Fate of registered clinical trials performed in Saudi Arabia

Jamjoom, Abdulhakim B.; Jamjoom, Ammer M.; Samman, Afnan M.; Gahtani, Abdulhadi Y

doi:10.15537/smj.2015.10.12506

Cited by 6 publications

(7 citation statements)

References 5 publications

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“…This study revealed that many studies were funded by an international pharmaceutical company. This trend is consistent with the results of the previous studies ( Jamjoom et al, 2015 , Ali et al, 2017 ). The benefits of the globalization of clinical research such as ethnic diversity decreased study cost, improved recruitment, and access to rare diseases may act as a stimulating force to increase the number of studies in our region ( Nair et al, 2013 ).…”

Section: Discussionsupporting

confidence: 94%

“…Clinical research in the KSA has made progressions during the last few years. Saudi researchers have contributed to the medical literature by piloting different types of research, including investigator-initiated CTs and international multicenter-sponsored CTs ( Jamjoom et al, 2015 , Al-Rawashdeh et al, 2019 ). The number of clinical trials in any country reflects the advancement of a healthcare system ( Ali et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

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The Characteristics of Clinical Studies Submitted to the Saudi Food and Drug Authority from 2009 until 2020

Aljawadi

Aldhahri

Almetwazi

et al. 2021

Saudi Pharmaceutical Journal

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Background Clinical trials are crucial in contemporary evidence-based medicine for discovering new treatments for diseases. Their registration in a registry increases the transparency in the dissemination of knowledge about clinical research. It is essential to understand the activity of clinical trials in a country, thus identifying research gaps. Objective This study, therefore, aims to describe the clinical trial activity since the inception of clinical trials’ administration and national clinical trials’ registry within the Kingdom of Saudi Arabia (KSA). Method A descriptive study was conducted by reviewing all clinical studies that have been registered during 2009 and June 2020. The inclusion criterion was all phases of the clinical trials registered in the national registry during that period. Data analysis was done using descriptive statistics. Results Since 2009, 352 studies have been registered. However, a total of 333 studies with complete data was included in the analysis. A total of 80 sponsors funded the clinical studies in the KSA. The majority of the clinical studies are funded by multinational pharmaceutical companies. Oncology (13.81%) and diabetes (11.71%) were the most common therapeutic areas and constituted the largest proportion of the overall studies. 44% were phase 4 and 40% were phase 3 studies. Conclusion With a population approaching 34 million, the number of clinical trials in the KSA is not sufficient. Since the inception of the clinical trial’s administration and SCTR, the emphasis has been on phase 3 and phase 4 clinical studies. The most studied therapeutic areas were oncology and diabetes. Many clinical studies in the KSA were sponsored by multinational pharmaceutical companies.

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Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

The Characteristics of Clinical Studies Submitted to the Saudi Food and Drug Authority from 2009 until 2020

Aljawadi

Aldhahri

Almetwazi

et al. 2021

Saudi Pharmaceutical Journal

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show abstract

Section: Introductionmentioning

confidence: 99%

“…Clinical research in the Kingdom of Saudi Arabia (KSA) has made advancements during the last few decades 15. Saudi researchers have contributed to medical literature by conducting different types of research, including investigator-initiated CTs and international multicenter-sponsored CTs 15. Measuring the Saudi public’s knowledge of and attitudes toward CTs is crucial for assessing their acceptance of CTs and to provide an evidence base to improve CT recruitment and decision-making.…”

Section: Introductionmentioning

confidence: 99%

Knowledge of and attitudes toward clinical trials in Saudi Arabia: a cross-sectional study

et al. 2019

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ObjectivesClinical trials (CTs) are considered an important method for developing new treatments and providing access to potentially effective drugs that are still under investigation. Measuring the public’s knowledge of and attitudes toward CTs is important for assessing their readiness for and acceptance of human drug testing, which has previously not been assessed in the Kingdom of Saudi Arabia (KSA). The objective of this study is to explore the Saudi public’s knowledge of and attitudes toward CTs as well as participation in trials to test new or approved drugs.DesignCross-sectional.SettingThe 2016 Al Jenadriyah cultural/heritage festival in Riyadh, KSA.ParticipantsParticipating booths and exhibition halls, as well as festival visitors, were approached to participate in the study.Primary and secondary outcome measuresKnowledge of and attitudes toward CTs.ResultsThe final number of participants was 938. The responses were converted to a percentage mean score (out of 100) for each knowledge-related response and attitude. The total mean knowledge score was 56.8±24.8 and the attitude-related score was 61.5±28.0. Although most of the participants supported testing approved or off-label and new drugs on adult and paediatric patients, only a third (30.5%) agreed that new drugs could be tested on healthy volunteers. The results indicated that gender, educational level, income, medical background, age and health insurance were independently associated with the level of knowledge of CTs. In terms of attitudes toward CTs, the factors that were independently associated were gender, educational level and medical background.ConclusionsThe Saudi public has a low level of knowledge and a moderately positive attitude toward CTs. There is a moderate positive correlation between the two factors such that as knowledge of CTs increases, the Saudi public will hold more positive attitudes toward CTs.

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“…Schistosomes are blood flukes, which are trematode worms with complex multicellular nature (Edward and Andrew, 2002). Six species of Schistosoma have been recognized in human cases of schistosomiasis, which include Schistosoma haematobium, Schistosoma mansoni, Schistosoma japonicum, Schistosoma intercalatum, Schistosoma mekongi and Schistosoma guineensis (Jamjoom, 2006;Clerinx and Soentjens, 2017).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of urinary schistosomiasis among school children in Giwa and Markafi Local Government Areas, Kaduna State, Nigeria

Markus,

Bishop

2024

SWJ

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Urinary schistosomiasis is a neglected tropical disease that is affecting the health of many children, especially in Nigeria. Awareness about schistosomiasis in some communities is low; hence more children undertake activities in unsafe bodies of water. This study determined the prevalence, socio-demography, risk factors and symptoms of urinary schistosomiasis among school children in Giwa and Makarfi LGAs. A total of 200 school children were enrolled in this study and each of them submitted 10 mL urine sample. Each urine sample was concentrated by centrifugation and the sediment was examined using a light compound microscope. Data collected were analyzed using IBM SPSS Version 23 at 95% confidence interval. Overall prevalence of urinary schistosomiasis in this study was 19(9.5%). Spatial prevalence was 10.0% and 9.0% in Giwa and Makarfi LGAs respectively. There was no infection among the females (0.0%), but 13.5% of infection occurred among the males (P=0.003, OR =1.156). School children within the age-group of 18–19 years old had highest infection of 20.0%, followed by 12.1% and 5.6% among those within age-groups of 14-15 and 12-13 years old respectively. The infection was more occurring among children in junior secondary school (10.4%) than among those in senior secondary school (7.7%). Significant risk factors were irrigation farming, swimming, fishing and washing of clothes in rivers (P<0.05, OR >1). Significant symptoms of the disease among them included painful urination and terminal haematuria (P<0.05, OR >1). However, infected individuals mostly encountered frequent urination and abdominal pains (OR>1). Urinary schistosomiasis prevails in the study area. It is important to create widespread awareness and treatment intervention.

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Fate of registered clinical trials performed in Saudi Arabia

Cited by 6 publications

References 5 publications

The Characteristics of Clinical Studies Submitted to the Saudi Food and Drug Authority from 2009 until 2020

The Characteristics of Clinical Studies Submitted to the Saudi Food and Drug Authority from 2009 until 2020

Knowledge of and attitudes toward clinical trials in Saudi Arabia: a cross-sectional study

Prevalence of urinary schistosomiasis among school children in Giwa and Markafi Local Government Areas, Kaduna State, Nigeria

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