Fate of tetrachlorvinphos and its isomer in soluble fraction (105000g) from goose and turkey liver homogenates

Akhtar, M. Humayoun; Foster, Thomas S.

doi:10.1021/jf60230a008

Cited by 5 publications

(1 citation statement)

References 12 publications

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“…GSTs, the homo or heterodimers with each subunit having a molecular weight of 24-28 kDa, catalyze the reaction of glutathione at the electrophilic site of a pesticide and its metabolites, 83) as reported for the O-demethylation of many OP pesticides. 52,84,85) The intact glutathione conjugate has been detected rarely in the avian metabolism, 86,87) due to the successive metabolism by peptidases and N-acetyltransferases finally to form a mercapturic acid conjugate. 83) When the herbicide propachlor was orally administered to hens, the cysteine and mercapturic acid conjugated via the reaction of glutathione at the chloromethyl carbon were detected as the main metabolites in the excreta.…”

Section: Glutathione S-transferases (Gst)mentioning

confidence: 99%

Acute toxicity and metabolism of pesticides in birds

Katagi

Fujisawa

2021

J. Pestic. Sci.

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The median lethal dose of pesticide in acute oral toxicity, used as a conservative index in avian risk assessment, varies by the species with differences of less than one order of magnitude, depending on body size, feeding habit, and metabolic enzyme activity. The profiles of pesticide metabolism in birds with characteristic conjugations are basically common to those in mammals, but less information is available on their relevant enzymes. The higher toxicity of some pesticides in birds than in mammals is due to the lower activity of avian metabolic enzymes. The bioaccumulation in birds is limited for very hydrophobic pesticides resistant to metabolic degradation. Several in silico approaches using the descriptors of a pesticide molecule have recently been employed to estimate the profiles of acute oral toxicity and bioaccumulation.

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Section: Glutathione S-transferases (Gst)mentioning

confidence: 99%

Acute toxicity and metabolism of pesticides in birds

Katagi

Fujisawa

2021

J. Pestic. Sci.

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The in‐vivo metabolism of propetamphos by insecticide‐resistant and susceptible strains of the housefly, Musca domestica

1986

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The metabolism of propetamphos by insecticide-resistant and susceptible houseflies, in vivo, was investigated. Two major pathways of propetamphos degradation were found. The first is the major route of detoxification for both resistant and susceptible strains at low doses and involves a hydrolysis of the P-0-vinyl bond, ultimately resulting in the formation of carbon dioxide. The second major pathway involves conjugation. As the dose increases, so does the importance of this pathway. Those strains of houseflies with greater conjugative capacity are able to tolerate greater doses of propetamphos than those strains with lesser conjugative capacity. The properties exhibited by this conjugate are consistent with those of glutathione conjugates. This is further supported by a parallel between reported values of glutathione S-transferase activity in the houseflies tested and tolerance to propetamphos.

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Potential misidentification of trichlorophenylethanol in imported peppers

Cairns

Siegmund

Barry

et al. 1990

Rapid Comm Mass Spectrometry

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During regulatory analyses for the determination of pesticide residues on agricultural commodities, a frequently encountered trichlorinated compound was misidentified by the NBS library search routine. This case history illustrates the need for more rigorous confirmation criteria when dealing with multi-chlorinated compounds where fragmentation can be dominated by methyl loss followed by loss of CO and HCI.

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Fate of tetrachlorvinphos and its isomer in soluble fraction (105000g) from goose and turkey liver homogenates

Cited by 5 publications

References 12 publications

Acute toxicity and metabolism of pesticides in birds

Acute toxicity and metabolism of pesticides in birds

The in‐vivo metabolism of propetamphos by insecticide‐resistant and susceptible strains of the housefly, Musca domestica

Potential misidentification of trichlorophenylethanol in imported peppers

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