Fatal <i><scp>H</scp>aemophilus influenzae</i> type a sepsis in an infant

Francis, Joshua; Anders, Marc; Lobegeier, Pam; Nourse, Clare

doi:10.1111/jpc.12031

Cited by 6 publications

(4 citation statements)

References 9 publications

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“…There are growing numbers of sporadic case reports, case series, and retrospective studies with various clinical presentations of invasive Hia infection globally. [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] Most of these reports show the greatest burden of invasive Hia disease in children ≤ 5 years or adults > 65 years, 32 with short-and long-term adverse outcomes exclusively in young children ≤ 5 years of age. 23,31,33 We described two cases of invasive Hia infection in children > 5 years of age who presented within a 2-month period to our hospital.…”

Section: Discussionmentioning

confidence: 99%

“…There are growing numbers of sporadic case reports, case series, and retrospective studies with various clinical presentations of invasive Hia infection globally. 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 Most of these reports show the greatest burden of invasive Hia disease in children ≤ 5 years or adults > 65 years, 32 with short‐ and long‐term adverse outcomes exclusively in young children ≤ 5 years of age. 23 , 31 , 33 …”

Section: Discussionmentioning

confidence: 99%

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Report of Haemophilus Influenzae serotype a intracranial infections in older children

Probst

Shahoud

Osborne

et al. 2023

Pediatric Investigation

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Introduction Haemophilus influenzae (Hi) is subdivided into typeable (a–f) and non‐typeable groups. Hi serotype b (Hib) has historically been one of the important pathogens responsible for invasive infection. However, after widespread Hib vaccination, the emergence of other Hi serotypes, specifically Hi serotype a (Hia), was noted during the last few decades, mostly in children younger than 5 years of age. Case presentation We present two cases of severe intracranial infections with detected Hia in patients > 5 years of age within a short time frame and within the same geographic area. Conclusion Epidemiological studies and surveillance on Hia‐related illnesses in all age groups worldwide are needed to better understand the clinical and epidemiological characteristics of Hia. This can establish a platform to develop a candidate vaccine against Hia that might protect children of all ages.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Report of Haemophilus Influenzae serotype a intracranial infections in older children

Probst

Shahoud

Osborne

et al. 2023

Pediatric Investigation

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“…Besides meningitis [26], Hia has been reported to cause sepsis with toxic shock [27], septic arthritis [28], soft tissue infection with pus and abscess [29], pneumonia with empyema [30], and epiglottitis [31]. Most invasive Hia cases occur in children between the ages of 6 months to 2 years [32; authors' unpublished data].…”

Section: Discussionmentioning

confidence: 99%

Recurrent invasive Haemophilus influenzae serotype a infection in an infant

Whyte¹,

Levett²,

Horsman³

et al. 2015

Microbiol Discov

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Background: Before introduction of conjugated Haemophilus influenzae serotype b (Hib) vaccines into the routine childhood immunization programs, Hib was a major cause of meningitis in infants and children under the age of 5. In the post-Hib vaccine era, the epidemiology of invasive H. influenzae has changed substantially with most invasive diseases now caused by non-Hib strains, including H. influenzae serotype a (Hia) and serotype f, as well as non-encapsulated or non-typeable strains. This case report describes the microbiology of Hia in a recurrent invasive infection in an infant. The Hia strain involved is described together with current knowledge of Hia infection including methods of protection. Methods: Isolates were characterised by Gram stain, growth factor requirements, biotype, serotype, detection of IS1016-bexA deletion, multilocus sequence typing, pulsed-field gel electrophoresis and antimicrobial susceptibility testing. Results: All three isolates appeared to be identical, belonged to biotype II, serotype a, sequence type 23, lacked the IS1016-bexA partial deletion, and were susceptible to commonly prescribed antibiotics tested. Conclusion: Hia has emerged as a significant invasive pathogen in the post Hib vaccine era. MLST and PFGE serve as useful techniques for typing of Hia. Many attributes of Hia and the disease it causes bear resemblance to Hib and Hib disease, including the ability to cause recurrent infections. This raises the potential for protection by vaccination and chemoprophylaxis.

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“…Isolates from blood and CSF. Francis et al (2011) [21] Hia from Western Australia 10-month-old male with septic shock. Isolate from blood.…”

Section: Discussionmentioning

confidence: 99%

Pediatric invasive disease due to Haemophilus influenzae serogroup A in Riyadh, Saudi Arabia: case series

Roaa

Abdulsalam

Shahid

et al. 2016

J Infect Dev Ctries

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We describe the first two cases of invasive disease caused by Haemophilus influenzae serotype A in Saudi Arabia. This is the first known reported invasive Haemophilus influenzae serotype A from Saudi Arabia. Case presentation: A ten-month-old and three-month-old male not known to have any past history of any medical illness and who had received H. influenzae type b (Hib) vaccine presented to our hospital mainly with fever of few days' duration. A provisional diagnosis of meningitis with sepsis was made and laboratory tests were requested. The chest radiograph was normal. The laboratory results revealed leukocytosis, but leukopenia was noticed in the younger infant. Blood culture and cerebrospinal fluid specimens yielded a pure culture of Haemophilus influenzae and serotyping showed the isolates to be serogroup A. Both patients were started on vancomycin and third-generation cephalosporin. On receiving the blood culture result, vancomycin was stopped. Fever subsided after 48 hours, while in the second case, it continued for 12 days from the admission date. The repeat blood cultures were negative. Antibiotic therapy was given for 10 days for the first case with an unremarkable hospital course, while the second case was complicated by seizure and received a longer duration of antibiotics. Both infants were discharged home in good condition. Conclusions: Invasive non-typeable H. influenzae strains are emerging and there is a need for surveillance of this disease. This has implications in future vaccine development.

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Fatal Haemophilus influenzae type a sepsis in an infant

Cited by 6 publications

References 9 publications

Report of Haemophilus Influenzae serotype a intracranial infections in older children

Report of Haemophilus Influenzae serotype a intracranial infections in older children

Recurrent invasive Haemophilus influenzae serotype a infection in an infant

Pediatric invasive disease due to Haemophilus influenzae serogroup A in Riyadh, Saudi Arabia: case series

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