Fatal non-O1, non-O139 Vibrio cholerae septicaemia in a patient with chronic liver disease

Khan, Sadia; Kumar, Anil; Meparambu, Divya; Thomas, Sabu; Harichandran, Deepa; Karim, Shamsul

doi:10.1099/jmm.0.049296-0

Cited by 17 publications

(9 citation statements)

References 39 publications

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“…Though the isolates lacked virulence genes encoding for CT, Stn, Chx and structural genes of T3SS, the potential virulence genes such as hlyA, mshA , and rtxA were detected in all the isolates. Association of these genes in V. cholerae non-O1/non-O139 isolates has been reported in many findings ( Ottaviani et al, 2011 ; Dutta et al, 2013 ; Khan et al, 2013 ; Rajpara et al, 2013 ). Since V. cholerae non-O1/non-O139 is endemic in many regions, there should be a standby schema in place for routine screening this organism from septicemia/UTI cases.…”

Section: Discussionmentioning

confidence: 86%

Extraintestinal Infections Caused by Non-toxigenic Vibrio cholerae non-O1/non-O139

et al. 2016

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Vibrio cholerae is an aerobic, sucrose fermentative Gram-negative bacterium that generally prevails in the environment. Pathogenic V. cholerae is well-known as causative agent of acute diarrhea. Apart from enteric infections, V. cholerae may also cause other diseases. However, their role in causing extraintestinal infections is not fully known as it needs proper identification and evaluation. Four cases of extraintestinal infections due to V. cholerae non-O1/non-O139 have been investigated. The isolates were screened for phenotypic and genetic characteristics with reference to their major virulence genes. Serologically distinct isolates harbored rtx, msh, and hly but lacked enteric toxin encoding genes that are generally present in toxigenic V. cholerae. Timely detection of this organism can prevent fatalities in hospital settings. The underlying virulence potential of V. cholerae needs appropriate testing and intervention.

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Section: Discussionmentioning

confidence: 86%

Extraintestinal Infections Caused by Non-toxigenic Vibrio cholerae non-O1/non-O139

et al. 2016

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“…Presentations of non‐O1, non‐O139 V. cholerae infection predominately occur in summer months commonly manifesting as: gastroenteritis, cellulitis with bullous and haemorrhagic skin lesions, otitis externa/media, and bacteraemia. Chronic liver disease or malignancy is the primary underlying conditions reported, although bacteraemia has been infrequently reported in healthy hosts …”

Section: Case Series Of Non‐o1 Non‐o139 Vibrio Cholerae Bacteraemia mentioning

confidence: 99%

Non‐O1, non‐O139 Vibrio cholerae bacteraemia in an Australian population

Trubiano

Lee

Valcanis

et al. 2014

Internal Medicine Journal

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This retrospective case series identifies the largest cohort of non-O1, non-O139 Vibrio cholerae bacteraemia in an Australian population from 2000 to 2013. We examine the risk factors, epidemiology, clinical presentations and mortality of non-O1, non-O139 V. cholerae bacteraemia in Victoria and compare them with published cases in the literature. This case series highlights the pathogenic potential of non-O1, non-O139 V. cholerae and identifies possible associations with host (underlying chronic liver disease and malignancy) and environmental factors (contaminated water supply and raw seafood). Clinicians should be aware of the morbidity and mortality associated with invasive non-O1, non-O139 V. cholerae infections, particularly in immunocompromised patients.

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“…[ 15 ] In previous cases of cholera with acute peritonitis, all patients showed normal abdominal CT images and were usually diagnosed with spontaneous peritonitis. [ 16 , 17 ] However in this case, the V cholerae infection caused severe colon necrosis and septic shock, eventually leading to the death of the patient. This was a rare case of adult necrotic colitis caused by V cholerae infection, which is worthy of clinical attention.…”

Section: Discussionmentioning

confidence: 87%

Acute hemorrhagic necrotizing enterocolitis caused by non-O1/non-O139 Vibrio cholerae infection

Zhou²,

Cao³

2021

Medicine

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Rationale: Acute hemorrhagic necrotizing enterocolitis (AHNE) is a rapidly progressive and extremely dangerous disease. Here we report a rare case caused by Vibrio cholerae ( V cholerae ). Patient concerns: A 70-year-old man was admitted to our emergency department because of a sudden loss of consciousness. Diagnoses: On admission with severe toxic shock, the patient presented with elevated body temperature, decreased blood pressure, abdominal tenderness and rebound pain, predominantly on the right side. Computed tomography showed swelling and thickening of the right colon and peritoneal effusion. Necrosis was found in the hepatic flexure of the colon. On the basis of these results, the patient was diagnosed with AHNE. Interventions and outcomes: After fluid resuscitation, an exploratory laparotomy was performed immediately. The procedure was successful. Despite antibiotic therapy, the patient's clinical condition progressively deteriorated and he died of multi-organ failure on day 3 after admission. Lessons: AHNE is a rapidly progressive and extremely dangerous disease. Here we report a case of AHNE caused by non-O1/non-O139 V cholerae infection. The clinical features, phenotypic analyses and the presence of a panel of known virulence genes in the isolated strain are described. To the best of our knowledge, this is the first report of V cholerae causing severe AHNE, which is of profound pedagogical significance.

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Fatal non-O1, non-O139 Vibrio cholerae septicaemia in a patient with chronic liver disease

Cited by 17 publications

References 39 publications

Extraintestinal Infections Caused by Non-toxigenic Vibrio cholerae non-O1/non-O139

Extraintestinal Infections Caused by Non-toxigenic Vibrio cholerae non-O1/non-O139

Non‐O1, non‐O139 Vibrio cholerae bacteraemia in an Australian population

Acute hemorrhagic necrotizing enterocolitis caused by non-O1/non-O139 Vibrio cholerae infection

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