2020
DOI: 10.3389/fvets.2020.00018
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Fatal Ovarian Hemorrhage Associated With Anticoagulation Therapy in a Yucatan Mini-Pig Following Venous Stent Implantation

Abstract: Swine models are commonly utilized in endovascular research for development of intravascular interventions and medical device development. As part of a pilot study for a venous vascular stent device, a 5-year-old female Yucatan mini-pig underwent bilateral external iliac vein stent placement under general anesthesia. To reduce thrombotic complications by reduction of thrombus formation on wires, sheaths, and catheters, the pig was heparinized with a total of 300 IU/kg of heparin, establishing an activated clot… Show more

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Cited by 3 publications
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“…The components of circulatory and hemostatic systems are particularly vulnerable to environmental substances (xenobiotics) [ 1 , 2 , 3 , 4 ]. Vascular toxicity induced by chemical compounds is associated mainly with dysfunctions or damage to endothelial cells, changes in vascular permeability or dysregulation of the vascular redox state [ 5 ].…”
Section: Introductionmentioning
confidence: 99%
“…The components of circulatory and hemostatic systems are particularly vulnerable to environmental substances (xenobiotics) [ 1 , 2 , 3 , 4 ]. Vascular toxicity induced by chemical compounds is associated mainly with dysfunctions or damage to endothelial cells, changes in vascular permeability or dysregulation of the vascular redox state [ 5 ].…”
Section: Introductionmentioning
confidence: 99%