Fatal fulminant cryptococcemia complicating sarcoidosis: Is it to be expected?

Posteraro, Brunella; Vacca, Katia; Celi, Massimiliano; Angelis, Giulia De; Vella, Antonietta; Sanguinetti, Maurizio; Posteraro, Brunella

doi:10.1016/j.mmcr.2018.08.006

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…niaid.nih.gov/sites/default/files/adccfinal.pdf), are on the rise. Cases of cryptococcosis in these patients are often difficult to diagnose due to the rarity and the different clinical manifestation of the disease (Pappas, 2013;George et al, 2018;Henao-Martìnez et al, 2018;Shuai et al, 2018;Wang et al, 2018;Hamdam et al, 2018;Morse et al, 2018;Florentino et al, 2018;Dioverti et al, 2018;Yamada et al, 2018;Swan and Gottlieb, 2018;Posteraro et al, 2018). Furthermore, cryptococcosis can also occur in immunocompetent hosts, especially when the infection is caused by C. gattii species complex VGI or VGII, making the diagnosis more complicated (Chen et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Genotypes and population genetics of cryptococcus neoformans and cryptococcus gattii species complexes in Europe and the mediterranean area

Cogliati

Desnos‐Ollivier

McCormick-Smith

et al. 2019

Fungal Genetics and Biology

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A total of 476 European isolates (310 Cryptococcus neoformans var. grubii, 150 C. neoformans var. neoformans, and 16 C. gattii species complex) from both clinical and environmental sources were analyzed by multi-locus sequence typing. Phylogenetic and population genetic analyses were performed. Sequence analysis identified 74 sequence types among C. neoformans var. neoformans (VNIV), 65 among C. neoformans var. grubii (56 VNI, 8 VNII, 1 VNB), and 5 among the C. gattii species complex (4 VGI and 1 VGIV) isolates. ST23 was the most frequent genotype (22%) among VNI isolates which were mostly grouped in a large clonal cluster including 50% of isolates. Among VNIV isolates, a predominant genotype was not identified. A high percentage of autochthonous STs were identified in both VNI (71%) and VNIV (96%) group of isolates. The 16 European C. gattii species complex isolates analyzed in the present study originated all from the environment and all belonged to a large cluster endemic in the Mediterranean area. Population genetic analysis confirmed that VNI group of isolates were characterized by low variability and clonal expansion while VNIV by a higher variability and a number of recombination events. However, when VNI and VNIV environmental isolates were compared, they showed a similar population structure with a high percentage of shared mutations and the absence of fixed mutations. Also linkage disequilibrium analysis reveals differences between clinical and environmental isolates showing a key role of PLB1 allele combinations in host infection as well as the key role of LAC1 allele combinations for survival of the fungus in the environment. The present study shows that genetic comparison of clinical and environmental isolates represents a first step to understand the genetic characteristics that cause the shift of some genotypes from a saprophytic to a parasitic life style.

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Section: Introductionmentioning

confidence: 99%

Genotypes and population genetics of cryptococcus neoformans and cryptococcus gattii species complexes in Europe and the mediterranean area

Cogliati

Desnos‐Ollivier

McCormick-Smith

et al. 2019

Fungal Genetics and Biology

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“…Cryptococcus has often been reported as a life-threatening complication of sarcoidosis [ 39 , 40 ] . However, the autopsy findings did not confirm the diagnosis of sarcoidosis.…”

Section: Discussionmentioning

confidence: 99%

Disseminated Cryptococcal Disease in A Patient With Chronic Chylothorax and a Pleurovenous Catheter, a Case Report With Autopsy Findings

Mundo

Berning

Koullias

et al. 2021

Open Forum Infectious Diseases

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Cryptococcus species are ubiquitous in the environment with a global distribution. Whilst causing disease predominantly in immunocompromised hosts such as those with advanced HIV, HIV-uninfected patients are increasingly recognized to be affected. The most common forms of infection are cryptococcal pneumonia and meningitis. HIV-uninfected patients and extrapulmonary infections have worse outcomes, likely due to delayed diagnosis and treatment. Cryptococcus infections involving chylothorax or chyloabdomen have rarely been reported in humans. We describe a case of fulminant disseminated cryptococcosis with fungemia, peritonitis, and empyema in a patient with chronic chylothorax treated with an indwelling pleurovenous shunt. Key autopsy findings included cryptococcal organisms identified on calcified lymphadenopathy, pleural adhesions, and pericardium. We discuss the importance of identifying patients with non-traditional risks factors for cryptococcal disease, such as lymphopenia and hypogammaglobulinemia, and the potential implications of pleurovenous catheters in Cryptococcus dissemination.

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Systematic review on Cryptococcus neoformans/Cryptococcus gattii species complex infections with recommendations for practice in health and care settings

Torre

Andrews

Hooker

et al. 2022

Clinical Infection in Practice

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Fatal fulminant cryptococcemia complicating sarcoidosis: Is it to be expected?

Cited by 3 publications

References 14 publications

Genotypes and population genetics of cryptococcus neoformans and cryptococcus gattii species complexes in Europe and the mediterranean area

Genotypes and population genetics of cryptococcus neoformans and cryptococcus gattii species complexes in Europe and the mediterranean area

Disseminated Cryptococcal Disease in A Patient With Chronic Chylothorax and a Pleurovenous Catheter, a Case Report With Autopsy Findings

Systematic review on Cryptococcus neoformans/Cryptococcus gattii species complex infections with recommendations for practice in health and care settings

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