Fatal methanol poisoning and organ donation: experience with seven cases in a single center

Hantson, Philippe; Vanormelingen, P; Lecomte, Christel; Dumont, V.; Squifflet, Jean‐Paul; Otte, Jean-Bernard; Mahieu, Paul

doi:10.1016/s0041-1345(00)00852-6

Cited by 23 publications

(6 citation statements)

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“…Subsequently, three case series of organ donation following methanol poisoning were reported [6,8,21]. The largest series involved a total of 38 transplanted organs (29 kidneys, four hearts and five livers) from 16 methanol-poisoned donors [8].…”

Section: Discussionmentioning

confidence: 99%

“…Although the kidney is among the main organs of toxicity, the first reported successful transplantation following methanol ingestion showed long-term survival of four transplanted kidneys [ 20 ]. Subsequently, three case series of organ donation following methanol poisoning were reported [ 6 , 8 , 21 ]. The largest series involved a total of 38 transplanted organs (29 kidneys, four hearts and five livers) from 16 methanol-poisoned donors [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

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Poisoned patients as potential organ donors: postal survey of transplant centres and intensive care units

2003

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BackgroundThe number of patients awaiting allograft transplantation in the UK exceeds the number of organs offered for transplantation each year. Most organ donors tend to be young, fit and healthy individuals who die because of trauma or sudden cardiac arrest. Patients who die from drug and poison intoxication tend to have similar characteristics but are less frequently offered as potential organ donors.MethodsA postal questionnaire survey of all transplantation centres and an equal number of intensive care units in the UK was undertaken. The use of kidney, heart, lung, liver and pancreas transplants from poisoned patients following deliberate methanol ingestion, cardiac arrest presumed secondary to cocaine overdose, accidental domestic carbon monoxide inhalation and industrial cyanide exposure were used as case scenarios.ResultsResponse rates were 70% for transplantation centres and 50% for intensive care unit directors. Over 80% of organs would be offered or discussed with transplant coordinators by intensive care unit directors. Transplantation physicians/surgeons would consider transplanting organs in up to 100% of case scenarios, depending on the organ and poisoning or intoxication involved.DiscussionThe postal survey presented here shows that most transplantation physicians and surgeons and intensive care unit directors would consider those who die following acute drug intoxication and poisoning as potential organ donors. The previously reported literature shows in general that transplanted organs from poisoned patients have good long-term survival, although the number of reports is small. Poisoned patients are another pool of organ donors who at present are probably underused by transplantation services.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Poisoned patients as potential organ donors: postal survey of transplant centres and intensive care units

2003

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“…There is no published case report of transfer of methanol intoxication from donor to recipient. The survival of the graft and also recipient of heart [1][2][3][4], lung [2,5,6], liver [1,2,4,5,7] and also kidney [1,4,7] from donors who die because of methanol does not differ in the short and long term from the transplants performed with organs from donors who die from other causes. Only the pancreas transplantation seems to be a contraindication [1,8].…”

Section: E48mentioning

confidence: 98%

Organ donation after Lethal Methanol Intoxication

Doede

Bröcker

Frühauf³

2014

Transpl Int

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“…Although organ donation after methanol intoxication was considered a serious option [21], family authorization, necessary because there was no donor declaration or written will available, could unfortunately not be obtained.…”

Section: Case Presentationmentioning

confidence: 99%

Accidental methanol ingestion: Case report

Epker

Bakker

2010

BMC Emerg Med

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BackgroundThe incidence of methanol (CH3OH) intoxication differs enormously from country to country. Methanol intoxication is extremely rare in the Dutch population. Even a low dose can already be potentially lethal. Patients are conventionally treated with hemodialysis. Therefore we'd like to present a report of a foreign sailor in Rotterdam who accidentally caused himself severe methanol intoxication, with a maximum measured concentration of 4.4 g/L.Case presentationThe patient presented with hemodynamic instability and severe metabolic acidosis with pH 6.69. The anion gap was 39 mmol/L and the osmol gap 73 mosmol/kg. Treatment with ethanol and continuous venovenous hemodiafiltration (CVVH-DF) was initiated. Despite the hemodynamic instability it is was possible to achieve rapid correction of pH and methanol concentration with CVVH-DF while maintaining a stable and therapeutic ethanol serum concentration. Despite hemodynamic and acid-base improvement, our patient developed massive cerebral edema leading to brain death. Permission for organ donation was unfortunately not ascertained.ConclusionsWe conclude that in a hemodynamic instable situation high methanol concentrations and methanol-induced derangements of homeostasis are safely and effectively treated with CVVH-DF and that severe cerebral edema is another possible cause of death rather than the classical bleeding in the putamen area.

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Fatal methanol poisoning and organ donation: experience with seven cases in a single center

Cited by 23 publications

References 4 publications

Poisoned patients as potential organ donors: postal survey of transplant centres and intensive care units

Poisoned patients as potential organ donors: postal survey of transplant centres and intensive care units

Organ donation after Lethal Methanol Intoxication

Accidental methanol ingestion: Case report

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