Fatao coxsackievirus B infection in early infancy characterized by fulminant hepatitis

Wang, S.-M.; Liu, C.-C.; Yu, Yi; Yang, Hsio Bai; Lin, Chou-Ching K.; Wang, J.-R.

doi:10.1016/s0163-4453(98)92076-x

Cited by 48 publications

(36 citation statements)

References 11 publications

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“…The present study, with enrollment of more patients, indicated a stronger association between peak serum AST level and clinical outcome and this association was evident as early as within the first 3 days of illness. In this study, an serum AST level higher than 1000 IU/L, particularly >2000 IU/L, was associated with a higher case-fatality rate, which was consistent with previous studies [14,[19][20][21][22][23]. Since the clinical condition of these patients can deteriorate rapidly, we suggest that a frequent blood sampling for evaluation of serum AST level in early stage of the illness be mandatory for neonates with suspicion of severe enterovirus infections.…”

Section: Discussionsupporting

confidence: 91%

“…In addition, the optimal dosage of IVIG therapy for severe neonatal enterovirus infections is not clear. In the current study the total dosage of IVIG therapy was relatively higher than what had been reported in the literature [14,23,24]. However, no significant difference was evident between the total dosages used for the survivors and the deceased.…”

Section: Discussioncontrasting

confidence: 70%

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Effect of intravenous immunoglobulin for neonates with severe enteroviral infections with emphasis on the timing of administration

Yen

Huang

Chen

et al. 2015

Journal of Clinical Virology

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Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 70%

Effect of intravenous immunoglobulin for neonates with severe enteroviral infections with emphasis on the timing of administration

Yen

Huang

Chen

et al. 2015

Journal of Clinical Virology

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“…Two important enteroviruses, enterovirus 71 (EV71) and coxsackievirus B, are the dominant pathogens of these outbreaks [1,2]. The largest outbreak of hand-foot-and-mouth disease (HFMD) due to EV71 infection occurred in 1998, including 129,106 case reports, 405 children with brainstem encephalitis (BE), and 78 deaths [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Reemerging of enterovirus 71 in Taiwan: the age impact on disease severity

Wang

Lin³

et al. 2011

Eur J Clin Microbiol Infect Dis

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Enterovirus 71 (EV71) infection commonly strike children under the age of 3 years, with an occasionally unfavorable outcome in children. This study was designed to explore the relationship between age and the severity of complications, which may associate with antibody-dependent enhancement (ADE) in EV71. All EV71-infected patients during the outbreak of 2008 were recruited. In total, 134 patients were enrolled and categorized into two age groups, 0-12 months (n = 18) and >12 months (n = 116). Pulmonary edema/hemorrhage more commonly occur in patients younger than 12 months. No difference in the occurrence of herpangina/hand-foot-and-mouth disease (HFMD), uncomplicated brainstem encephalitis (BE), or autonomic nervous system (ANS) dysregulation was noted between the two age groups. Patients with pulmonary edema/hemorrhage (11.9 ± 14.7 months) were younger than patients with herpangina/HFMD (35.8 ± 26.4 months) or ANS dysregulation (33.9 ± 20.9 months). Our findings are in agreement with the data regarding the outbreak in Taiwan, in which a decrease in age corresponded to an increase in disease severity with regard to central nervous system complications. A reduction of maternal antibodies to the subneutralizing level within 1 year of age may be associated with the ADE of the infection. This study could provide possible clinical significance with regard to ADE phenomena in young infants infected by EV71.

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“…EV, especially CVB, cause a wide spectrum of human diseases. CVB1 has been found in patients with fulminant hepatitis, insulin-dependent diabetes mellitus (IDDM), pleurodynia [1][2][3], and CVB2 has been found in patients with IDDM, myocarditis, aseptic meningitis, and hand, foot and Moon/Joo/Hwang/Ye/Jun/Lee/Kim/Lee/ Lee/Kim mouth disease [2,[4][5][6]. CVB3 is the most common cause of human viral myocarditis and the subsequent development of dilated cardiomyopathy [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Distribution of Viral RNA in Mouse Tissues during Acute Phase of Coxsackievirus B5 Infection

Moon¹,

Joo²,

Hwang³

et al. 2005

Intervirology

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Objective: To investigate histopathological changes and distribution of coxsackievirus B5 (CVB5) RNA in mouse heart, liver, and pancreas during the acute phase of infection. Methods: C3H/HeJ male mice, aged 3–4 weeks, were inoculated intraperitoneally with 5 × 10⁵ plaque-forming units of CVB5 and sacrificed at 1, 2, 3, 4, 7 and 10 days postinfection (p.i.). Inflammation of the heart, liver, and pancreatic tissue sections was evaluated by hematoxylin and eosin staining, and virus was detected using antibody to viral coat protein VP1. A quantitative real-time RT-PCR method, using primers and probe targeted to the highly conserved sequences in the 5’-untranslated region of the virus, was used to evaluate the kinetics of CVB5 RNA during the development of myocarditis or pancreatitis. Results: Marginal inflammatory changes were observed in the heart tissues although viral RNA was constantly present between 1 and 10 days p.i., peaking at 4 days p.i. The pancreatic tissues displayed massive lymphocyte infiltration and loss of acinar cells at day 4 p.i. and viral RNA was detected between 1 and 10 days p.i., peaking at 2–3 days p.i. In the liver, viral RNA was detected between 1 and 7 days. No mortality was observed. Conclusions: CVB5 induced acute pancreatitis without subsequent development of myocarditis. Clearance of CVB5 RNA from the pancreas and heart was slower than clearance from the liver. Our real-time RT-PCR method, which is more sensitive than conventional plaque assay, may provide valuable insight into viral RNA kinetics during CVB5 infection.

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Fatao coxsackievirus B infection in early infancy characterized by fulminant hepatitis

Cited by 48 publications

References 11 publications

Effect of intravenous immunoglobulin for neonates with severe enteroviral infections with emphasis on the timing of administration

Effect of intravenous immunoglobulin for neonates with severe enteroviral infections with emphasis on the timing of administration

Reemerging of enterovirus 71 in Taiwan: the age impact on disease severity

Distribution of Viral RNA in Mouse Tissues during Acute Phase of Coxsackievirus B5 Infection

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