Fate of cancerostatic platinum compounds in biological wastewater treatment of hospital effluents

Lenz, Katharina; Koellensperger, Gunda; Weißenbacher, N.; Mahnik, Susanne N.; Fuerhacker, Maria

doi:10.1016/j.chemosphere.2007.05.062

Cited by 113 publications

(61 citation statements)

References 12 publications

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“…It has been observed that the microbial activity is helpful to generate an in situ reducing environment for metal ion reduction and the subsequent catalytic reactions as well [60][61][62]. Lenz et al [63] showed the important role of metal species in reduction potential and bacterial uptake efficiency. For example, bio-reduction of various palladium species has shown the influence of reduction potential for obtaining the reduced Pd 0 nanoparticles using microbes (viz.…”

Section: Au + 8cn + O + 2h O → 4au Cn + 4ohmentioning

confidence: 99%

Bio-Reclamation of Strategic and Energy Critical Metals from Secondary Resources

Ilyas

Kim

Lee

et al. 2017

Metals

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Abstract:Metals with an average crustal abundance of <0.01 ppm, which are high in supply shortage due to soaring demand, can, under the excessive environmental risk and <1% recycling rate of their production, be termed as 'critical' in a limited geo-boundary. A global trend to the green energy and low carbon technologies with geopolitical scenario is challenging for the sustainable reclamation of these metals from secondary resources. Among the available processes, bio-reclamation can be a sustainable technique for extracting and concentrating these metals. Therefore, in the present paper, the potential reclamation of critical metals (including rare earth elements, precious metals, and a common nuclear fuel element, uranium) via their interaction with microbe/s has been reviewed.

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Section: Au + 8cn + O + 2h O → 4au Cn + 4ohmentioning

confidence: 99%

Bio-Reclamation of Strategic and Energy Critical Metals from Secondary Resources

Ilyas

Kim

Lee

et al. 2017

Metals

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“…5,7,8 Therefore, more effective technologies such as ozonation should be employed. The ozonation of cisplatin at pH 9 in non-buffered aqueous solutions was recently reported by Hernández et al.…”

Section: Cisplatin Cis-diamminedichloroplatinum(ii)mentioning

confidence: 99%

“…1 The presence of cisplatin in waters and wastewaters has been reported. The excretion via faeces and urine of patients under medical treatment and disposal of unused pharmaceuticals, [2][3][4] effluents from hospitals [5][6][7][8] and wastewaters generated during the pharmaceutical manufacturing process, 9 represent the major contamination sources for this cytostatic.…”

Section: Cisplatin Cis-diamminedichloroplatinum(ii)mentioning

confidence: 99%

Optimization of a HPLC procedure for simultaneous determination of cisplatin and the complex cis,cis,trans-diamminedichlorodihydroxoplatinum(IV) in aqueous solutions

et al. 2011

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Recebido em 10/9/10; aceito em 1/3/11; publicado na web em 5/5/11 A RP-HPLC procedure for the simultaneous determination of cisplatin and the complex cis,cis,trans-diamminedichlorodihydroxoplatinum(IV), was development. The developed procedure was validated in terms of linearity, accuracy, precision, limits of detection (LOD), limits of quantification (LOQ) and specificity. The limits of detection (LOD) , for cisplatin and cis,cis,trans-diamminedichlorodihydroxoplatinum(IV), respectively. The average recoveries of cisplatin and cis,cis,trans-diamminedichlorodihydroxoplatinum(IV) was 100.6% ± 1.4 and 101.2% ± 1.1, respectively. Intermediate (inter-day) precision, repeatability and specificity of the procedure for hydrolysis products of cisplatin were studied. The results of the study showed that the proposed RP-HPLC procedure is simple, rapid, precise, accurate and specific.

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“…Hann et al studied low concentrations of cisplatin (Hann et al, 2003b, oxaliplatin , and carboplatin and their degradation products in water containing varying concentrations of chloride and in human urine in order to support the development of elimination procedures as well as toxicological studies (Hann et al, 2003a. Lenz et al (2007) investigated the metabolism and adsorption of Pt compounds in biological waste water. These methods are summarized in Table 6.…”

Section: Speciation Of Metal-based Anticancer Compounds In Environmenmentioning

confidence: 99%

The application of inductively coupled plasma mass spectrometry in clinical pharmacological oncology research

Brouwers

Tibben

Rosing

et al. 2008

Mass Spectrometry Reviews

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Metal-based anticancer agents are frequently used in the treatment of a wide variety of cancer types. The monitoring of these anticancer agents in biological samples is important to understand their pharmacokinetics, pharmacodynamics, and metabolism. In addition, determination of metals originating from anticancer agents is relevant to assess occupational exposure of health care personnel working with these drugs. The high sensitivity of inductively coupled plasma mass spectrometry (ICP-MS) has resulted in an increased popularity of this technique for the analysis of metal-based anticancer drugs. In addition to the quantitative analysis of the metal of interest in a sample, ICP-MS can be used as an ultrasensitive metal selective detector in combination with speciation techniques such as liquid chromatography. In the current review we provide a systematic survey of publications describing the analysis of platinum-and ruthenium-containing anticancer agents using ICP-MS, focused on the determination of total metal concentrations and on the speciation of metal compounds in biological fluids, DNA-and protein-adducts, and environmental samples. We conclude that ICP-MS is a powerful tool for the quantitative analysis of metal-based anticancer agents from multiple sample sources.

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Fate of cancerostatic platinum compounds in biological wastewater treatment of hospital effluents

Cited by 113 publications

References 12 publications

Bio-Reclamation of Strategic and Energy Critical Metals from Secondary Resources

Bio-Reclamation of Strategic and Energy Critical Metals from Secondary Resources

Optimization of a HPLC procedure for simultaneous determination of cisplatin and the complex cis,cis,trans-diamminedichlorodihydroxoplatinum(IV) in aqueous solutions

The application of inductively coupled plasma mass spectrometry in clinical pharmacological oncology research

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