2005
DOI: 10.1128/jcm.43.7.3551-3554.2005
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Fatal Reactivation of Postnatal Cytomegalovirus Infection with Rapid Emergence of Ganciclovir Resistance in an Infant after Allogeneic Stem Cell Transplantation

Abstract: Human cytomegalovirus (HCMV) can cause serious problems after hematopoietic stem cell transplantation. The death of a pediatric transplant recipient after reactivation of a postnatal HCMV infection with bilateral retinitis and pneumonitis is described. Sequencing of the HCMV UL97 region revealed a compartment-specific mutation (H520Q) in urine conferring ganciclovir resistance. CASE REPORTA 3-month-old infant had been diagnosed with juvenile myelomonocytic leukemia (JMML), a rare myeloproliferative disorder of… Show more

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Cited by 8 publications
(8 citation statements)
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“…In addition, H520Q was also detected in plasma as a minority of 10%. This could not be confirmed by conventional sequencing in the present study, and only a doubtful mutant peak had been seen in that sample in the previous study (20). Importantly, we additionally detected A594V (20%) and C603W (10%) mutations in the urine sample and C607Y mutants in plasma (13%) and urine (24%).…”
Section: Vol 54 2010contrasting
confidence: 84%
See 1 more Smart Citation
“…In addition, H520Q was also detected in plasma as a minority of 10%. This could not be confirmed by conventional sequencing in the present study, and only a doubtful mutant peak had been seen in that sample in the previous study (20). Importantly, we additionally detected A594V (20%) and C603W (10%) mutations in the urine sample and C607Y mutants in plasma (13%) and urine (24%).…”
Section: Vol 54 2010contrasting
confidence: 84%
“…Conventional sequencing of the HCMV UL97 region had revealed a compartment-specific H520Q mutation in urine that conferred GCV resistance (20). Limited amounts of DNA from some patient samples were still available and could be retrospectively analyzed with PSQ assays 2 and 3.…”
Section: Vol 54 2010mentioning
confidence: 99%
“…In allo‐HSCT patients, GCV resistance is usually driven by mutations in UL97 , with M460I/V, C592G, A591V, A594T/V, L595F/S, and C603W resistance mutations as the most prevalent . Other less common mutations have also been identified , and furthermore, del601‐603 and E655K mutations have only been reported in HSCT recipients (Table ).…”
Section: Human Cytomegalovirus Drug Resistancementioning
confidence: 99%
“…[3][4][5][6][7][8] Opportunistic infections due to the immunosuppressed status in the first months after HSCT may affect the eye; however, to our knowledge, no systematic prospective studies have been performed to investigate the exact risk of ocular disease in the pediatric HSCT population. 1,3,[9][10][11][12][13][14][15][16][17] Because of improving clinical control of these infections and lower mortality, it is essential to have insights into the risk of ocular involvement after HSCT in this vulnerable population because young and severely ill children are unaware of their ocular problems.…”
mentioning
confidence: 99%