Fatal fungaemia due to Cryptococcus albidus in an elderly diabetic woman presenting with pleural effusion

Rodríguez-Leguizamón, Giovanni; Coque-Burgos, Eliana; Espitia-Castro, Omar; Firacative, Carolina

doi:10.1590/s1678-9946202062034

Cited by 3 publications

(4 citation statements)

References 16 publications

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“…noteworthy that most of them are attributed to C. neoformans, with only two reported instances of naganishial pleural effusions. 6,7 Previous case reports indicated that cryptococcal pleural fluid analysis typically exhibits an exudative nature with lymphocyte predominance. 8,9 However, exudative pleural effusion with a lymphocytic predominance can be observed in various diseases.…”

Section: Discussionmentioning

confidence: 99%

“…Non‐ neoformans cryptococcal infections are increasingly observed in immunocompromised patients with impaired cell‐mediated immunity other than HIV/AIDS, especially organ transplant recipients 4 . Although pleural involvement in cryptococcal infections is a rare occurrence, with approximately only 50 cases documented in a literature, 5 it's noteworthy that most of them are attributed to C. neoformans , with only two reported instances of naganishial pleural effusions 6,7 …”

Section: Discussionmentioning

confidence: 99%

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A case of naganishial pleuritis in a kidney transplant recipient

Tassaneeyasin,

Eksombatchai,

Chantharit

et al. 2024

Respirology Case Reports

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The Naganishia species is a mycosis, previously classified as a non‐neoformans Cryptococcus species. The increased number of naganishial infections occurs predominantly in immunocompromised conditions, especially in people living with HIV with low CD4 cell count, primary immunodeficiencies, and iatrogenic immunosuppression. The lungs can serve as the primary site of infection, leading to various pulmonary manifestations. However, naganishial pleural effusions are unrecognized and challenged in diagnosis because of their presentation, which can mimic tuberculous pleural effusion. Herein, we report the case of a 53‐year‐old man who had undergone kidney transplantation for more than 2 years and presented with chest tightness and dyspnea. Computed chest tomography demonstrated left pleural nodules and pleural effusion, later confirmed as exudative pleural effusion with a lymphocyte predominance. Pleuroscopy revealed multiple small pleural nodules, and biopsies of these nodules were performed. Naganishia spp. was identified by the 18S rRNA sequencing technique.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A case of naganishial pleuritis in a kidney transplant recipient

Tassaneeyasin,

Eksombatchai,

Chantharit

et al. 2024

Respirology Case Reports

View full text Add to dashboard Cite

show abstract

“…N. albidus have a draft genome record in GenBank, which has not yet been updated in the KmerFinder database ( Vajpeyi and Chandran, 2016 ; Yong et al, 2016 ). Many reports showed the clinical importance of these species as opportunistic pathogens ( Ragupathi and Reyna, 2015 ; Aghaei Gharehbolagh et al, 2017 ; Choe et al, 2020 ; Rodriguez-Leguizamon et al, 2020 ); however, none of these less common C. neoformans has been reported from this region before.…”

Section: Discussionmentioning

confidence: 99%

“…Due to the availability and affordability of better-resolution molecular biology techniques, such as DNA sequencing, more reports of infections with previously less reported Cryptococcus species become more evident ( Yong et al, 2016 ; Pakshir et al, 2019 ; Mirpourian et al, 2021 ). Other less common opportunistic Cryptococcus species are becoming an important cause of serious infections such as peritonitis and fungaemia in immunocompromised patients ( Ragupathi and Reyna, 2015 ; Aghaei Gharehbolagh et al, 2017 ; Choe et al, 2020 ; Rodriguez-Leguizamon et al, 2020 ). These infections might not be an emerging infection; however, the availability of whole-genome sequence data and the availability of easy-to-use bioinformatics tools are helping medical microbiology laboratories to better detect and identify these opportunistic Cryptococcus species ( Vajpeyi and Chandran, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Cryptococcus neoformans and Other Opportunistic Cryptococcus Species in Pigeon Dropping in Saudi Arabia: Identification and Characterization by DNA Sequencing

et al. 2021

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The prevalent variants of Cryptococcus neoformans, and other Cryptococcus species in pigeon excreta in Western Region of Saudi Arabia were studied. Ninety pigeon dropping samples were plated directly on Niger seed agar, and suspected colonies were sequenced using Illumina MiSeq. Species identification was determined using sequence read mapping to reference genomes of the two C. neoformans variants. In addition, sequence reads were identified using the KmerFinder tool. internal transcribed spacer 2 in the rDNA was also used for fungal barcoding of none of the C. neoformans species using two fungal identification databases. Phylogeny was studied using CSI Phylogeny (Center for Genomic Epidemiology, Denmark). The C. neoformans var. grubii mitochondrion and chromosome 1 reference sequences (accession numbers NC_004336.1 and CP022321.1, respectively) were used for sequence comparison and variant calling. Fifteen Cryptococcus isolates were isolated, 11 were identified as C. neoformans var. grubii, and 4 were found to be other opportunistic Cryptococcus species. Phylogeny analysis of C. neoformans var. grubii isolates showed a high degree of similarity between the C. neoformans isolates especially at the mitochondrial genome level. This study supports the fact that pathogenic and opportunistic Cryptococcus species are prevalent in domestic bird excreta which is an easy source of infection in the susceptible population.

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Tremellomycetes isolated from organs of Columba livia

et al. 2022

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Brain, lungs and intestines of Columba livia captured in Brazil were analyzed for research of Tremellomycetes. Mycological culture presented the growth of colonies suggestive of Cryptococcus spp. in 11.60% (13/112) of the samples. Microscopy revealed capsulated yeast cells. Molecular analysis evidenced Papiliotrema flavescens, Naganishia diffluens, Filobasidium magnum, and Naganishia randhawae. Thermotolerance of Tremellomycetes isolates from brain and lung (n = 10) evidenced cell growth and viability at 37°C. At 42°C/24 h, these isolates showed viability, except for one P. flavescens isolate. Here, we report the first isolation of Tremellomycetes species from brain and lung of healthy C. livia.

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Fatal fungaemia due to Cryptococcus albidus in an elderly diabetic woman presenting with pleural effusion

Abstract: This is an open-access article distributed under the terms of the Creative Commons Attribution License.

Cited by 3 publications

References 16 publications

A case of naganishial pleuritis in a kidney transplant recipient

A case of naganishial pleuritis in a kidney transplant recipient

Cryptococcus neoformans and Other Opportunistic Cryptococcus Species in Pigeon Dropping in Saudi Arabia: Identification and Characterization by DNA Sequencing

Tremellomycetes isolated from organs of Columba livia

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