Fate of Surviving Low-birth-weight Infants with Coagulation Deficiencies on the First Day of Life

Bryant, Gillian M.; Gray, O.P.; Fraser, A. J.; Ackerman, A.

doi:10.1136/bmj.4.5737.707

Cited by 6 publications

(4 citation statements)

References 5 publications

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“…Nevertheless, it cannot be assumed that such infants escape unscathed from the hypoxic episode, since the very process which caused the consumption of coagulation factors results in deposition of fibrin, and this may have led to damage of vital organs such as the brain. That damage can result is suggested by a recent report (Bryant et al, 1970) and further work is being conducted in this centre to evaluate this possible effect.…”

Section: Discussionmentioning

confidence: 85%

Coagulation Defects in Hypoxic Full-term Newborn Infants

Chadd¹,

Elwood²,

Gray³

et al. 1971

BMJ

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gross infiltration, those with nodular lesions, and among those with high bacillary density on skin smears.The very detailed monthly assessment of haematological, hepatic, renal, neurological, visual, and cardiac functions failed to show any toxic effects from clofazimine during the period of observation, and thus confirmed the previously gained impression that in the acutely ill, debilitated leprosy patient clofazimine can be safely administered with gratifying therapeutic results. However, the red-brown pigmentation of the skin that was seen in all the patients, coupled with reddish brown urine and sweat and a tendency to development of dry scaly skin, was disturbing to the younger and fairer patients.The study does not show the superiority of clofazimine over dapsone, in the dose used in this trial, in terms of bacterial death and clearance, resolution of skin lesions, and the incidence of erythema nodosum leprosum. While further controlled studies for a longer period are necessary, we suggest that dapsone, which is much cheaper and does not cause significant pigmentation, is preferable to clofazimine in the routine management of untreated lepromatous leprosy. Clofazimine could be reserved for patients who are either sensitive or resistant to dapsone as well as for those who are distressed by recurrent chronic erythema nodosom leprosum or recurrent chronic peripheral neuritis or both.

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Section: Discussionmentioning

confidence: 85%

Coagulation Defects in Hypoxic Full-term Newborn Infants

Chadd¹,

Elwood²,

Gray³

et al. 1971

BMJ

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“…There have been several reports of disseminated intravascular coagulation in intrauterine fetal growth retardation and in cases of perinatal asphyxia (Bryant et al, 1970;Chadd et al, 1971). Howie et al, (1971) were unable to show changes in the haemostatic mechanism in maternal blood when comparing a low birth weight infant group with a normal group.…”

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confidence: 99%

Components of the Haemostatic Mechanism at Birth in Pre‐eclampsia With Particular Reference to Fetal Growth Retardation

Condie

1976

BJOG

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A comparative study of proteinuric pre-eclampsia and normal pregnancy has been carried out to assess changes in the haemostatic mechanism in maternal and umbilical vein blood at birth. The results demonstrated changes in pre-eclampsia compatible with hypercoagulability with, in particular, depressed fibrinolysis. No strong pattern of differences from normal pregnancy or pre-eclampsia emerged when growth retarded infants were studied as a separate group.

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“…The radiological appearance in the left kidney suggests that partial medullary necrosis occurred. This causes sodium loss, but not usually massive haematuria, and renal function generally returns to normal (Crispin, 1972 However, apart from the finding that some babies, who probably had disseminated intravascular coagulation, showed evidence of brain damage (Bryant et al, 1970), we have not found reports of permanent injury in those who have recovered. With better recognition and treatment of this condition the number of survivors will rise and impaired function of vital organs is likely to be detected more often.…”

Section: Commentmentioning

confidence: 67%

“…Treatment with heparin (Whaun, Ormson and Oski, 1971) or exchange transfusion (Gross and Melhorn, 1971) has been advocated, but the mortality is 60% (Whaun et al, 1971). Although fibrin deposits have been found in many organs at autopsy (Boyd, 1967) we have not found reports of permanent damage to organs other than the brain in the survivors (Bryant et al, 1970). Case report This baby girl was born at 42 weeks' gestation after an antepartum haemorrhage by normal vertex delivery in a nearby maternity home and weighed 3-85 kg.…”

Section: Introductionmentioning

confidence: 98%

Renal failure and suprarenal calcification after secondary haemorrhagic disease in a newborn baby

Moncrieff

Hargreaves

1975

Postgraduate Medical Journal

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Summary A newborn baby who was severely asphyxiated at birth developed secondary haemorrhagic disease which was treated successfully with intravenous heparin. However, she was later found to have supra-renal calcification, chronic renal insufficiency and hypertension. It is felt that prompt treatment of conditions that predispose to secondary haemorrhagic disease is very important as, once this has occurred, treatment may not prevent permanent damage to vital organs.

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Fate of Surviving Low-birth-weight Infants with Coagulation Deficiencies on the First Day of Life

Cited by 6 publications

References 5 publications

Coagulation Defects in Hypoxic Full-term Newborn Infants

Coagulation Defects in Hypoxic Full-term Newborn Infants

Components of the Haemostatic Mechanism at Birth in Pre‐eclampsia With Particular Reference to Fetal Growth Retardation

Renal failure and suprarenal calcification after secondary haemorrhagic disease in a newborn baby

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