Fatal Fusobacterium necrophorum infection with gynecological Lemierre's syndrome

Reymond, Barnabé; Huette, Pierre; Roger, Pierre-Alexandre; Trédez, Estelle; Gagneur, O.; Sanguin, Sophie; Guihéneuf, Raphaël; Dupont, Hervé; Mahjoub, Yazine; Abou-Arab, Osama

doi:10.1016/j.medmal.2018.09.006

Cited by 8 publications

(2 citation statements)

References 9 publications

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“…Fusobacterium necrophorum is a Gram-negative, anaerobic bacterium. F. necrophorum can cause necrotic and purulent diseases in cattle, sheep, pigs and humans (1)(2)(3)(4)(5). F. necrophorum mainly cause liver abscess in beef cattle and footrot in dairy cows.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Immunoprotective Effects of Fusobacterium necrophorum Outer Membrane Proteins 43K OMP, Leukotoxin and Hemolysin Multi-Component Recombinant Subunit Vaccine in Mice

Xiao

Jiang

et al. 2021

Front. Vet. Sci.

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We evaluated the efficacy of three vaccine formulations containing different combinations of proteins (43K OMP, leukotoxin recombinant protein PL4 and hemolysin recombinant protein H2) and killed whole cell Fusobacterium necrophorum in preventing liver abscess. Four subcutaneous vaccines were formulated: vaccine 1 (43K OMP), vaccine 2 (PL4 and H2), vaccine 3 (43K OMP, PL4 and H2), and vaccine 4 (killed whole bacterial cell). 43K OMP, PL4, and H2 proteins were produced by using recombinant protein expression. To evaluate vaccine efficacy, we randomly allocated 50 BALB/c female mice to one of five different treatment groups: PBS control group, vaccine 1, vaccine 2, vaccine 3, and vaccine 4. Mice were vaccinated three times, with 14 days between each immunization. After immunization, the mice were challenged with F. necrophorum. The three key findings of this study are as follows: (1) Vaccine 3 has enabled mice to produce higher antibody titer following bacterial challenge, (2) in the liver pathology of mice, the vaccine 3 liver showed the least pathology, and (3) all four vaccines produced high levels of antibodies and cytokines in mice, but the level of vaccine 3 was the highest. Based on our results, it has been demonstrated that a mixture of F. necrophorum 43K OMP, PL4, and H2 proteins inoculated with mice can achieve protection against liver abscess in mice. Our research may therefore provide the basis for the development of a vaccine against F. necrophorum bovine infections.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Immunoprotective Effects of Fusobacterium necrophorum Outer Membrane Proteins 43K OMP, Leukotoxin and Hemolysin Multi-Component Recombinant Subunit Vaccine in Mice

Xiao

Jiang

et al. 2021

Front. Vet. Sci.

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“…Abdominal symptoms have been commonly reported in patients with typical Lemierre syndrome initiated by a pharyngeal infection 2 5. However, primary infection sites can be found in the liver and be associated with portal vein thrombosis (pylephlebitis),8–10 or in gynaecological organs such as the vagina, cervix and uterus (with or without intrauterine device) and be associated with pelvic veins thrombosis 11–16. Although not specific, thrombocytopaenia, as observed in the present case, is a common feature of Lemierre syndrome 2 5.…”

Section: Differential Diagnosismentioning

confidence: 43%

Complex Lemierre syndrome with multisystemic abscesses

et al. 2023

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We present here the challenging case of severe Lemierre syndrome in a healthy woman in her late twenties, whose clinical presentation was characterised by lung abscesses and disseminated systemic abscesses in the brain, the abdomen and the soft-tissues, as a likely consequence of a patent foramen ovale. Blood cultures were positive forFusobacterium necrophorumand a right lingual vein thrombosis was detected at a late stage when the patient developed a septic shock. Initial antimicrobial therapy with metronidazole and ceftriaxone was modified to meropenem due to progressive worsening. The patient underwent laparoscopy and neurosurgical drainage of a cerebral abscess. She spent many days in the intensive care unit and recovered fully after 6 weeks on meropenem therapy. Although considered rare, the incidence of Lemierre syndrome, a potentially life-threatening condition, is increasing. The clinician should promptly recognise and treat it while being aware of its potential atypical presentations.

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Fatal Fusobacterium necrophorum infection with gynecological Lemierre's syndrome

Cited by 8 publications

References 9 publications

Evaluation of Immunoprotective Effects of Fusobacterium necrophorum Outer Membrane Proteins 43K OMP, Leukotoxin and Hemolysin Multi-Component Recombinant Subunit Vaccine in Mice

Evaluation of Immunoprotective Effects of Fusobacterium necrophorum Outer Membrane Proteins 43K OMP, Leukotoxin and Hemolysin Multi-Component Recombinant Subunit Vaccine in Mice

Complex Lemierre syndrome with multisystemic abscesses

Ibuprofen/norepinephrine

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