Fatal non-typeable Haemophilus influenzae sepsis complicated with acute respiratory distress syndrome: Case report and literature review

Wang, Shengru; Tseng, Min‐Jen; Lin, Wei-Jen; Teng, Ching-Shen; Wang, Chih‐Chien

doi:10.1080/00365540500262492

Cited by 4 publications

(3 citation statements)

References 10 publications

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“…Therefore, the pathogenesis of ARDS is most simply described as extensive acute injury of a specific kind of respiratory cell directly by various insults, including infectious agents and/or host immune responses, or secondarily by ischemic insults, such as pulmonary thromboembolism or near drowning. Infectious factors such as pneumonia with/without sepsis caused by a variety of pathogens, including pneumococci, influenza viruses, coronaviruses, and malaria can be the cause of ARDS [3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23]. Also, various non-infectious factors, such as aspiration of gastric contents, near drowning, blunt chest contusion, multiple injuries, inhalation burns, pancreatitis, and multiple blood transfusions are associated with ARDS [24,25,26,27,28,29,30,31,32,33,34,35].…”

Section: Introductionmentioning

confidence: 99%

Pneumonia, Acute Respiratory Distress Syndrome, and Early Immune-Modulator Therapy

Lee

2017

IJMS

125

113

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Acute respiratory distress syndrome (ARDS) is caused by infectious insults, such as pneumonia from various pathogens or related to other noninfectious events. Clinical and histopathologic characteristics are similar across severely affected patients, suggesting that a common mode of immune reaction may be involved in the immunopathogenesis of ARDS. There may be etiologic substances that have an affinity for respiratory cells and induce lung cell injury in cases of ARDS. These substances originate not only from pathogens, but also from injured host cells. At the molecular level, these substances have various sizes and biochemical characteristics, classifying them as protein substances and non-protein substances. Immune cells and immune proteins may recognize and act on these substances, including pathogenic proteins and peptides, depending upon the size and biochemical properties of the substances (this theory is known as the protein-homeostasis-system hypothesis). The severity or chronicity of ARDS depends on the amount of etiologic substances with corresponding immune reactions, the duration of the appearance of specific immune cells, or the repertoire of specific immune cells that control the substances. Therefore, treatment with early systemic immune modulators (corticosteroids and/or intravenous immunoglobulin) as soon as possible may reduce aberrant immune responses in the potential stage of ARDS.

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Section: Introductionmentioning

confidence: 99%

Pneumonia, Acute Respiratory Distress Syndrome, and Early Immune-Modulator Therapy

Lee

2017

IJMS

125

113

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“…H. influenzae type b is the most invasive of all serotypes and known as the main causer of meningitis, as well as the most relevant pathogen of the upper respiratory tract in children and in adults [6-9]. H. influenzae is responsible for 30 to 50% of all bacterial meningitis over the world and the second most common agent of pneumonia in children [10].…”

Section: Introductionmentioning

confidence: 99%

Haemophilus influenzae porine omp P2 gene transfer mediated by graphene oxide nanoparticles with effects on transformation process and virulence bacterial capacity

et al. 2014

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BackgroundH. influenzae is a natural competent bacterium that can uptake DNA from the environment and recombine into bacterial genome. The outbreaks of Brazilian purpuric fever, heavily polluted areas of a different H. influenzae biogroup - aegyptius - as well as gene transference between Neisseria meningitis make the transformation process an important evolutionary factor. This work studied the horizontal transference of the ompP2 gene from a multiresistant strain of H. influenzae 07 (NTHi), under the influence of graphene oxide nanoparticles in order to mimic an atmosphere rich in suspended particles and this way verify if the CFU transformants number was increased.Material and methodsIn this article the gene ompP2 was transformed into different strains of H. influenzae mediated or not by graphene oxide nanoparticles in suspension, followed by the adhesion tests in Hec-1B (human endometrium adenocarcinoma) and A549 (pulmonary epithelial carcinoma) cells lines. The transformation frequency and the adhesion capacity were determined in all the mutants to which the ompP2 gene was transferred and compared to their wild type strains.ResultsThe nanoparticles increased the transformation ratio of one particular strain isolated from a pneumonia case. The adhesion patterns to A549 and Hec1b cell lines of these mutated bacteria has their capacity increased when compared to the wild type.ConclusionsGraphene oxide nanoparticles aid the transformation process, helping to increase the number of CFUs, and the mutants generated with the ompP2 gene from a H. influenzae resistant strain not only present a chloramphenicol resistance but also have an increased adherence patterns in A549 and Hec1B cell lines.

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“…The NTHi is typically associated with moderate disease from the upper respiratory tract in children and pneumonia in adults with cystic fibrosis or chronicle obstructive disease [7]. The NTHi is a predominant bacterial agent of the prevalent pediatric disease otitis media (OM), and is also responsible for multiple diseases of the upper and lower respiratory tracts of both children and adults, although a commensal of the upper respiratory tracts of healthy persons, is an important cause of acute, recurrent, and persistent infections of the human respiratory tract [4].…”

Section: Introductionmentioning

confidence: 99%

Membrane Protein as Novel Targets for Vaccine Production in Haemophilus influenzae and Neisseria meningitid

Varela¹

2012

J Vaccines Vaccin

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Meningitis caused by bacterial infections is more likely to come with complications such as high mortality and morbidity levels. Among survivors, up to 20% have significant sequelae, including neurologic disability, amputation, and hearing loss [13]. The infections by meningococcal in the United States occur sporadically or in small clusters, and the most common Neisseira meningitidis serogroups involved are B, C, and Y. In some parts of the developing world, most notably across the center of Africa, serogroups A and, more recently, W135 cause severe epidemic disease [14]. The diagnosis of meningococcal disease presents challenges to the clinician because symptoms are similar to those of less serious illnesses, the symptoms have a sudden onset, and the disease may rapidly progress to permanent disability or death [15,16]. Neisseria meningitidis remains a major and insidious cause of death, even in industrialized countries

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Fatal non-typeable Haemophilus influenzae sepsis complicated with acute respiratory distress syndrome: Case report and literature review

Cited by 4 publications

References 10 publications

Pneumonia, Acute Respiratory Distress Syndrome, and Early Immune-Modulator Therapy

Pneumonia, Acute Respiratory Distress Syndrome, and Early Immune-Modulator Therapy

Haemophilus influenzae porine omp P2 gene transfer mediated by graphene oxide nanoparticles with effects on transformation process and virulence bacterial capacity

Membrane Protein as Novel Targets for Vaccine Production in Haemophilus influenzae and Neisseria meningitid

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