“…3 Therefore, these lateral canals comprise pathways through which bacteria, and their byproducts, might reach the periodontal ligament and cause disease. 3 Due to the natural anatomical configuration of lateral canals and other complex anatomies, appropriate endodontic therapies to effectively debride, disinfect, and obturate are required to close the pathways of infection to the periodontal ligament, and thus prevent the initiation or exacerbation of apical periodontitis. Complex anatomy is difficult to predict and detect preoperatively, thus making these naturally occurring morphologies and varying canal configurations a challenge for debridement, disinfection, and obturation.…”