Fatal Nevirapine-Induced Toxic Epidermal Necrolysis in a HIV Infected Patient

Paik, Sabyasachi; Sen, Sukanta; Era, Nikhil; Saha, Bibhuti; Tripathi, Santanu Kumar

doi:10.7860/jcdr/2016/16360.7415

Cited by 7 publications

(5 citation statements)

References 14 publications

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“…6 However, the CD4 + count higher than 250 cells/mm 3 is associated with morbilliform rash caused by nevirapine. 19,20 In a 2011 study, it was mentioned that Nevirapine caused morbilliform rash in patients with the CD4 + count above 200 cells/mm 3 . 21 Additionally Kohlbrenner et.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Adverse Drug Reactions in Hospitalized HIV/AIDS Patients

Wibisono

Agusni

Hidayati

et al. 2021

BIKK

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Background: Cutaneous adverse drug reaction (CADR) is the most common manifestation of drug hypersensitivity in humanimmunodeficiency virus (HIV), which presented as maculopapular rash. The incidence of CADR is found to be more commonin untreated HIV patients, and the frequency is higher in severe immunodeficiency status. Early diagnosis and appropriatetreatment give better outcomes. Purpose: To evaluate the incidence and management of CADR in HIV and acquired immunedeficiency syndrome (AIDS) patients. Methods: A retrospective descriptive study of HIV/AIDS patients with CADR whowere hospitalized at Intermediate Care and Infectious Disease Centre Dr. Soetomo General Academic Hospital. Result: Therewere more CADR cases in 2017, accounted 2.35% of the total Intermediate Care and Infectious Disease Centre RSUD Dr.Soetomo General Academic Teaching Hospital ward patients. There were more male patients (62.5%), with the mostcommonly found at the age of 25-44 years (64.3%), and which mostly (89.3%) originated from Surabaya. The most commondiagnosis was morbiliform eruption (60.7%), main complaint was red spots all over the body (45%), all of which are obscureerythematous macules. The most common causes were Duviral + Neviral antiretroviral (46%) and the most common treatmentwas dexamethasone injection. Conclusion: The incidence of CADR increased in 2017. The most frequent manifestation wasmorbilliform eruption due to Duviral+Neviral as the first line ARV treatment. Skin management varies widely in form oftopical, oral, and intravenous injection drugs, mostly using steroid class, dexamethasone intravenous injection in particular.

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Section: Discussionmentioning

confidence: 99%

Cutaneous Adverse Drug Reactions in Hospitalized HIV/AIDS Patients

Wibisono

Agusni

Hidayati

et al. 2021

BIKK

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“…Protease inhibitors such as indinavir and ritonavir may cause pruritic maculopapular eruption, asteatotic dermatitis, lipodystrophy, pyogenic granuloma, acute porphyria, SJS, and DRESS [ 38 ].…”

Section: Metabolic Diseasesmentioning

confidence: 99%

A Comprehensive Review on HIV-Associated Dermatologic Manifestations: From Epidemiology to Clinical Management

Afshar

Goodarzi

Emadi

et al. 2023

International Journal of Microbiology

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Dermatological disorders are among the most prevalent manifestations of HIV infection/acquired immunodeficiency syndrome (AIDS). In this review, we aimed to characterize the various dermatologic presentations among HIV-infected patients with a detailed categorization of the mucocutaneous signs and symptoms, their etiopathogenic factors, and clinical management. In fact, cutaneous manifestations of HIV are quite various, ranging from AIDS-specific skin eruptions (xerosis, pruritic papular eruptions, eosinophilic folliculitis, and acne), opportunistic infections (herpes simplex, molluscum contagiosum, cutaneous leishmaniasis, bacillary angiomatosis, disseminated histoplasmosis, disseminated cryptococcosis, and zoster) to AIDS-related malignancies (Kaposi’s sarcoma, lymphoma, and nonmelanoma skin cancers) and antiretroviral therapy (ART)-associated drug eruptions. We tried to classify HIV-related cutaneous presentations which can help clinicians for a better understanding of the various specific and nonspecific features of AIDS-associated cutaneous manifestations and management of the condition.

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“…The aim of antiretroviral therapy (ART) is to suppress plasma HIV replication, restore and preserve immunologic function reducing HIV-associated morbidity, extending the duration and quality of survival, and preventing HIV transmission. 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 Most current recommendations indicate early ART initiation regardless of CD4+ T lymphocyte cell count.1–3…”

Section: Introductionmentioning

confidence: 99%