Context: One of the serious global problems is the irrational prescribing of medicines that can be regarded as harmful or wasteful. Inappropriate use and overuse of medicines, waste resources and therefore lead to health and economic consequences in patients. The goal of this systematic review was to identify factors associated with irrational prescriptions of medicine.Evidence Acquisition: We searched the Cochrane database of systematic reviews (via Cochrane library), PubMed, Medline, Scopus, Science Direct, BMC, Scholar Google, and SID from 1980 up to October of 2016.
Results:Of the 594 papers, 26 papers were finally included. The combined results of the 26 papers indicated 24 factors for unnecessary prescriptions of medicine. Factors related to the patient were expectations, demand to prescribe, and poor medical knowledge. Factors related to the physician were inaccurate diagnosis, inadequate awareness and knowledge, low experience, information asymmetry, poor medical education, and the physician's attitude. Factors related to the institutional and political issues were fee-for-service, out-of-pocket payment, financial incentives, insurance reimbursements, insurance coverage, medicine subside, medicine advertisement, ineffective monitoring programs, regulation on prescription, prescription supervision, clinical guidance, and medicines near-expiry dates or expired.
Conclusions:It can be concluded that the irrational/unnecessary prescription of medicine was influenced by many different factors, such as patient, physician, and institution. Thus to prevent irrational/unnecessary prescription, one needs to consider all the involved factors.Keywords: Drug Prescriptions, Prescriptions, Physician-Patient Relations
ContextDifferent forms of irrational prescription include misuse, abuse, overuse, and polypharmacy. One of the serious global problems is irrational prescribing of medicines that can be considered as harmful and/or wasteful (1). While patients have the choice to select their doctors, doctors have the choice to decide on the kind of diagnosis and the quantity of health services patients consume. In other words, the doctor is the first gate to medicine use (2, 3). However, because of the patient's inadequate information about medicine, the physician has the possibility to influence both the kind of diagnosis and the number of health services provided, as well as possibly the number of visits (4-8). Physician-induced demand clearly implies an effort to persuade patients to overuse services (4, 9-12). According to WHO reports, more than 50% of all medicines are inappropriately prescribed or sold, and nearly half of the patients do not take them appropriately (13). The report shows that patients are treated better in public sectors than private ones based on standard clinical guidelines (1). Ramezankhani et al. in a study on assessing the medicine prescriptions of health care centers, found out that prescription of medicine in the private sector was more than that of the public sector due to better monit...