Fatigue and progression of corpus callosum atrophy in multiple sclerosis

Abstract

Fatigue is one of the most disabling symptoms in multiple sclerosis (MS) patients. There is no or only weak correlation between conventional magnetic resonance imaging (MRI) parameters and level of fatigue.

Classifying minimally disabled multiple sclerosis patients from resting state functional connectivity

“…This finding is compatible with the well-known preferential affection of the corpus callosum in MS (GeanMarton et al, 1991;Evangelou et al, 2000;Mesaros et al, 2009;Rocca et al, 2010;Yaldizli et al, 2011) and presumably reflects in part the concentration of all inter-hemispheric connections at a relatively small circumscribed location in the brain. Our results therefore add to previous studies reporting a decreased inter-hemispheric functional connectivity at rest in MS patients (Cover et al, 2006).…”

Progress in multiple sclerosis research in the last year

“…Yaldizli et al [2] investigated the relationship between progression of corpus callosum (CC) atrophy at magnetic resonance imaging (MRI) and fatigue in 70 patients with relapsing-remitting (RR) MS over a 4.8 year follow-up study. Patients with fatigue (representing 40 % of the cohort) had higher expanded disability status scale (EDSS) scores, as well as a more pronounced CC atrophy [2].…”

“…Yaldizli et al [2] investigated the relationship between progression of corpus callosum (CC) atrophy at magnetic resonance imaging (MRI) and fatigue in 70 patients with relapsing-remitting (RR) MS over a 4.8 year follow-up study. Patients with fatigue (representing 40 % of the cohort) had higher expanded disability status scale (EDSS) scores, as well as a more pronounced CC atrophy [2]. Morgante et al [3] tested the hypothesis that central fatigue in MS might be correlated with a dysfunction in the cortical areas upstream of the pyramidal tract involved in motor planning and preparation.…”

Neuroimaging of corpus callosum in central nervous system demyelinating disorders

“…[6] MS plaques mostly occur in the body of the CC, as suggested by some studies. [21][22][23][24][25] Diffuse atrophy of the CC is believed to be a part of general cerebral atrophy in long standing cases or it can be caused by wallerian degeneration and loss of axons within the CC. [26] According to the study by Chen et al, [6] MRI findings can have a big role in discrimination between MS and other demyelinating disorders, in particular MS and Neuromyelitis optica.…”