Fatigue after treatment in breast cancer survivors: prevalence, determinants and impact on health-related quality of life

Kluthcovsky, Ana Cláudia Garabeli Cavalli; Urbanetz, Almir Antônio; Carvalho, Denise Siqueira de; Maluf, Eliane Mara Cesário Pereira; Sylvestre, Geovana Cristina Schlickmann; Hatschbach, Sérgio Bruno Bonatto

doi:10.1007/s00520-011-1293-7

Cited by 78 publications

(59 citation statements)

References 40 publications

(63 reference statements)

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“…Possible causal factors include physical conditions, affective and cognitive states, pro-inflammatory cytokines, and metabolic factors 7 . In the present study, higher fatigue scores for survivors were most strongly related to the physical domain of quality of life, reinforcing the findings that physical symptoms (such as pain, dyspnea, insomnia, and nausea and vomiting) serve as predictors of fatigue in breast cancer survivors 30 .…”

Section: Discussionsupporting

confidence: 88%

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Fatigue and quality of life in breast cancer survivors: a comparative study

Kluthcovsky¹,

Urbanetz²

2015

Rev. Bras. Ginecol. Obstet.

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PURPOSE: To assess fatigue and quality of life in disease-free breast cancer survivors in relation to a sample of age-matched women with no cancer history and to explore the relationship between fatigue and quality of life. METHODS: A cross-sectional study was conducted in a sample of 202 consecutive disease-free Brazilian breast cancer survivors, all of whom had completed treatment, treated at 2 large hospitals. The patients were compared to age-matched women with no cancer history attending a primary health care center. The Piper Fatigue Scale-Revised and the World Health Organization Quality of Life Instrument (WHOQOL-BREF) were used to measure the fatigue and quality of life, respectively. Socio-demographic and clinical variables were also obtained. The χ 2 test, generalized linear model, and Spearman correlation coefficient were used for statistical purposes. The adopted level of significance was 5%. RESULTS: Breast cancer survivors experienced significantly greater total and subscale fatigue scores than comparison group (all p-values<0.05). In addition, survivors reported a poorer quality of life in physical (p=0.002), psychological (p=0.03), and social relationships (p=0.03) domains than comparison group. No difference was found for the environmental domain (p=0.08) for both groups. For survivors of breast cancer and for comparison group, the total and subscale fatigue scores were related to lower quality of life (all p-values<0.01). CONCLUSION: The findings of this study highlight the importance of assessing fatigue and quality of life in breast cancer survivors. ResumoOBJETIVO: Avaliar a fadiga e a qualidade de vida de sobreviventes de câncer de mama, livres da doença, em relação a uma amostra de mulheres da mesma idade, sem histórico de câncer, e explorar a relação entre fadiga e qualidade de vida. MÉTODOS: Estudo transversal realizado com uma amostra consecutiva de 202 pacientes brasileiras, sobreviventes de câncer de mama e livres da doença, que haviam completado o tratamento em 2 grandes hospitais. As pacientes foram comparadas com mulheres da mesma idade, sem história de câncer, acompanhadas em uma Unidade Básica de Saúde. A Escala de Fadiga de Piper-Revisada e o World Health Organization Quality of Life Instrument (WHOQOL-BREF) foram usados para avaliar a fadiga e a qualidade de vida, respectivamente. Dados sociodemográficos e clínicos também foram obtidos. O teste do χ 2 , modelo linear generalizado e coeficiente de correlação de Spearman foram utilizados para fins estatísticos. Foi adotado o nível de significância de 5%. RESULTADOS: As sobreviventes de câncer de mama apresentaram significativamente maiores escores de fadiga total e das subescalas do que o grupo controle (todos os valores de p<0,05). Além disso, as sobreviventes relataram pior qualidade de vida nos domínios físico (p=0,002), psicológico (p=0,03) e relações sociais (p=0,03) do que o grupo controle. Nenhuma diferença foi encontrada para o domínio ambiental (p=0,08) entre os 2 grupos. Para as sobreviventes de câncer de mama...

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Section: Discussionsupporting

confidence: 88%

“…Fatigue in breast cancer survivors 30 and quality of life in breast cancer survivors compared to healthy women 31 were previously described. This cross-sectional study involves breast cancer survivors and a comparison group of age-matched women with no cancer history.…”

Section: Participants and Proceduresmentioning

confidence: 99%

Fatigue and quality of life in breast cancer survivors: a comparative study

Kluthcovsky¹,

Urbanetz²

2015

Rev. Bras. Ginecol. Obstet.

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“…The surveyed women reported an acceptable level of satisfaction with their current follow-up care, but also described ongoing social, emotional, and informational support needs. Respondents to our survey reported various physical side effects after breast cancer treatment that mirror those found in all women, independent of ethnicity 17,20,30 . Fatigue was especially prevalent, being the physical symptom that negatively affected them the most.…”

Section: Discussionmentioning

confidence: 71%

“…Other elements universal in women of all ethnic backgrounds included psychosocial issues such as fear of recurrence and depression. Indeed, fear of recurrence has often been identified in studies as a common response and a prevalent unmet need 5,[30][31][32][33][34] . Depression was documented as the issue causing greatest negative effect on quality of life for the women participating in the present study.…”

Section: Discussionmentioning

confidence: 99%

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Perceptions of Survivorship Care among South Asian Female Breast Cancer Survivors

Singh-Carlson

Nguyen²,

Wong³

2013

Current Oncology

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ConclusionsMany of the impacts of breast cancer treatment are shared by women of all ethnic backgrounds. Others-such as high levels of compliance, little reported strain on spousal and family relationships, and the importance of faith-reflect specific cultural variations. These universal and culture-specific themes should all be kept in mind when developing a scp tailored to sa women. The developmental life stage of a woman affects how she views the cancer diagnosis, especially with respect to family, reproduction, and work issues. KEY WORDSBreast cancer survivors, survivorship care plans, follow-up cancer care, South Asian

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