Fatigue and pain in human jaw muscles during a sustained, low-intensity clenching task

Svensson, Peter; Burgaard, A.; Schlosser, Stephan

doi:10.1016/s0003-9969(01)00028-0

Cited by 88 publications

(87 citation statements)

References 14 publications

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“…Mean values of the EMG relative amplitude continuously increased throughout the submaximal clenching tasks. This agrees with previous findings obtained from the same muscles (Svensson et al, 2001) and has been explained through facilitated motor unit recruitment (Moritani et al, 1986), increase in the degree of synchronization between motor units (Krogh-Lund and Jorgensen, 1991), and decrease of action potential conduction velocity along the muscle fibers (Lindstrom et al, 1977).…”

Section: Discussionsupporting

confidence: 93%

“…The hyperactivity hypothesis has been tested by attempting to overload the masticatory muscles under experimental controlled conditions (Bakke et al, 1996;Clark et al, 1984;Clark and Carter, 1985;Clark et al, 1989;Farella et al, 2001;Glaros and Burton, 2004;Jow and Clark, 1989;Svensson and Arendt-Nielsen, 1996;Svensson et al, 2001;Christensen, 1989). The findings of these studies showed that moderate to high (i.e.…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, there is evidence that prolonged static contractions at lower contraction levels (i.e. < 25% MVC) may significantly reduce bite force and jaw opening capacity (Svensson et al, 2001), and lead to pain and tenderness in the masticatory muscles (Glaros et al, 2000;Glaros and Burton, 2004), which are the most common signs and symptoms of temporomandibular disorders (TMD).…”

Section: Introductionmentioning

confidence: 99%

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Synergist coactivation and substitution pattern of the human masseter and temporalis muscles during sustained static contractions

Farella

Palumbo

Milani

et al. 2009

Clinical Neurophysiology

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Synergist coactivation and substitution pattern of the human masseter and temporalis muscles during sustained static contractions

Farella

Palumbo

Milani

et al. 2009

Clinical Neurophysiology

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“…2,8,11,30 In human subjects with experimental muscle pain, there is a decrease in muscle peak force and endurance in painful and in synergistic muscles. 7 A low-intensity, 60-minuteduration tooth clenching task produces fatigue and pain during the task, 49 suggesting fatigue produces pain. However, after the tooth clenching task, subjects report continue to report pain and headaches.…”

mentioning

confidence: 99%

Muscle Fatigue Increases the Probability of Developing Hyperalgesia in Mice

Yokoyama

Lisi

Moore

et al. 2007

The Journal of Pain

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Chronic muscle pain is a major clinical problem that is often associated with fatigue. Conversely, chronic fatigue conditions are commonly associated with muscle pain. We tested the hypothesis that muscle fatigue enhances hyperalgesia associated with injection of acidic saline into muscle. We evaluated mechanical sensitivity of the paw (von Frey) in mice after 2 intramuscular injections of saline (20 µL; pH 4, pH 5, pH 6, pH 7.2) in a fatigue and a control group. To induce fatigue, mice were run for 2 h/day for 2 days prior to the first injection and 2 h/day for 2 days prior to the second injection. Muscle lactate, pCO 2 , pO 2 , creatinine kinase, phosphate, and histology were examined after the fatigue task and compared to a control group. Grip force was significantly decreased after 2 h of running indicating fatigue. The fatigue task did not induce muscle damage as there was no difference in muscle lactate, pCO 2 , pO 2 , creatinine kinase, phosphate, or histology. The fatigue task altered the dose-response relationship to intramuscular acidic saline injections. Mechanical hyperalgesia was observed in both fatigue and control groups after intramuscular injection of pH 4.0, but only the fatigue group after injection of pH 5. Neither the fatigue nor the control group developed hyperalgesia in response to intramuscular injection of pH 6 or pH 7.2. In conclusion, fatigue modified the susceptibility of mice to acid injection of pH 5.0 to result in mechanical hyperalgesia after 2 injections of pH 5.0. The fatigue task did not produce measurable changes in the muscle tissue suggesting a central mechanism mediating the enhancement of hyperalgesia.Perspective-These data therefore show that muscle fatigue can enhance the likelihood that one develops pain to a mild insult. Clinically, this could relate to the development of pain from such conditions as repetitive strain injury, and may relate to the interrelationship between chronic pain and fatigue. KeywordsFatigue; exercise; acid; protons; low-pH saline Pain arising from musculoskeletal disorders is a major clinical problem globally, 58 and fibromyalgia affects 2% of population in the United States. 57 As high as 76% of people with chronic widespread musculoskeletal pain conditions, such as fibromyalgia and arthritis, also report fatigue. 26 Conversely, as high as 94% of people with chronic fatigue syndrome report musculoskeletal pain and approximately half of the population has chronic widespread musculoskeletal pain. 56,60 Pain is increased during and after exercise in people with fibromyalgia and chronic fatigue syndrome. 20,48,54,55 Similarly, muscle fatigue is increased in people with chronic fatigue syndrome. 3,10,23 To assess mechanisms of chronic widespread pain, we developed an animal model that mimics the clinical symptoms. Two injections of acidic saline (pH 4.0), 5 days apart, into 1 muscle results in bilateral long-lasting hyperalgesia of the paw, 41 muscle,59 and the viscera28 without muscle tissue damage.41 The intramuscular pH decreases to a p...

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“…Given that the average total time of functional tooth contact during chewing or swallowing is only 17.5 min/day [29], it is believed that continuous nonfunctional tooth contact causes overload of the TMJ and masticatory muscles. In fact, it has been shown that the association between clenching and muscle pain is due either to damaged muscle fibers or decreased blood supply to these fibers because the perfusion of the masseter was significantly lessened [30][31][32][33][34][35] during clenching. Therefore, TCH also affected the onset, persistence, and aggravation of TMD.…”

Section: Discussionmentioning

confidence: 99%

Magnitude of Bite Force that is Interpreted as Clenching in Patients with Temporomandibular Disorders: A Pilot Study

Nishiyama

Otomo²,

Tsukagoshi³

et al. 2014

Dentistry

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Fatigue and pain in human jaw muscles during a sustained, low-intensity clenching task

Cited by 88 publications

References 14 publications

Synergist coactivation and substitution pattern of the human masseter and temporalis muscles during sustained static contractions

Synergist coactivation and substitution pattern of the human masseter and temporalis muscles during sustained static contractions

Muscle Fatigue Increases the Probability of Developing Hyperalgesia in Mice

Magnitude of Bite Force that is Interpreted as Clenching in Patients with Temporomandibular Disorders: A Pilot Study

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