Fate of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in a model aquatic environment

Ward, Claudia T.; Matsumura, Fumio

doi:10.1007/bf02332062

Cited by 59 publications

(23 citation statements)

References 11 publications

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“…Only transport due to soil erosion would be likely. Ward and Matsumura (1978) confirmed the conclusions of Helling and others (1973) in a study employing anaerobic sediment-water microcosms dosed with radio-labeled TCDD. They found that typically 93 to 96 percent of the recovered radioactivity was from the sediment and speculated that much of the remaining TCDD was associated with dissolved organic matter.…”

Section: Environmental Fatesupporting

confidence: 79%

“…In surface-water systems, the rapid sorption of TCDD to sediments greatly reduces the amount of light reaching the TCDD molecules, thereby reducing the rate of photodecomposition. This is confirmed by an experiment by Ward and Matsumura (1978), who compared the degradation of TCDD in sedimentwater microcosms incubated in the dark with identically prepared microcosms incubated in the light. After 39 d, the average recovery of TCDD from the "dark" microcosms was 93.29 percent and the average recovery of TCDD from the "light" microcosm was 89.45 percent, indicating the lack of a significant photolytic influence.…”

Section: Environmental Fatesupporting

confidence: 57%

“…In a laboratory sediment-water system incubated under anaerobic conditions, the half-life of TCDD was found to be approximately 600 d (Ward and Matsumura, 1978). Similarly, Helling and others (1973) reported that TCDD applied to moist soils exhibited half-lives of approximately 1 yr in the laboratory.…”

Section: Environmental Fatementioning

confidence: 95%

See 2 more Smart Citations

Manmade organic compounds in the surface waters of the United States; a review of current understanding

Smith¹,

Witkowski²,

Fusillo³

1988

Circular

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Section: Environmental Fatesupporting

confidence: 79%

Section: Environmental Fatesupporting

confidence: 57%

See 1 more Smart Citation

Manmade organic compounds in the surface waters of the United States; a review of current understanding

Smith¹,

Witkowski²,

Fusillo³

1988

Circular

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“…Earlier biodegradation studies using laboratory soil systems and model ecosystems showed that the concentration of 2,3,7,8-TCDD incorporated into these systems was decreased to some extent due in part to microbial activity 101,120,151,192) . Probably, indigenous microorganisms in polluted soils have the ability to degrade dioxins more or less 12) .…”

Section: Bioremediation Of Polluted Materials and Model Ecosystemsmentioning

confidence: 99%

“…As microorganisms play important roles in the degradation and mineralization of xenobiotic and aromatic compounds in natural environments, biological methods using particular microorganisms or microbial consortia capable of dioxin transformation and degradation have greater appeal than physicochemical ones in their potential application for environmental remediation. Studies on microbial degradation of dioxins started appearing in 1970's 101,120,192) . Since then, large numbers of microorganisms capable of degrading dioxins and related aromatics have been isolated and characterized.…”

mentioning

confidence: 99%

Biodiversity of Dioxin-Degrading Microorganisms and Potential Utilization in Bioremediation.

Hiraishi

2003

Microb. Environ.

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Dioxins are a group of chloroaromatic compounds known to be toxic and carcinogenic, and persistent environmental pollutants. How to remedy dioxin-polluted environments is one of the most challenging problems in environmental technology. From ecological and economical viewpoints, biological methods using particular microorganisms and microbial consortia capable of dioxin transformation and degradation have greater appeal than physicochemical methods in their application for environmental remediation. Large numbers of microorganisms capable of degrading dioxins and dioxin-like compounds have been isolated and characterized. Information about the biodiversity, ecophysiology and molecular biology of dioxin-degrading microorganisms has accumulated particularly during the past decade. There are three major modes of microbial degradation and transformation of dioxins; that is, oxidative degradation by aerobic bacteria containing aromatic hydrocarbon dioxygenases, reductive dechlorination by anaerobic microorganisms and fungal oxidation with cytochrome P-450, lignin peroxidases and laccases. This article overviews the current knowledge of microbial degradation and transformation of dioxins as well as the biodiversity of microorganisms involved. Strategies directed towards the bioremediation of dioxin-polluted environments are discussed.

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Possibility of application of cytochrome P450 to bioremediation of dioxins

Sakaki

Yamamoto

Ikushiro

2013

Biotech and App Biochem

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Dioxins, including polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans, and coplanar polychlorinated biphenyls, are known to be metabolized by enzymes such as cytochrome (CYP) P450, angular dioxygenase, lignin peroxidase, and dehalogenase. It is noted that all of these enzymes have metal ions in their active centers, and the enzyme systems except for peroxidase each have a distinct electron transport chain. Among these enzyme systems, we have focused on cytochrome P450-dependent metabolism of dioxins from the viewpoint of practical use for bioremediation. Mammalian and fungal cytochromes P450 showed remarkable activity toward low-chlorinated PCDDs. In particular, mammalian cytochromes P450 belonging to the CYP1 family showed high activity. Rat CYP1A1 showed high activity toward 2,3,7-trichloro-dibenzo-p-dioxin but no detectable activity for 2,3,7,8-tetrachloro-dibenzo-p-dioxin (2,3,7,8-TCDD). On the basis of these results, we assumed that enlarging the space of the substrate-binding pocket of rat CYP1A1 might generate TCDD-metabolizing enzyme. Large-sized amino acids located at putative substrate-recognition sites and F-G loop were substituted for alanine by site-directed mutagenesis. Finally, we successfully generated 2,3,7,8-TCDD-metabolizing enzyme by site-directed mutagenesis of rat CYP1A1. We hope that recombinant microorganisms harboring genetically engineered cytochrome P450 will be used for bioremediation of soil contaminated with PCDDs, polychlorinated dibenzofurans, and coplanar polychlorinated biphenyls in the future.

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Fate of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in a model aquatic environment

Cited by 59 publications

References 11 publications

Manmade organic compounds in the surface waters of the United States; a review of current understanding

Manmade organic compounds in the surface waters of the United States; a review of current understanding

Biodiversity of Dioxin-Degrading Microorganisms and Potential Utilization in Bioremediation.

Possibility of application of cytochrome P450 to bioremediation of dioxins

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