Fatal transmission of contagious caprine pleuropneumonia to an Arabian oryx (Oryx leucoryx)

Chaber, Anne‐Lise; Lignereux, Louis; Qassimi, M Al; Saegerman, Claude; Manso-Silván, Lucía; Dupuy, Virginie; Thiaucourt, François

doi:10.1016/j.vetmic.2014.07.003

Cited by 22 publications

(12 citation statements)

References 10 publications

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“…Transmission of M. capricolum subsp. capripneumoniae to wild ungulates such as Arabian Oryx and Tibetan antelope has also been reported [4, 5]. Despite the fact that CCPP is on the list of diseases notifiable to the World Organization for Animal Health (OIE), only a few countries reported outbreaks between 2014 and 2018 (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Reproduction of contagious caprine pleuropneumonia reveals the ability of convalescent sera to reduce hydrogen peroxide production in vitro

Liljander

Sacchini

Stoffel

et al. 2019

Vet Res

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Contagious caprine pleuropneumonia (CCPP), caused by Mycoplasma capricolum subsp. capripneumoniae is a severe disease widespread in Africa and Asia. Limited knowledge is available on the pathogenesis of this organism, mainly due to the lack of a robust in vivo challenge model and the means to do site-directed mutagenesis. This work describes the establishment of a novel caprine challenge model for CCPP that resulted in 100% morbidity using a combination of repeated intranasal spray infection followed by a single transtracheal infection employing the recent Kenyan outbreak strain ILRI181. Diseased animals displayed CCPP-related pathology and the bacteria could subsequently be isolated from pleural exudates and lung tissues in concentrations of up to 109 bacteria per mL as well as in the trachea using immunohistochemistry. Reannotation of the genome sequence of ILRI181 and F38T revealed the existence of genes encoding the complete glycerol uptake and metabolic pathways involved in hydrogen peroxide (H2O2) production in the phylogenetically related pathogen M. mycoides subsp. mycoides. Furthermore, the expression of L-α-glycerophosphate oxidase (GlpO) in vivo was confirmed. In addition, the function of the glycerol metabolism was verified by measurement of production of H2O2 in medium containing physiological serum concentrations of glycerol. Peroxide production could be inhibited with serum from convalescent animals. These results will pave the way for a better understanding of host–pathogen interactions during CCPP and subsequent vaccine development.Electronic supplementary materialThe online version of this article (10.1186/s13567-019-0628-0) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Reproduction of contagious caprine pleuropneumonia reveals the ability of convalescent sera to reduce hydrogen peroxide production in vitro

Liljander

Sacchini

Stoffel

et al. 2019

Vet Res

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“…However, WGS-based genotyping is not available to diagnostic laboratories, particularly in the regions where CCPP is prevalent, and MLSA may still be a valuable alternative, especially when isolation cannot be achieved. Only a few Mccp isolates and WGS have been made available since the MLSA work of 2011 and subsequent reports relating to Mccp strains from wildlife in the United Arab Emirates [ 7 , 8 ], but MLSA has been conducted following investigations of CCPP outbreaks in Tibetan wild ungulates first identified in 2012 [ 9 ] and, more recently, in Pakistani goats in 2019 [ 10 ]. The objective of our study was thus to explore the diversity of Mccp strains in Asia, by analysing new MLSA data from Pakistan and China, including strains originating from wildlife.…”

Section: Introduction Methods and Resultsmentioning

confidence: 99%

Multi-locus sequence analysis reveals great genetic diversity among Mycoplasma capricolum subsp. capripneumoniae strains in Asia

Akhtar

Boissière

Hao

et al. 2022

Vet Res

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Multi-Locus Sequence Analysis (MLSA) of Mycoplasma capricolum subsp. capripneumoniae (Mccp) strains from Asia revealed unforeseen diversity and a central position for genotyping groups representing strains from Central/East Asia, suggesting a possible origin of contagious caprine pleuropneumonia in this continent. A better assessment of the emergence, diversity and distribution of Mccp in Asia and Africa calls for renewed efforts to dramatically enlarge the sample of strains. Availability and affordability in the field, added to superior typeability (directly from poor samples) and high stability, discriminatory power and concordance with epidemiological and phylogenetic analyses, make MLSA an excellent tool for such investigations.

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“…Most of the sheep and goats are bred in Abu Dhabi, respectively, 85% and 65% of the country flock (United Arab Emirates National Bureau of Statistics, ), where herd Brucella seroprevalence is of 55.1% (Mohammed et al., ). Some diseases are known to be enzootic and/or epizootic in the country such as contagious caprine pleuropneumonia (Chaber et al., ), foot‐and‐mouth disease (Lignereux and Al Kharusi, ), Q fever (Chaber et al., ), lumpy skin disease (Tuppurainen and Oura, ), bovine tuberculosis (Wernery et al., ). Other diseases seem to be directly related to international animal trade (livestock or wildlife), such as Crimean–Congo haemorrhagic fever (Rodriguez et al., ) and Rift Valley fever (Boshra et al.…”

Section: Discussionmentioning

confidence: 99%

Biosecurity Measures Applied in the United Arab Emirates - a Comparative Study Between Livestock and Wildlife Sectors

Chaber

Saegerman

2016

Transbound Emerg Dis

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In 2013, the livestock population in the UAE exceeded 4.3 million heads with sheep and goats accounting for 90% of this. The overall number of captive wild ungulates (gazelle types) is difficult to assess as there is no registration system in place or enforced in the UAE with regard to the possession of wildlife. Those animal collections, mainly owned by high-ranking families, are therefore not registered and kept far from public viewing. Nonetheless, some collections are housing more than 30 000 ungulates in one location. The primary objective of this study was to describe the biosecurity measures currently applied in UAE ungulate facilities for different wildlife and livestock sectors. A secondary objective was to use the output from this biosecurity survey to investigate which sector could be categorized into risk groups for disease introduction and spread. Between October 2014 and May 2015, biosecurity questionnaire data were collected in the Emirates of Abu Dhabi, Dubai, Ras Al Khaimah, Fujeirah, Ajman, Umm al Quwain and Sharjah from 14 wildlife collections, 30 livestock farms and 15 mixed (wildlife and livestock farms). These investigations through questionnaires allowed us to quantify and assess statistically biosecurity practices and levels for both livestock and wildlife sectors. In both sectors, biosecurity measures could be improved and only a few facilities had high biosecurity scores. The group of small unregistered farms (Ezba) represented the highest risk of disease transmission to other animals due to their lack of biosecurity awareness.

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Fatal transmission of contagious caprine pleuropneumonia to an Arabian oryx (Oryx leucoryx)

Cited by 22 publications

References 10 publications

Reproduction of contagious caprine pleuropneumonia reveals the ability of convalescent sera to reduce hydrogen peroxide production in vitro

Reproduction of contagious caprine pleuropneumonia reveals the ability of convalescent sera to reduce hydrogen peroxide production in vitro

Multi-locus sequence analysis reveals great genetic diversity among Mycoplasma capricolum subsp. capripneumoniae strains in Asia

Biosecurity Measures Applied in the United Arab Emirates - a Comparative Study Between Livestock and Wildlife Sectors

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