search for antiplatelet antibodies in HPA-homozygous blood donor women once pregnant and also to perform, in case of positivity, a retrospective analysis of platelet counts of the recipients of their blood products. HPA-1, -2, -3 and -5 genotyping were performed on 500 platelet donors (42% women). Circulating antiplatelet antibodies were screened for by MAIPA assay in 122 women who experienced at least one pregnancy and who were homozygous for either HPA-1a, -1b, -3a, -3b, -5a or -5b. None of the women homozygous for HPA-1 or -3 had circulating antiplatelet antibodies. In contrast, two of the 98 women homozygous for HPA-5a and one of the two women homozygous for HPA-5b had circulating antibodies. A retrospective analysis of the medical charts of the 37 recipients of 55 blood components from these three women showed no case of passive alloimmune thrombocytopenia. Our study indicates the presence of platelet-specific antibodies in 2.5% of HPA-homozygous female platelet donors who were previously pregnant. Although none of the recipients developed passive alloimmune thrombocytopenia, this aspect of blood transfusion safety should be addressed by a large prospective trial.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

HPA-genotyping and antiplatelet antibodies in female blood donors

Boehlen¹,

Bulla²,

Michel³

et al. 2003

Hematol J

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“…1–3 Transfusion-associated alloimmune thrombocytopenia occurs when a platelet antigen-negative donor is exposed to a common platelet antigen, for example, through pregnancy or prior transfusion, and forms an antibody. Transfusion of plasma-containing product from the sensitized donor into an antigen-positive recipient can result in sudden, severe thrombocytopenia.…”

Section: Introductionmentioning

confidence: 99%

Severe Thrombocytopenia in a Child Secondary to Passive Platelet Antibody Transfer from a Plasma Transfusion

Collins

Scott

Punzalan

2013

Journal of Pediatric Hematology/Oncology

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Though rare, passive transfer of platelet antibodies through blood products can result in thrombocytopenia, acute transfusion reactions and death. We report a case of severe alloimmune thrombocytopenia from a plasma transfusion. A post-liver transplant patient with a normal platelet count received fresh frozen plasma (FFP) prior to liver biopsy. Post-biopsy she developed cardiorespiratory distress, petechiae and severe thrombocytopenia (platelet count 2,000/μL). Her platelet count recovered to normal over one week. This diagnosis should be considered whenever an unexpected drop in the platelet count occurs after a plasma-rich transfusion. Conservative transfusion practices and more targeted donor screening may prevent similar events.

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“…Passive alloimmune thrombocytopenia was first reported in 1987 (Ballem et al, ), and the first fatal case was reported in 1999 (Solenthalar et al, ). A literature review performed by Pavenski et al .…”

mentioning

confidence: 99%

“…Passive alloimmune thrombocytopenia was first reported in 1987 (Ballem et al, 1987), and the first fatal case was reported in 1999 (Solenthalar et al, 1999). A literature review performed by Pavenski et al (2008) identified 19 reports of passive alloimmune thrombocytopenia; all of these cases were associated with female blood donors with a history of pregnancy (Pavenski et al 2008).…”

mentioning

confidence: 99%