Fatal Necrotizing Eosinophilic Myocarditis in a Patient With Relapsing Polychondritis

Bauer, Kristy; Zhong, Hua; Rapkiewicz, Amy; Rom, William N.; Steiger, David

doi:10.1378/chest.134.4_meetingabstracts.c1002

Cited by 2 publications

(3 citation statements)

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“…It is characterized by an extreme eosinophilic infiltration, marked edema, myocyte necrosis, and it often follows a more fulminant course. Such patients develop a severe heart failure within few days [13, 27].…”

Section: Reviewmentioning

confidence: 99%

“…Diuretics are sometimes needed to maintain optimum ventricular filling pressures [11]. Finally, for the treatment of fulminant EM, mechanical ventricular support is often used along with ionotropic agents to regulate and maintain proper myocardial contractility [27].…”

Section: Reviewmentioning

confidence: 99%

“…A pericardial effusion is seen in 75% of cases, occasionally causing tamponade. The mortality rate exceeds 50% and the median survival is only a few days [27]. The patient is usually healthy, experiences a rapid and acute progression to systolic failure, and hemodynamic compromise [11].…”

Section: Reviewmentioning

confidence: 99%

See 2 more Smart Citations

The Clinicopathological Profile of Eosinophilic Myocarditis

Sheikh¹,

Siddiqui²,

Uddin³

et al. 2018

Cureus

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Eosinophilic myocarditis (EM) is a rare form of myocarditis. As there is extreme diversity in its manifestations, the true incidence is difficult to assess and no proper epidemiological criteria are present. It generally presents with a wide array of clinical manifestations. Clinical presentation tends to differ in cases and not all the patients show the same signs and symptoms. The etiology of EM often remains obscure but potential causes have been identified which may include hypersensitivity to drugs, exposure to certain viruses and parasites, and hyper-eosinophilic syndromes. Endomyocardial biopsy is considered to be a gold standard for the diagnosis of EM. Echocardiography, cardiac magnetic resonance, and bio markers particularly serum eosinophilic cationic protein concentrations are also known to aid in diagnosis. EM may lead to progressive, irreversible, and fatal myocardial damage if prompt diagnosis is not made and therapy is not initiated. The current treatment regimens include corticosteroids, cytotoxic agents, and immunosuppressive therapy. However, a proper treatment criterion is yet to be established.

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Section: Reviewmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%