Fatal Human Case of Canigola Fever

Canicola Fever in Bristol

“…The prevalence of the condition in the Low Countries has been demonstrated by a number of workers since the species was first isolated there by Klarenbeek and Schuffner (1933), but its existence in this country has been appreciated only within recent years. We here record six cases to add to the six previously reported in Britain by Baber and Stuart (1946), Laurent et al (1948), and Weetch, Colquhoun, and Broom (1949). In two of our cases canicola fever was not diagnosed during the febrile attacks, and was suspected only when ocular complications supervened.…”

“…For example, the cases recorded by Baber and Stuart (1946) and by Mackay-Dick and Watts (1949) were apparently improved by penicillin, and the course of the disease in our third case may have been modified by the drug. On the other hand, the fatal case described by Weetch et al (1949) showed no response; though it should be noted that this patient died of uraemia, and that the leptospiral nephritis was superimposed on previously damaged kidneys, so that the effect of penicillin cannot be fully estimated. In Case 6 of our series, however, penicillin, begun on the fouirth day and continued for 14 days, did not prevent a recrudescence of fever during treatment.…”

Double-barrelled Enteric Intussusception Causing Volvulus

“…-Meningitis Due to Leptospira Canicola Since Leptospira canicola was first isolated in 1931 by Klarenbeek and Schiiffner (1933) from the urine of a dog, and the first cases of human infection were recorded by Dhont et al (1934), more than 150 cases have been reported (Alston, 1949). The first case in this country was recorded by Baber and Stuart (1946), and a number of cases have been reported since, several being of meiiingitic type and one only being fatal (Weetch et al, 1949).…”

Meningitis Due to Leptospira canicola

“…-Meningitis Due to Leptospira Canicola Since Leptospira canicola was first isolated in 1931 by Klarenbeek and Schiiffner (1933) from the urine of a dog, and the first cases of human infection were recorded by Dhont et al (1934), more than 150 cases have been reported (Alston, 1949). The first case in this country was recorded by Baber and Stuart (1946), and a number of cases have been reported since, several being of meiiingitic type and one only being fatal (Weetch et al, 1949).…”