Fatigue and depression predict quality of life in patients with early multiple sclerosis: a longitudinal study

Nourbakhsh, Bardia; Julián, Laura; Waubant, Emmanuelle

doi:10.1111/ene.13102

Cited by 72 publications

(51 citation statements)

References 22 publications

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“…Importantly, this is the first study to identify severity of RLS as an important correlate of HRQOL and this association may be accounted for by fatigue, depression and anxiety. These results build upon current literature that identifies depression and fatigue as strong predictors of HRQOL in persons with MS (Amato et al., ; Fruehwald et al., ; Lobentanz et al., ; Nourbakhsh, Julian, & Waubant, ). Future research should consider other possible factors that may mediate the relationship between the severity of RLS symptoms and HRQOL in persons with MS.…”

Section: Discussionsupporting

confidence: 80%

Restless legs syndrome and health‐related quality of life in adults with multiple sclerosis

Cederberg

Jeng

Sasaki

et al. 2019

Journal of Sleep Research

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Restless legs syndrome (RLS) is a sleep disorder that may exacerbate many of the symptoms and consequences of multiple sclerosis (MS), and may have further implications for health‐related quality of life (HRQOL). The present study examined the relationships among RLS, symptoms and HRQOL in people with MS. Participants with MS (n = 275) completed the Cambridge‐Hopkins Restless Legs Syndrome Questionnaire, the International Restless Legs Syndrome Study Group Scale, the Multiple Sclerosis Impact Scale, the Pittsburgh Sleep Quality Index, the Fatigue Severity Scale, the Hospital Anxiety and Depression Scale and the Patient Determined Disease Steps. There were 74 (26.9%) persons with MS who had RLS (MS + RLS). The MS + RLS group reported worse physical and psychological HRQOL (p = 0.020 and p = 0.017, respectively) and greater perceived fatigue (p = 0.006) and anxiety symptoms (p = 0.042) than the MS‐only group. Within the MS + RLS group, RLS severity was associated with physical (r = 0.43) and psychological (r = 0.46) HRQOL, sleep quality (r = 0.38), perceived fatigue (r = 0.28), depression (r = 0.38) and anxiety (r = 0.28). The relationships between RLS severity and the domains of HRQOL were attenuated when accounting for fatigue, depression and/or anxiety. Worse RLS severity was associated with reduced HRQOL, which was accounted for by fatigue, depression and anxiety.

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Section: Discussionsupporting

confidence: 80%

Restless legs syndrome and health‐related quality of life in adults with multiple sclerosis

Cederberg

Jeng

Sasaki

et al. 2019

Journal of Sleep Research

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“…Studies have shown that mindfulness has been effective in improvement of mental and physical well-being and reduction of physical symptoms. 5,17,18 In another explanation, it can be noted that mindfulness is a balanced and non-judgmental feeling of awareness which helps the clarification and acceptance of physical and emotional phenomena. 17,18 …”

Section: Discussionmentioning

confidence: 99%

“…MS threatens a person’s independence and ability to effectively participate in society, on the one hand, 5 and its prognosis and unpredictable periods considerably affect quality of life and health, on the other hand.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Group Mindfulness-based Stress Reduction and Consciousness Yoga Program on Quality of Life and Fatigue Severity in Patients with MS

Nejati¹,

S²,

Rahmani³

et al. 2016

J Caring Sci

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Introduction: The chronic nature of Multiple Sclerosis (MS), have can leave devastating effects on quality of life and fatigue. The present research aimed to study the effect of group Mindfulness-based Stress Reduction (MBSR) and conscious yoga program on the quality of life and fatigue severity among patients with MS. Methods: This study was quasi-experimental with intervention and control groups. The statistical population included all members to MS Society of Tehran Province, 24 of whom diagnosed with MS were selected as the sample based on the inclusion criteria. The subjects were randomly assigned into the test group (12 patients) and the control group (12 patients). MS Quality of Life-54 (MSQOL-54) and Fatigue Severity Scale (FSS) were used for data collection. Subjects in the test group underwent a MBSR and conscious yoga program in 8 two-hour sessions. The data were analyzed using the SPSS ver.13 software. Results: The study findings showed that there was a significant difference between subjects in the experimental and control groups in terms of mean score of some subscales of quality of life including physical health, role limitations due to physical and emotional problems, energy, emotional well-being, health distress, health perception, and satisfaction with sexual function, overall quality of life, and fatigue severity. Conclusion: The results show that the program is effective in reduction of fatigue severity and improving some subscales of quality of life in MS patients. Hence, this supportive method can be used as an effective way for improving quality of life and relieving fatigue in MS patients.

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“…Patients with MS exhibiting depressive symptoms show increased propensity to experience cognitive symptoms, thus contributing to disability and disease duration [13]. Other studies have suggested that mood is a strong predictor of cognitive function [12, 25]. Specifically, depression was found to affect executive function [26].…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Psychosocial Factors and Cognition in Multiple Sclerosis

Alosaimi

AlMulhem

Moscovici

et al. 2017

Behavioural Neurology

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Introduction Multiple sclerosis (MS) is a common disorder in some regions of the world, with over 2.3 million people diagnosed worldwide. Cognitive impairment is one of the earliest symptoms to present in the course of the disease and can cause significant morbidity. We proposed a study to explore the psychosocial predictors of cognitive impairment in MS patients in Saudi Arabia, a previously unexplored patient population. Methods Demographic data, depression scale (PHQ9), symptom burden (PHQ15), anxiety (GAD7), disease duration, and Montreal Cognitive Assessment (MOCA) scores were collected from 195 patients in a neurology clinic in Ryiadh, Saudi Arabia. Univariate and multiple regression analyses were conducted to identify variables that are significantly associated with cognitive impairment. Results Variables that were identified to be significantly associated with cognition, p < 0.05, were education level, disease duration, and family history. Discussion Both education level and disease duration were variables identified in previous studies. We showed family history to be a significant variable, and no association was found with depression or anxiety, which is unique to our study population. Conclusions We identified several psychosocial predictors that are associated with cognition in our patient population. It was also noted that a difference exists between patient populations, highlighting the need for further studies in specific geographical regions.

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Fatigue and depression predict quality of life in patients with early multiple sclerosis: a longitudinal study

Abstract: Fatigue, depression, cognition and disability are independently associated with HRQoL in early MS.

Cited by 72 publications

References 22 publications

Restless legs syndrome and health‐related quality of life in adults with multiple sclerosis

Restless legs syndrome and health‐related quality of life in adults with multiple sclerosis

The Effect of Group Mindfulness-based Stress Reduction and Consciousness Yoga Program on Quality of Life and Fatigue Severity in Patients with MS

The Relationship between Psychosocial Factors and Cognition in Multiple Sclerosis

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