Fatal Myocardial Infarction in an Elderly Woman With Severe Ulcerative Colitis: What Is the Role of Steroids?

Baty, Vincent; Blain, Hubert; Jeandel, C; Canton, P.

doi:10.1111/j.1572-0241.1998.2000a.x

Cited by 16 publications

(11 citation statements)

References 3 publications

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“…This complication most commonly occurs in the lower extremities (1, 2); however, coronary embolization is very rare (1,3,4). We report a 50-year-old man with ulcerative colitis who had inferoposterior myocardial infarction.…”

Section: To the Editormentioning

confidence: 99%

“…Particularly, steroid therapy exacerbates diabetes, hypertension, congestive heart failure, and osteoporosis, or causes paradoxical depression. Baty et al (3) suggested that high-dose steroid therapy given in a very short time may cause cardiovascular complications. Our patient had received only 40 mg methylprednisolone prior to his sudden cardiac arrest.…”

Section: To the Editormentioning

confidence: 99%

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Acute myocardial infarction complicated by sudden cardiac arrest in a patient with ulcerative colitis

Senol¹,

Işler²,

Ozaydin³

et al. 2010

Turk J Gastroenterol

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Section: To the Editormentioning

confidence: 99%

Section: To the Editormentioning

confidence: 99%

Acute myocardial infarction complicated by sudden cardiac arrest in a patient with ulcerative colitis

Senol¹,

Işler²,

Ozaydin³

et al. 2010

Turk J Gastroenterol

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“…Commonly used medications to treat IBD disease “flares” also have been implicated in thrombotic‐ and atherosclerosis‐associated adverse events. High‐dose steroid use has been associated with an increased risk of thrombosis . Both patients presented had recently been started on high‐dose prednisone therapy because of an increase in symptoms related to IBD.…”

Section: Discussionmentioning

confidence: 99%

“…High-dose steroid use has been associated with an increased risk of thrombosis. 8 Both patients presented had recently been started on high-dose prednisone therapy because of an increase in symptoms related to IBD. They were also treated with azathioprine (patient LM) and infliximab (patient RS), both immunomodulatory therapies for IBD.…”

Section: Discussionmentioning

confidence: 99%

“…In reviewing the literature, five case reports document acute coronary syndrome believed related to IBD and its treatment. [8][9][10]16,17 A recent case report describes recurrent left ventricular thrombus in the setting of Crohn's disease with sequelae of arterial thromboembolism also suggesting that the presence of thrombus despite normal left ventricular function may not follow a benign course. 18 In conclusion, we present two unique cases demonstrating left ventricular thrombus formation in patients with preserved segmental left ventricular systolic function.…”

Section: Discussionmentioning

confidence: 99%

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Left Ventricular Thrombus in the Setting of Normal Left Ventricular Function in Patients with Crohn's Disease

et al. 2015

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Crohn's disease results in a hypercoagulable state increasing the risk of venous or arterial thromboembolism. Cardiac involvement has not been routinely identified. Two cases are presented to illustrate that patients with Crohn's disease may represent an exception to the rule that left ventricular apical thrombus should be associated with an underlying wall motion abnormality and reduction in left ventricular ejection fraction.

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Massive stent thrombosis during active ulcerative colitis: the tricky balance between manifest hemorrhagic and concealed thrombotic risk

et al. 2018

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Inflammatory bowel diseases have been recognized as predisposing factors to atherosclerosis and thrombotic events, involving both the venous and the arterial circulatory systems. We report the case of a 70-year-old man who presented with ST elevation myocardial infarction during the active phase of ulcerative colitis (UC). Because of the ongoing hematochezia, after successful revascularization of the culprit vessel, the patient was medicated with Clopidogrel, in place of one of the more powerful new oral P2Y inhibitors that currently represent the gold standard therapy. Few days later a second elective percutaneous coronary intervention (PCI) on a non-culprit vessel ensued in a life-threatening early massive stent thrombosis involving the left main. During and after emergency PCI antiplatelet therapy was upgraded to Abciximab and Ticagrelor; this therapy proved successful in handling the massive stent thrombosis in the absence of severe bleeding complications. This case is unique and paradigmatic of the complex management of patients with coexisting active UC and acute coronary syndromes; it demonstrates as in this setting the balance between hemorrhagic and ischemic risk is labile and tricky to assess.

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Fatal Myocardial Infarction in an Elderly Woman With Severe Ulcerative Colitis: What Is the Role of Steroids?

Cited by 16 publications

References 3 publications

Acute myocardial infarction complicated by sudden cardiac arrest in a patient with ulcerative colitis

Acute myocardial infarction complicated by sudden cardiac arrest in a patient with ulcerative colitis

Left Ventricular Thrombus in the Setting of Normal Left Ventricular Function in Patients with Crohn's Disease

Massive stent thrombosis during active ulcerative colitis: the tricky balance between manifest hemorrhagic and concealed thrombotic risk

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