“…For instance, it has been the sixth most abundant pharmaceutical detected in the influent flow of wastewater treatment plants (WWTPs) in Italy . Although it is susceptible to biodegradation (Tiehm et al, 2011;de Graaf et al, 2011), IBP is only partially removed by WWTPs (Oulton et al, 2010;Morasch et al, 2010) and the treatment efficiency undergoes a considerable decrease during the winter months Santos et al, 2009), when the IBP environmental inputs tend to increase considerably (Daneshvar et al, 2010). The combination of widespread use and incomplete WWTP elimination results into an extensive occurrence of IBP in surface waters.…”