Fatal Pulmonary Infection with
            <i>Mycobacterium celatum</i>
            in an Apparently Immunocompetent Patient

Bux-Gewehr, Irene; Hagen, Hans P.; Rüsch-Gerdes, Sabine; Feurle, Gerhard E.

doi:10.1128/jcm.36.2.587-588.1998

Cited by 41 publications

(14 citation statements)

References 11 publications

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“…Mycobacterium celatum was first described in 1993 as a new mycobacterial species with a mycolic acid pattern closely related to that of Mycobacterium xenopi (Butler et al, 1993). The infections caused by this organism were reported to occur mostly in persons with suppressed cell-mediated immunity (Tortoli et al, 1995;Piersimoni et al, 1997;Gholizadeh et al, 1998;Fattorini et al, 2000), but some infections also occurred in the immunocompetent host (Bux-Gewehr et al, 1998;Fattorini et al, 2000;Piersimoni et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

The organization of two rRNA (rrn) operons of the slow-growing pathogenMycobacterium celatumprovides key insights into mycobacterial evolution

Stadthagen-Gomez¹,

Helguera-Repetto²,

Cerna-Cortés³

et al. 2008

FEMS Microbiology Letters

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The slow-growing Mycobacterium celatum is known to have two different 16S rRNA gene sequences. This study confirms the presence of two rrn operons and describes their organization. One operon (rrnA) was found to be located downstream from murA and the other (rrnB) was found downstream from tyrS. The promoter regions were sequenced, and also the intergenic transcribed spacer (ITS1 and ITS2) regions separating the 16S rRNA, 23S rRNA and 5S rRNA gene coding regions. Analysis of the RNA fraction revealed that rrnA is regulated by two (P1 and PCL1) promoters and rrnB is regulated by one (P1). These data show that the two rrn operons of M. celatum are organized in the same way as the two rrn operons of classical fast-growing mycobacteria. This information was incorporated into a phylogenetic analysis of the genus based on both 16S rRNA gene sequences and (where possible) the number of rrn operons per genome. The results suggest that the ancestral Mycobacterium possessed two (rrnA and rrnB) operons per genome and that subsequently, on two separate occasions, an operon (rrnB) was lost, leading to two clusters of species having a single operon (rrnA); one cluster includes the classical pathogens and the other includes Mycobacterium abscessus and Mycobacterium chelonae.

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Section: Introductionmentioning

confidence: 99%

The organization of two rRNA (rrn) operons of the slow-growing pathogenMycobacterium celatumprovides key insights into mycobacterial evolution

Stadthagen-Gomez¹,

Helguera-Repetto²,

Cerna-Cortés³

et al. 2008

FEMS Microbiology Letters

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“…Susceptibility testing of isolated M. celatum strain to second-line antibiotics failed due to stopped growth of the bacteria after the passage on antibiotic-free, control medium, which should obligatory accompany the culture on antibiotic-containing media. The successful treatment with clarithromycin and ciprofloxacine was described by others [7,9,10] , while the resistance to isonizyd, rifampicin and ethambutol was documented [7,8] . By Butler et al , who first extensively described M. celatum: "Strains are completely or partially resistant to most antituberculosis drugs tested but are susceptible to a high concentration of streptomycin (10.0 µg/ml) and ciprofloxacin" [4] .…”

Section: The Protocol Of Microbiological Diagnosis In Ourmentioning

confidence: 94%

“…Most cases were described in AIDS patients [5][6][7] . However, there are some reports on M. celatum in immunocompetent patients with various response to treatment [8][9][10] .…”

Section: Introductionmentioning

confidence: 99%

Mycobacterium celatum infection: Successful treatment with ciprofloxacin and clarithromycin

Kulawik

Safianowska²,

Walkiewicz³

et al. 2014

CRIM

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Mycobacterium celatum is nontuberculous mycobacterium which is rarely pathogenic in human. We describe the case of M. celatum infection in immunocompetent patient. Caucasian 64-years old female patient was referred to the outpatient service because of pulmonary hemorrhage, cough and fever up to 39oC. She reported previous pulmonary tuberculosis (TB) 3 years ago. At presentation the physical examination was unremarkable. Chest computed tomographic scan showed multifocal bronchiectases and upper lobes consolidations suggestive. Empiric antibiotic therapy with amoxicillin was undertaken. At the same time the consecutive sputum samples were immediately analyzed. Smears of six from eight sputum specimens were positive for acid-fast bacilli by Ziehl-Neelsen staining. Culture from each specimen produced slow-growing mycobacterium, identified as M. celatum by mycolic acid analysis with high performance liquid chromatography. The treatment with clarithromycin and ciprofloxacin was continued for 18 months with clinical improvement. Conclusion- we present the accuracy of microbiological diagnosis of M. celatum in patient with normal immune status, which allowed successful treatment. M. celatum infection was reported in HIV infected patients or with the history of pulmonary TB prior to mycobacterial infection. Also in our patient the TB in anamnesis may indicate “hidden immunodeficiency”.

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“…The first report of a localized lymphadenitis in a previously healthy boy, came in 1994 [6] and a second in a 22-month-old infant was in 2004 [7]. The first case of pulmonary infection in an immunocompetent individual was detected post mortem in a patient treated for suspected tuberculosis [8]. The second case was described from Maastricht in 1999, where a 61-year-old male was presented with a history of three years of weight loss, cough, malaise and had a cavity in the right upper lobe.…”

Section: Introductionmentioning

confidence: 99%

Fatal Pulmonary Mycobacterium Celatum Infection in an Immunocompetent Patient. An Eight-Year Follow-Up of the First Case, a Review of the Literature and a Report of Beta-2 Microglobulin as a Potential Indicator of Disease Severity

Rustscheff¹,

Darelid²

2013

AID

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Setting: Swedish county hospital. Objective: Pulmonary M. celatum infection has been previously described only twice in an immunocompetent individual with no pre-existing chest disease. We describe the first Swedish case report of unusual drug-related complications and review the literature. Discussion: Atypical mycobacteriosis is often difficult to treat. We describe a fatal case of m celatum pneumonia in a previously healthy patient, unusual side effects encountered during her treatment and also the report of the utility of beta-2-microglobulin as a way to measure disease activity in mycobacterial infections. Conclusions: M. celatum may cause fatal pneumonia in previously healthy individuals. Treating the disease may be fraught with difficulty and there is a risk for very severe side effects, all of which must be weighed before taking the decision to treat this disease.

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Fatal Pulmonary Infection with Mycobacterium celatum in an Apparently Immunocompetent Patient

Cited by 41 publications

References 11 publications

The organization of two rRNA (rrn) operons of the slow-growing pathogenMycobacterium celatumprovides key insights into mycobacterial evolution

The organization of two rRNA (rrn) operons of the slow-growing pathogenMycobacterium celatumprovides key insights into mycobacterial evolution

Mycobacterium celatum infection: Successful treatment with ciprofloxacin and clarithromycin

Fatal Pulmonary Mycobacterium Celatum Infection in an Immunocompetent Patient. An Eight-Year Follow-Up of the First Case, a Review of the Literature and a Report of Beta-2 Microglobulin as a Potential Indicator of Disease Severity

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