Fatal tumor lysis syndrome after irinotecan/5-FU/folinic acid/bevacizumab-containing therapy in a patient heavily pretreated for metastatic colon cancer

Abstract

(2008) Fatal tumor lysis syndrome after irinotecan/5-FU/folinic acid/ bevacizumab-containing therapy in a patient heavily pretreated for metastatic colon cancer, Acta Oncologica, 47:1, 155-156,

Tumor Lysis Syndrome in Solid Tumors: An up to Date Review of the Literature

“…Some patients had baseline elevation of LDH, 85,87-89 potassium, 85 phosphorus, 85 uric acid, 85,89 and creatinine. 89 It is important to note that these baseline laboratory abnormalities were not high enough to meet the criteria for laboratory TLS (Table 1).…”

“…89 It is important to note that these baseline laboratory abnormalities were not high enough to meet the criteria for laboratory TLS (Table 1). It is also important to note that some reports did not provide any baseline laboratory values and some provided only a few.…”

An Unusual Presentation of Tumor Lysis Syndrome in a Patient with Advanced Gastric Adenocarcinoma: Case Report and Literature Review

“…According to the literature review, there have been 100 reported cases of TLS in patients with solid tumors from the first report in 1977 to 2011 (Table 1) (Figure 2), including small cell carcinomas [9, 20–30], squamous cell carcinomas [10, 11], adenocarcinomas of the lung [12, 31–33], mixed small cell and nonsmall cell lung carcinoma [34], gastrointestinal carcinomas [13–15, 35–42], hepatoblastomas [43, 44], hepatocellular carcinomas [15, 45–53], renal carcinomas [54–56], transitional cell carcinoma [57], prostate carcinomas [58–61], breast carcinomas [16, 30, 62–68], ovarian carcinomas [69, 70], endometrial carcinoma [71], vulva carcinomas [72, 73], thymomas [74, 75], melanomas [76–82], gestational trophoblastic neoplasia [83], germ cell tumors [17, 18, 64, 84, 85], neuroblastomas [86, 87], medulloblastomas [88, 89], and sarcomas [19, 90–93]. Most cases regarded as TLS in solid tumors were chemotherapy-induced, even though various other causes were pointed out for TLS in solid tumors as well [3] (Table 1) (Figure 1).…”

Tumor Lysis Syndrome in a Patient with Metastatic Colon Cancer after Treatment with 5-Fluorouracil/Leucovorin and Oxaliplatin: Case Report and Literature Review

“…The first such patient, who had a widespread adenocarcinoma of gastrointestinal origin with renal failure, was reported in 1977 [4], and an additional 74 patients with solid tumors who developed TLS were reported between 1977 and 2011. These solid tumors included breast cancer, small cell lung cancer, germ cell tumor, melanoma, Merkel cell carcinoma, head and neck cancer, non-small cell lung cancer, ovarian cancer, vulva cancer, prostate cancer, hepatocellular carcinoma, colorectal cancer, gastric cancer, sarcoma, neuroblastoma, medulloblastoma, hepatoblastoma, gestational trophoblastic neoplasia, renal cell carcinoma, transitional cell carcinoma, and thymoma [1,5,6,7,8,9,10,11,12,13]. …”

“…Although development of TLS has been reported in several patients with colorectal cancer after treatment with irinotecan [10,11,12,13], none of these patients was receiving FOLFOX chemotherapy. To the best of our knowledge, the current case constitutes the sixth reported case of a patient with colorectal cancer who developed TLS, and is the first report in a patient undergoing FOLFOX chemotherapy (Table 1).…”