Fatal <i>Yersinia enterocolitica</i> biotype 4 serovar O:3 sepsis after red blood cell transfusion

Leclercq, Alexandre; Martin, Liliane; Vergnes, Maya Laporte; Ounnoughène, N.; Laran, Jean-François; Giraud, P; Carniel, Élisabeth

doi:10.1111/j.1537-2995.2005.04363.x

Cited by 56 publications

(26 citation statements)

References 23 publications

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“…Two strains of type 2/O:9 (9%) and 4/O:3 (4%) were isolated from blood, showing that these bioserotypes are not uncommon causes of bacteraemia in humans. Y. enterocolitica was one of the first recognised causes of post-transfusion sepsis [13]. Serotypes O:3 and O:9 are the most common types attributed to post-transfusion septic shock.…”

Section: Discussionmentioning

confidence: 99%

Yersinia enterocolitica strains associated with human infections in Switzerland 2001–2010

Fredriksson-Ahomaa

Cernela

Hächler

et al. 2011

Eur J Clin Microbiol Infect Dis

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Yersinia enterocolitica infections are common in humans. However, very scarce data are available on the different biotypes and virulence factors of human strains, which has proved to be problematic to assess the clinical significance of the isolated strains. In this study, the presence of the ail gene and distribution of different bio- and serotypes among human Y. enterocolitica strains and their possible relation to the genotype and antimicrobial resistance were studied. In total, 128 Y. enterocolitica strains isolated from human clinical samples in Switzerland during 2001-2010 were characterised. Most (75 out of 128) of the Y. enterocolitica strains belonged to biotypes 2, 3 or 4 and carried the ail gene. One of the 51 strains that belonged to biotype 1A was also ail positive. Most of the ail-positive strains belonged to bioserotype 4/O:3 (47 out of 76) followed by 2/O:9 (22 out of 76). Strains of bioserotype 4/O:3 were dominant among patients between 20 and 40 years old and strains of biotype 1A dominate in patients over 40 years. Strains belonging to biotypes 2, 3 and 4, which all carried the ail gene, exhibited a high homogeneity with PFGE typing. Y. enterocolitica 2/O:5,27 and 2/O:9 strains showed resistance to amoxicillin/clavulanic acid and cefoxitin, but Y. enterocolitica 4/O:3 strains did not.

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Section: Discussionmentioning

confidence: 99%

Yersinia enterocolitica strains associated with human infections in Switzerland 2001–2010

Fredriksson-Ahomaa

Cernela

Hächler

et al. 2011

Eur J Clin Microbiol Infect Dis

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“…Concerning the safety of the blood, there is fear of possible contamination with siderophilic bacteria, such as Vibrio sp., Salmonella sp., and Yersinia sp. [7][8][9][10], especially as Yersinia enterocolitica has been identified with increased frequency as a causative agent of post-transfusion septic shock with possible fatal outcome [11]. Because iron overload can impair the host immune system, and viruses can interact with the iron metabolism to cause infection (e.g., by altering the expression of proteins involved in iron homeostasis), there is also a potential higher susceptibility for viral infections [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Is blood of uncomplicated hemochromatosis patients safe and effective for blood transfusion? A systematic review

Buck¹,

Pauwels²,

Dieltjens³

et al. 2012

Journal of Hepatology

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Hemochromatosis is a disorder of the iron metabolism, characterized by high body iron content, necessitating frequent phlebotomies to remove excess iron. In some countries, this blood is discarded and not used for blood transfusion because of the non-voluntary character of this donation, and because a potential risk of microbial contamination of the donor blood is assumed. A systematic review was performed in order to collect and critically examine solid evidence with regard to the effectiveness and safety of blood for transfusion when derived from hemochromatosis patients who do not suffer from complications or organ damage. Using three databases (The Cochrane Library, MEDLINE, and Embase) we searched for studies from date of inception until January 2012. Out of 3470 articles, 80 references that were relevant to our question were selected, including many opinion pieces, comments, letters, and narrative reviews. Based on our selection criteria, we finally retained only six observational studies, so evidence on this subject is scarce and furthermore, the strength of the available evidence is low to very low, due to poor study designs. We found no evidence that red blood cell concentrates from hemochromatosis patients without complications of iron overload do not comply with the physiological quality requirements for transfusion, nor that their blood would present a greater risk to recipient safety than blood from non-hemochromatosis donors. However, in vitro findings from two studies suggest that iron-overloaded patients would be more susceptible to bacterial growth, but future in vivo studies are warranted to confirm this. Based on this, we call for harmonization of the blood donor selection policy among countries allowing hemochromatosis patients who do not suffer from complications of iron overload to donate blood, once iron levels are normalized.

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“…hemochromatosis, complicating bacteremias with Yersinia and Vibrio species were described (7). The transfusion of blood stored for periods .3 wk, thus prone to hemolysis and excess free iron, has been complicated by Yersinia bacteremias (8). The high-pathogenicity island present in pathogenic Yersinia and encoding the siderophores, yersiniabactin, has recently been identified in various Escherichia coli pathotypes responsible for bacteremia and urosepsis (9).…”

Section: Pathogensmentioning

confidence: 99%

Host-Pathogen Interactions: The Role of Iron1,

Doherty¹

2007

The Journal of Nutrition

153

115

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Iron is essential for both host and pathogen, and complex systems of acquisition and utilization have evolved in competition.Our increasing knowledge of the basic mechanisms of homeostasis and their adaptation during deficiency, overload, and infection indicate that iron is a key regulator of host pathogen interactions. This review concentrated on the clinical and public health aspects of the interaction between the iron acquisition mechanisms of select pathogens of public health importance with host iron homeostasis. Knowledge of these interactions is essential in assessing likely morbidity responses to supplementation. J. Nutr. 137: 1341Nutr. 137: -1344Nutr. 137: , 2007

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Fatal Yersinia enterocolitica biotype 4 serovar O:3 sepsis after red blood cell transfusion

Cited by 56 publications

References 23 publications

Yersinia enterocolitica strains associated with human infections in Switzerland 2001–2010

Yersinia enterocolitica strains associated with human infections in Switzerland 2001–2010

Is blood of uncomplicated hemochromatosis patients safe and effective for blood transfusion? A systematic review

Host-Pathogen Interactions: The Role of Iron1,

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