Fatal<i>Acinetobacter baumanii</i>Necrotizing Fasciitis following Open Reduction Internal Fixation in a Polytrauma Patient

Nehme, Alexandre; Joukhadar, Nabih I.; Saidy, Elias; Darwiche, Mohammad; Aouad, Dany; Nour, Hicham G. Abdel

doi:10.1155/2018/4176320

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…A. baumannii in Lebanon was mostly implicated in ventilator associated pneumoniae [15,16], urinary tract, intra-abdominal, blood and wound infections [17][18][19]. Furthermore, unique cases of necrotizing fasciitis caused by multi-drug resistant A. baumannii were also reported [20,21]. In one of the aforementioned necrotizing fasciitis cases, the strain was only sensitive to amikacin and polymyxin, challenging therefore the available treatment [21].…”

Section: Acinetobacter Baumannii In Lebanon: a Real Threat Or An Overmentioning

confidence: 99%

Acinetobacter spp in a Third World Country with Socio-economic and Immigrants Challenges

Dandachi¹,

Azar²,

Hamouch³

et al. 2019

J Infect Dev Ctries

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Introduction: In the last decade, Acinetobacter species have taken a major public health concern. This is mainly due the increased resistance to a wide range of antibiotics causing treatment challenges. In view of the constant population mobilization and the economic crisis that Lebanon is currently facing, it becomes a necessity to re-evaluate the real threat of Acinetobacter spp and its implication in the one health. Methodology: This review was conducted through the analysis of 45 research papers and reports pertaining to Acinetobacter spp performed in Lebanon. More than 82% of the papers consulted were published in international journals and more than 70 percent of them had received impact factor. Results: An in depth description of the involvement of this organism in human infection and its role as potential pathogen or simple colonizer was performed. In addition, the different aspects of resistance, mostly to carbapenems and colistin was studied and summarized. While in animals and environment, susceptible strains were mostly isolated, OXA-23/OXA-24 were predominant in humans. Recently, NDM-1 producing Acinetobacter spp was detected in a Syrian refugee which then was reported in Lebanese patients. The bacterial identification procedures are non-systematic and not always reliable in the Lebanese studies presenting sometimes discrepancies an inconsistency. Conclusion: Acinetobacter is commonly isolated Lebanon. In view of the spread of resistance among these isolated and their dissemination, Infection control measures attempting to control the spread of this genus in and outside hospitals are lacking and thus require more attention and stewardship activities.

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Section: Acinetobacter Baumannii In Lebanon: a Real Threat Or An Overmentioning

confidence: 99%

Acinetobacter spp in a Third World Country with Socio-economic and Immigrants Challenges

Dandachi¹,

Azar²,

Hamouch³

et al. 2019

J Infect Dev Ctries

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“…In fact, one of the first confirmed cases in which A. baumannii was identified as the sole microbial cause of human necrotizing fasciitis was reported in 2009 (Charnot- Katsikas et al, 2009). Since then, at least ten more cases of human necrotizing fasciitis with A. baumannii as the sole etiological agent have been described in the literature (Corradino et al, 2010;Salvador et al, 2010;Sullivan et al, 2010;Wagner et al, 2011;Clemente et al, 2012;DeMuro et al, 2012;Hachimi et al, 2013;Oymacı et al, 2014;Sinha et al, 2014;Nehme et al, 2018;Rebai et al, 2018;Goret et al, 2019;Matthews et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Two Acinetobacter baumannii Isolates Obtained From a Fatal Necrotizing Fasciitis Infection Display Distinct Genomic and Phenotypic Characteristics in Comparison to Type Strains

Grier

Arivett

Ramírez

et al. 2021

Front. Cell. Infect. Microbiol.

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Acinetobacter baumannii has been recognized as a critical pathogen that causes severe infections worldwide not only because of the emergence of extensively drug-resistant (XDR) derivatives, but also because of its ability to persist in medical environments and colonize compromised patients. While there are numerous reports describing the mechanisms by which this pathogen acquires resistance genes, little is known regarding A. baumannii’s virulence functions associated with rare manifestations of infection such as necrotizing fasciitis, making the determination and implementation of alternative therapeutic targets problematic. To address this knowledge gap, this report describes the analysis of the NFAb-1 and NFAb-2 XDR isolates, which were obtained at two time points during a fatal case of necrotizing fasciitis, at the genomic and functional levels. The comparative genomic analysis of these isolates with the ATCC 19606T and ATCC 17978 strains showed that the NFAb-1 and NFAb-2 isolates are genetically different from each other as well as different from the ATCC 19606T and ATCC 17978 clinical isolates. These genomic differences could be reflected in phenotypic differences observed in these NFAb isolates. Biofilm, cell viability and flow cytometry assays indicate that all tested strains caused significant decreases in A549 human alveolar epithelial cell viability with ATCC 17978, NFAb-1 and NFAb-2 producing significantly less biofilm and significantly more hemolysis and capacity for intracellular invasion than ATCC 19606T. NFAb-1 and NFAb-2 also demonstrated negligible surface motility but significant twitching motility compared to ATCC 19606T and ATCC 17978, likely due to the presence of pili exceeding 2 µm in length, which are significantly longer and different from those previously described in the ATCC 19606T and ATCC 17978 strains. Interestingly, infection with cells of the NFAb-1 isolate, which were obtained from a premortem blood sample, lead to significantly higher mortality rates than NFAb-2 bacteria, which were obtained from postmortem tissue samples, when tested using the Galleria mellonella in vivo infection model. These observations suggest potential changes in the virulence phenotype of the A. baumannii necrotizing fasciitis isolates over the course of infection by mechanisms and cell processes that remain to be identified.

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FatalAcinetobacter baumaniiNecrotizing Fasciitis following Open Reduction Internal Fixation in a Polytrauma Patient

Cited by 2 publications

References 14 publications

Acinetobacter spp in a Third World Country with Socio-economic and Immigrants Challenges

Acinetobacter spp in a Third World Country with Socio-economic and Immigrants Challenges

Two Acinetobacter baumannii Isolates Obtained From a Fatal Necrotizing Fasciitis Infection Display Distinct Genomic and Phenotypic Characteristics in Comparison to Type Strains

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