Fatal Legionnaires' Disease Coincident With Initiation of Immunosuppressive Therapy

Sheldon, Peggy A.

doi:10.1001/archinte.1985.00360060206034

Cited by 10 publications

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our patient's case, broad-spectrum therapy failed to produce improvement in the cellulitis, and it was the patient's history of a prior episode of Legionellaassociated cellulitis that prompted the initiation of azithromycin with subsequent rapid clinical improvement. This case also illustrates that relapsing Legionella infection can occur in immunocompromised patients, even after prolonged therapy with highly active antimicrobials that ordinarily are curative after shorter durations of therapy [13,14].…”

Section: Discussionmentioning

confidence: 85%

Relapsing Legionella pneumophila cellulitis: a case report and review of the literature

Han

Nguyen

Harada

et al. 2010

Journal of Infection and Chemotherapy

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 85%

Relapsing Legionella pneumophila cellulitis: a case report and review of the literature

Han

Nguyen

Harada

et al. 2010

Journal of Infection and Chemotherapy

View full text Add to dashboard Cite

Protective Effects of Tumor Necrosis Factor in Experimental Legionella pneumophila Infections of Mice via Activation of PMN Function

Blanchard

Djeu

Klein

et al. 1988

Journal of Leukocyte Biology

129

View full text Add to dashboard Cite

Tumor necrosis factor (TNF) was found in the lung lavage fluids of Legionella pneumophila-infected mice within 24 hr of intratracheal (i.t.) inoculation. Since this cytokine has been reported to activate polymorphonuclear leukocyte (PMN) function, the effect of TNF on the in vitro bactericidal capacity of PMN-enriched cultures was determined. Murine thioglycollate-elicited PMN which were treated with recombinant human TNF demonstrated augmented killing of L. pneumophila bacteria in vitro. Furthermore, treatment of PMN suspensions with cytokine-containing lung lavage fluid was found to enhance the bactericidal activity of PMN. The addition of anti-cachectin/TNF antibodies partially abrogated the stimulatory effects of the lavage fluid, suggesting that in vivo activation of PMN during the course of infection was likely, and that TNF was partially responsible for the enhanced bactericidal activity. In vivo treatment of animals with TNF resulted in significant protection of the animals from mortality. Furthermore, the rate of clearance of bacteria from the lung tissues of infected mice was increased in those animals treated with TNF, and correlated with the ability of this cytokine to protect the animals. These data suggest that the induction of TNF by Legionella bacteria during infection are involved in the non-specific host defense mechanisms, and that PMN activated by the TNF may be instrumental in clearing the organism from infected lung tissues, thereby protecting the animal.

show abstract

Legionellosis in the Compromised Host

Ampel

Wing

1994

Clinical Approach to Infection in the Compromised Host

View full text Add to dashboard Cite

Fatal Legionnaires' Disease Coincident With Initiation of Immunosuppressive Therapy

Cited by 10 publications

References 6 publications

Relapsing Legionella pneumophila cellulitis: a case report and review of the literature

Relapsing Legionella pneumophila cellulitis: a case report and review of the literature

Protective Effects of Tumor Necrosis Factor in Experimental Legionella pneumophila Infections of Mice via Activation of PMN Function

Legionellosis in the Compromised Host

Contact Info

Product

Resources

About