Fatigue and Mood States in Nursing Home and Nonambulatory Home-Based Patients with Multiple Sclerosis

Younus, Zilfah; Vaughn, Caila B.; Sanai, Shaik Ahmed; Kavak, Katelyn; Gupta, Sahil; Nadeem, Muhammad; Teter, Barbara; Noyes, Katia; Zivadinov, Robert; Edwards, Keith; Coyle, Patricia K.; Goodman, Andrew; Weinstock‐Guttman, Bianca

doi:10.7224/1537-2073.2016-058

Cited by 6 publications

(2 citation statements)

References 24 publications

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“…Severely-limited (non-ambulatory) pwMS that are living within a structured nursing home environment report significantly lower level of fatigue, pessimism and tension when compared to home-based care. 47 The periodic fluctuations in MS symptoms can also result with different answers on questionnaires depending on the period the pwMS was recruited and administered. For example, heat-sensitive pwMS may report higher levels of fatigability that could be related to the current meteorological temperatures (pwMS interviewed during winter versus summer months).…”

Section: Discussionmentioning

confidence: 99%

Neuroimaging Correlates of Patient-Reported Outcomes in Multiple Sclerosis

Jakimovski¹,

Wicks²,

Bergsland³

et al. 2023

DNND

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Background Patient-reported outcomes (PROs) are increasingly associated with concurrent and future impairments in persons with multiple sclerosis (pwMS). The structural and pathological relationships with PROs in pwMS have not been elucidated. Methods One hundred and forty-two pwMS and 47 healthy controls (HCs) were scanned using 3T MRI and completed a PRO questionnaire named Lifeware ® that outlines the physical and psychosocial abilities. Beck’s Depression Inventory (BDI) assessed levels of depression. T1- and T2-lesion volume, volumes of the whole brain (WBV), gray matter (GMV), white matter (WMV) and lateral ventricle (LVV) were derived using JIM and SIENAX software. Additional deep GM (DGMV) and nuclei-specific volumes of the thalamus, caudate, globus pallidus, putamen, and hippocampus were calculated using FIRST. Ordinal regression models adjusted for age and depression and mediation analyses were used. Results When compared to HCs, pwMS reported significantly greater limitations in mobility domains, including standing up from low seat (p < 0.001), climbing flight of stairs (p < 0.001), lower limb limitation (p < 0.001), limitations in bladder continence (p = 0.001) and fatigability (p < 0.001). Patient-reported limitations related to lower extremity function were explained by age, BDI, and all DGM nuclei volumes (p < 0.029). No such relationships were seen in the HCs. Fatiguability and the extent of life satisfaction were only related to depression (BDI p < 0.001) and not associated with any MRI-based outcomes. Most relationships between structural pathology and PROs were mediated by BDI scores (p < 0.001). In the pwMS group, there were no significant differences in any MRI-based brain volumes between the levels of reported life satisfaction. Conclusion PRO measures of lower extremity limitations were associated with DGM structures and DGM-specific nuclei. These findings promote the relevance of measuring DGM structures as measures directly related to subjective well-being and walking limitations. Depression is a significant mediator of PROs and in particular of life satisfaction.

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Section: Discussionmentioning

confidence: 99%

Neuroimaging Correlates of Patient-Reported Outcomes in Multiple Sclerosis

Jakimovski¹,

Wicks²,

Bergsland³

et al. 2023

DNND

Self Cite

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“…This finding in line with [66] who mentioned that lack of understanding of MS disease, as well as the uncertainty of MS symptoms, all this challenges makes the MS patient difficult to response to treatments, in which an effective communication has a critical role in improving; acceptance of the disease, patients' compliance with chronic treatments and patients' quality of life. [67] added that the demanding need of care in MS patients demonstrates social, psychological, and physical impact not only patients but also their families or caregivers.…”

Section: Discussionmentioning

confidence: 99%

Fatigue and Self-management among Multiple Sclerosis Patients

Shawli¹,

Abdulmutalib²,

Nagshabandi³

2019

AJNR

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Fatigue is considered as the most revealed symptoms in multiple sclerosis patients, reported by 88% of patients and has significant impact on all stages of life such as altering in daily living activity or psychosocial/mental functions. The pathogenesis of fatigue remain poorly understood and how its impact on self-management. The aim of study was to assess fatigue and self management among multiple sclerosis patients. A quantitative descriptive correlational design was used in this study. The study was conducted at both King Abdulaziz University Hospital and King Fahad Armed Forces Hospitals in Jeddah City from January till March 2018, data collected from outpatients' clinic and Inpatients' medical-wards. A convenience sample of 50 Multiple Sclerosis patients. Data was collected through the main one tool, it consists of three parts; Part I, Socio-demographic and clinical data constructed by the researchers. Part П, Modified Fatigue Impact scale; to assess the Impact of fatigue on physical, cognitive, and psychosocial functioning in patient with Multiple Sclerosis.. Part ПІ, Multiple Sclerosis Self Management Scale Revised; to provide a multidimensional and psychometrically assessment of self-management knowledge and behavior among Multiple Sclerosis patients. The study results showed there was a statistically significant negative correlations between fatigue subscales and overall self-management among Multiple Sclerosis patients with p-value (.019). Also, there was a statistically significant negative correlations between self-management factor scales and overall fatigue among Multiple Sclerosis patients with p-value (.019). It was concluded that there was a negative correlations between overall fatigue and overall self-management among Multiple Sclerosis patients, whenever fatigue severity increases, self-management decreases. It was a recommendation to encourage governmental policy and other decision makers in the Saudi community to develop periodically structure health education training program regarding self-management in MS and provide appropriate environments or facilities to conduct such programs, where nurses play a key role through health education and cooperate with other health care system.

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