Fate of Erythromycin in Sediment-Containing Surface Water Microcosms: How Does Aged Erythromycin in Sediment Influence Bioavailability?

Jessick, Ashley M.; Coats, Joel R.

doi:10.1021/bk-2013-1126.ch007

Cited by 4 publications

(2 citation statements)

References 37 publications

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“…After application, antibiotics can be transported through different pathways. Sorption has been considered as the major process governing the mobility and transport of antibiotics in environment [ 5 ], while in the meantime evidence is increasing that sequestration in particular, and bound-residue formation largely control the long-term storage of antibiotics in soils and sediments (e.g., [ 13 , 14 , 15 ]). The dissipation half-life of antibiotics may thus vary considerably, depending on the compound, degradation pathway and environmental media.…”

Section: Introductionmentioning

confidence: 99%

Occurrence and Dissipation of the Antibiotics Sulfamethoxazole, Sulfadiazine, Trimethoprim, and Enrofloxacin in the Mekong Delta, Vietnam

et al. 2015

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The Mekong Delta in Vietnam has seen a rapid development and intensification of aquaculture in the last decades, with a corresponding widespread use of antibiotics. This study provides information on current antibiotic use in freshwater aquaculture, as well as on resulting antibiotic concentrations in the aquatic environment of the Mekong Delta. Two major production steps, fish hatcheries and mature fish cultivation, were surveyed (50 fish farm interviews) for antibiotic use. Different water sources, including surface water, groundwater and piped water (164 water samples) were systematically screened for antibiotic residues. To better understand antibiotic fate under tropical conditions, the dissipation behavior of selected antibiotics in the aquatic environment was investigated for the first time in mesocosm experiments. None of the investigated antibiotics were detected in groundwater and piped water samples. Surface water, which is still often used for drinking and domestic purposes by local populations, contained median concentrations of 21 ng L-1 sulfamethoxazole (SMX), 4 ng L-1 sulfadiazine (SDZ), 17 ng L-1 trimethoprim (TRIM), and 12 ng L-1 enrofloxacin (ENRO). These concentrations were lower than the predicted no effect concentrations (PNECs) and minimum inhibitory concentrations (MICs), suggesting limited antibiotic-related risk to aquatic ecosystems in the monitored systems. The dissipation half-lives of the studied antibiotics ranged from <1 to 44 days, depending on the availability of sunlight and sediment. Among the studied antibiotics TRIM was the most persistent in water systems. TRIM was not susceptible to photodegradation, while the dissipation of ENRO and SDZ was influenced by photolysis. The recorded dissipation models gave good predictions of the occurrence and concentrations of TRIM, ENRO and SDZ in surface water. In summary, the currently measured concentrations of the investigated antibiotics are unlikely to cause immediate risks to the aquatic environment, yet the persistence of these antibiotics is of concern and might lead to chronic exposure of aquatic organisms as well as humans.

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Section: Introductionmentioning

confidence: 99%

Occurrence and Dissipation of the Antibiotics Sulfamethoxazole, Sulfadiazine, Trimethoprim, and Enrofloxacin in the Mekong Delta, Vietnam

et al. 2015

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“…In a similar assessment of antibiotic residues in the water environment, high residues of sulfamethoxazole, norfloxacin and Oxolinic acid which are important agents in the treatment of human and animal infections were found [71]. The discharge of antibiotics from human or human activity is not the end process to the antibiotics because reports have it that not all antibiotics in the environment are being degraded, for instance, fluoroquinolones are known to persist long in the environment as reported by previous studies [72,73]. Sukul and Spiteller [74] also reported the occurrence of a significant amount of fluoroquinolones in groundwater, which is believed to have reached such environments as waste from urine, faeces, fertilizer or discharge from hospitals.…”

Section: How Water Environment Contributes To Spread Of Resistancementioning

confidence: 58%

Environmental contribution to antimicrobial resistance: A largely ignored global health issue

Mustapha

Allamin

Ismail

et al. 2021

PNgAS

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Environmental contribution to the continued occurrence of antibiotic resistance has been largely unexplored. There has been much focus on clinical isolates for their resistant nature but non-clinical bacterial isolates in the environment have been considered as the chief contributing factors that facilitate the spread and dissemination of antibiotic-resistant bacteria (ABR) and antibiotic-resistant genes (ARGs). The natural environment acts as a reservoir for bacteria, providing them with a favourable condition for their emergence and breeding of resistance. One such environmental leverage is inter/intra-specie exchange of genes encoding resistance factors. It was argued that human activities aid immensely in the emergence of antibiotic resistance in the environment. The rationale for this review is to examine extensively the complex interplay of antibiotic resistance from the natural environmental perspective and factors that influence the occurrence and dissemination of such resistance. It also seeks to stress the biological factors that facilitate the emergence of resistance and link it to general biological processes. The review has been structured to capture the general threat posed by the circulation of antibiotic-resistant bacteria and their genes, as well as the influence of the environment in contributing to this global health threat. In addition, the review looked at the effective methods used to tackle the silent pandemic, by controlling the spread of resistance in the environment. Environmental stakeholders and policymakers are recommended to be included in tackling the development of antibiotic resistance.

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Global review and analysis of erythromycin in the environment: Occurrence, bioaccumulation and antibiotic resistance hazards

Schafhauser

Kristofco

Oliveira

et al. 2018

Environmental Pollution

139

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Environmental observations of antibiotics and other pharmaceuticals have received attention as indicators of an urbanizing global water cycle. When connections between environment and development of antibiotic resistance (ABR) are considered, it is increasingly important to understand the life cycle of antibiotics. Here we examined the global occurrence of erythromycin (ERY) in: 1. wastewater effluent, inland waters, drinking water, groundwater, and estuarine and coastal systems; 2. sewage sludge, biosolids and sediments; and 3. tissues of aquatic organisms. We then performed probabilistic environmental hazard assessments to identify probabilities of exceeding the predicted no-effect concentration (PNEC) of 1.0 μg L for promoting ABR, based on previous modeling of minimum inhibitory concentrations and minimal selective concentrations of ERY, and measured levels from different geographic regions. Marked differences were observed among geographic regions and matrices. For example, more information was available for water matrices (312 publications) than solids (97 publications). ERY has primarily been studied in Asia, North America and Europe with the majority of studies performed in China, USA, Spain and the United Kingdom. In surface waters 72.4% of the Asian studies have been performed in China, while 85.4% of the observations from North America were from the USA; Spain represented 41.9% of the European surface water studies. Remarkably, results from PEHAs indicated that the likelihood of exceeding the ERY PNEC for ABR in effluents was markedly high in Asia (33.3%) followed by Europe (20%) and North America (17.8%). Unfortunately, ERY occurrence data is comparatively limited in coastal and marine systems across large geographic regions including Southwest Asia, Eastern Europe, Africa, and Central and South America. Future studies are needed to understand risks of ERY and other antibiotics to human health and the environment, particularly in developing regions where waste management systems and treatment infrastructure are being implemented slower than access to and consumption of pharmaceuticals is occurring.

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Fate of Erythromycin in Sediment-Containing Surface Water Microcosms: How Does Aged Erythromycin in Sediment Influence Bioavailability?

Cited by 4 publications

References 37 publications

Occurrence and Dissipation of the Antibiotics Sulfamethoxazole, Sulfadiazine, Trimethoprim, and Enrofloxacin in the Mekong Delta, Vietnam

Occurrence and Dissipation of the Antibiotics Sulfamethoxazole, Sulfadiazine, Trimethoprim, and Enrofloxacin in the Mekong Delta, Vietnam

Environmental contribution to antimicrobial resistance: A largely ignored global health issue

Global review and analysis of erythromycin in the environment: Occurrence, bioaccumulation and antibiotic resistance hazards

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