Fatigue and cognitive impairment after COVID-19: A prospective multicentre study

Hartung, Tim; Neumann, Christian; Bahmer, Thomas; Chaplinskaya-Sobol, Irina; Endres, Matthias; Geritz, Johanna; Hæusler, Karl Georg; Heuschmann, Peter U.; Hildesheim, Hanna; Hinz, Andreas; Hopff, Sina M.; Horn, Anna; Krawczak, Michael; Krist, Lilian; Kudelka, Jennifer; Lieb, Wolfgang; Maetzler, Corina; Mehnert‐Theuerkauf, Anja; Montellano, Felipe A.; Morbach, Caroline; Schreiber, Stefan; Steigerwald, Flo; Störk, Stefan; Maetzler, Walter; Finke, Carsten

doi:10.1016/j.eclinm.2022.101651

Cited by 121 publications

(94 citation statements)

References 44 publications

(64 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A recent study with 355 patients from a post-COVID outpatient clinic a , reported that over 90% reported signs of fatigue and depression and 23% performed below cut-off in a cognitive screening (Montreal Cognitive Assessment; MoCA 9 ). Similar incidences of below cut-off MoCA scores were reported following SARS-CoV-2 infection in a recent population-based study 10 .…”

Section: Introductionsupporting

confidence: 84%

Subtle cognitive impairments in memory, attention, and executive functioning in patients with post-COVID syndrome and their relationships with clinical variables and subjective complaints

Kozik

Reuken

Utech

et al. 2022

Preprint

View full text Add to dashboard Cite

Background and objectives. Cognitive symptoms persisting beyond 3 months following COVID-19 present a considerable disease burden. We aimed to establish a domain-specific cognitive profile of post-COVID syndrome, and relationships with clinical variables, to provide relevant information for outcome prediction and treatment decision-making. Methods. We compared cognitive performance on the Oxford Cognitive Screen-Plus between a large post-COVID cohort (n = 282) and a socio-demographically matched healthy control group (n = 52). We assessed task- and domain-level dysfunction and relationships between clinical and patient-reported outcomes. Results. Patients scored significantly lower on delayed verbal memory, attention, and executive functioning than healthy controls and in each of these domains, 10-20% of patients scored below cutoff. Delayed Memory was particularly affected and a rather small proportion of its variace was explained by hospitalization (β = -.67, p < .01) and age (β = -.03, p < .01; R2adj. = .06). Hospitalization further predicted attention performance (β = -.83, p < .001; R2adj. = .04). Interpretation. Post-COVID syndrome is associated with long-term cognitive dysfunction, particularly in delayed verbal memory, attention, and executive functioning, relatively independent of original disease severity. Next, longitudinal investigation of the domain-dysfunctions in this cohort is needed to examine their trajectory.

show abstract

Section: Introductionsupporting

confidence: 84%

Subtle cognitive impairments in memory, attention, and executive functioning in patients with post-COVID syndrome and their relationships with clinical variables and subjective complaints

Kozik

Reuken

Utech

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…In particular, executive functions, memory, and attention differ between post-COVID patients and healthy subjects [ 41 ]. Seven to nine months after acute infection, 24–29% of patients are still affected by cognitive deficits (e.g., memory encoding/memory recall, processing speed) [ 44 , 45 , 46 ]. Omar et al [ 43 ] showed that one to three months after infection, healthcare workers had significantly lower attention and memory scores than a healthy control group.…”

Section: Introductionmentioning

confidence: 99%

Impact of Rehabilitation on Physical and Neuropsychological Health of Patients Who Acquired COVID-19 in the Workplace

Müller

Poppele

Ottiger

et al. 2023

IJERPH

View full text Add to dashboard Cite

Workers, especially healthcare workers, are exposed to an increased risk for SARS-CoV-2 infection. However, less is known about the impact of rehabilitation on health outcomes associated with post-COVID. This longitudinal observational study examined the changes in physical and neuropsychological health and work ability after inpatient rehabilitation of 127 patients (97 females/30 males; age 21–69 years; Mean = 50.62) who acquired COVID-19 in the workplace. Post-COVID symptoms, functional status, physical performance, neuropsychological health, employment, and work ability were assessed before and after rehabilitation. Group differences relating to sex, professions, and acute COVID status were also analyzed. Except for fatigue, the prevalence of all post-COVID symptoms decreased after rehabilitation. Significant improvements in physical performance and neuropsychological health outcomes were determined. Moreover, healthcare workers showed a significantly greater reduction in depressive symptoms compared to non-healthcare workers. Nevertheless, participants reported poor work ability, and 72.5% of them were still unable to work after discharge from rehabilitation. As most participants were still suffering from the impact of COVID-19 at rehabilitation discharge, ongoing strategies in aftercare are necessary to improve their work ability. Further investigations of this study population at 6 and 12 months after rehabilitation should examine the further course of post-COVID regarding health and work ability status.

show abstract

“…During the COVID-19 pandemic, existing large scale citizen (population-based) cohorts such as the German National Cohort much like the newly established Corona Immunitas cohorts were able to provide insight into the course and determinants of the infections, the development of seroprevalence, the course and determinants of vaccination behavior, the adherence to and the impact of protective measures such as mask waring or social distancing, and the impact of containment measures on behavior, wellbeing and mental health trajectories [53][54][55][56][57][58][59]. If large cohorts exist, they can be used for very efficient evaluation of the course of the pandemic.…”

Section: Population Cohorts For Longitudinal Public Health Surveillancementioning

confidence: 99%

Swiss Cohort & Biobank – The White Paper

et al. 2022

View full text Add to dashboard Cite

A large Swiss Cohort with 100,000+ representative participants of all ages is the backbone of public health related research and an essential point of reference for health systems steering, personalized health, and clinical research. The national multidisciplinary public health sciences community of SSPH+ and the national society of public health professionals-the Swiss Society for Public Health-assembled an ad hoc Steering & Writing Committee led by Prof. Nicole Probst-Hensch, Swiss TPH to publish a White Paper in fall 2022. This is a further complementary step in the national move toward better health data in Switzerland and specifically toward a large population-based cohort and biobank, with its many milestones, including the cohort pilot study of the Federal Office of Public Health (FOPH), largely based on the protocols of the only national population-based cohort and biobank of Switzerland (SAPALDIA) running successfully since >30 years as well as draft questionnaires of HBM4EU, Food frequency questionnaires of MenuCH, worker exposure questionnaires, and others. Some protocols have been developed specifically the cohort pilot, e.g., all blood and urine sampling protocols. Moreover, the parliamentary petitions (Motion 19.4069 1 ; Postulat 21.3220 2 ) call for a Children Cohort as another crucial step in the promotion of more Swiss research for the health of the youngest.

show abstract

Fatigue and cognitive impairment after COVID-19: A prospective multicentre study

Cited by 121 publications

References 44 publications

Subtle cognitive impairments in memory, attention, and executive functioning in patients with post-COVID syndrome and their relationships with clinical variables and subjective complaints

Subtle cognitive impairments in memory, attention, and executive functioning in patients with post-COVID syndrome and their relationships with clinical variables and subjective complaints

Impact of Rehabilitation on Physical and Neuropsychological Health of Patients Who Acquired COVID-19 in the Workplace

Swiss Cohort & Biobank – The White Paper

Contact Info

Product

Resources

About