Fatigue, anxiety and depression in patients with prediabetes: a controlled cross-sectional study

Topaloğlu, Ulaş Serkan; Erol, Kemal

doi:10.1007/s13340-022-00583-0

Cited by 8 publications

(7 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PD has been linked to risk of depression in various studies[ 106 , 107 ], likely through insulin resistance. Insulin resistance in the brain induces mitochondrial and dopaminergic dysfunction leading to anxiety and depressive-like behaviors[ 108 ].…”

Section: Is Ckd the Only Concern Of Pd?mentioning

confidence: 99%

“…Development of diabetes and CKD are not the only worries. Other complications of PD including cardiovascular disease[ 7 , 72 , 73 ], stroke[ 76 , 81 - 84 ], neuropathies[ 85 - 88 , 90 , 122 ], retinopathy[ 91 - 95 ], dementia[ 96 - 101 , 103 - 105 ], depression[ 106 - 116 ], cancers[ 117 - 119 ], non-alcoholic fatty liver disease[ 124 - 128 ] and increased all-cause mortality[ 46 , 131 , 132 ] are well established in the general population. Therefore, it is the responsibility of the transplant team that there should be no maleficence and every effort should be taken to follow the ethical principle “first do no harm”[ 201 ].…”

Section: What Should Be the Way Forward?mentioning

confidence: 99%

See 1 more Smart Citation

Pros and cons of live kidney donation in prediabetics: A critical review and way forward

Khalil,

Sadagah,

Tan

et al. 2024

World J Transplant

View full text Add to dashboard Cite

There is shortage of organs, including kidneys, worldwide. Along with deceased kidney transplantation, there is a significant rise in live kidney donation. The prevalence of prediabetes (PD), including impaired fasting glucose and impaired glucose tolerance, is on the rise across the globe. Transplant teams frequently come across prediabetic kidney donors for evaluation. Prediabetics are at risk of diabetes, chronic kidney disease, cardiovascular events, stroke, neuropathy, retinopathy, dementia, depression and nonalcoholic liver disease along with increased risk of all-cause mortality. Unfortunately, most of the studies done in prediabetic kidney donors are retrospective in nature and have a short follow up period. There is lack of prospective long-term studies to know about the real risk of complications after donation. Furthermore, there are variations in recommendations from various guidelines across the globe for donations in prediabetics, leading to more confusion among clinicians. This increases the responsibility of transplant teams to take appropriate decisions in the best interest of both donors and recipients. This review focuses on pathophysiological changes of PD in kidneys, potential complications of PD, other risk factors for development of type 2 diabetes, a review of guidelines for kidney donation, the potential role of diabetes risk score and calculator in kidney donors and the way forward for the evaluation and selection of prediabetic kidney donors.

show abstract

Section: Is Ckd the Only Concern Of Pd?mentioning

confidence: 99%

Section: What Should Be the Way Forward?mentioning

confidence: 99%

Pros and cons of live kidney donation in prediabetics: A critical review and way forward

Khalil,

Sadagah,

Tan

et al. 2024

World J Transplant

View full text Add to dashboard Cite

show abstract

“…Of these 30 studies, 13 were excluded due to the absence of reported BMD (n = 11), the absence of BMD results presented by mean and SD or SE (n = 1) or no comparative data between prediabetes and control groups (n = 1). Finally, 17 studies were included [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] (Figure 1).…”

Section: Literature Searchmentioning

confidence: 99%

The association between prediabetes and bone mineral density: A meta‐analysis

Pan

Hong

Zhang

et al. 2023

Diabetes Metabolism Res

View full text Add to dashboard Cite

BackgroundPrediabetes is an intermediate metabolic state between euglycaemia and diabetes, including three different definitions: impaired fasting glucose, impaired glucose tolerance, and mildly elevated glycated haemoglobin (HbA1c) (range 5.7%–6.4%). The effect of prediabetes on bone mineral density (BMD) has not been established. Therefore, we performed a meta‐analysis to evaluate the association between prediabetes and BMD.MethodsWe retrieved studies related to prediabetes and BMD from PubMed, Web of Science, and Embase databases from January 1990 to December 2022. All data were analysed using the random effects model. Statistical heterogeneity was tested by I2. Subgroup analysis was performed after each study‐level variable was pre‐defined by meta‐regression.ResultsA total of 17 studies were included involving 45,788 patients. We detected a significant overall association of prediabetes with increased spine BMD (weighted mean difference [WMD] = 0.01, 95% CI [0.00, 0.02], p = 0.005; I2 = 62%), femur neck (FN) BMD (WMD = 0.01, 95% CI [0.00, 0.01], p < 0.001; I2 = 19%), and femur total (FT) BMD (WMD = 0.02, 95% CI [0.01, 0.03], p < 0.001; I2 = 51%). Several variables leading to heterogeneity were defined by meta‐regression, including age, sex, region, study type, dual‐energy X‐ray absorptiometry scanner manufacturer, and prediabetes definition. Subgroup analyses indicated that the association of prediabetes with increased BMD was stronger in men, Asians, and older adults over 60 years of age.ConclusionsCurrent evidence shows that prediabetes is strongly associated with increased BMD of the spine, FN, and FT. The association was stronger among males, Asians, and older adults over 60 years of age.

show abstract

“…However, given that shared pathophysiological pathways may exist linking depressive/anxiety symptoms and prediabetes to type 2 diabetes, 5 it remains unclear whether depressive or anxiety symptoms and prediabetes are independent or interconnected risk factors for type 2 diabetes as more evidence is needed. Furthermore, prediabetes has been associated with an increased mental health disease burden compared to normoglycemia, 12 and thus examining these interactions longitudinally in a large sample could provide us with a clearer understanding of their interplay.…”

Section: Introductionmentioning

confidence: 99%

Prediabetes and the risk of type 2 diabetes: Investigating the roles of depressive and anxiety symptoms in the Lifelines cohort study

et al. 2023

View full text Add to dashboard Cite

Aims Depression and anxiety may increase the risk of progressing from prediabetes to type 2 diabetes. The present study examined the interactions between prediabetes status and elevated depressive and anxiety symptoms with the risk of type 2 diabetes. Methods Participants (N = 72,428) were adults aged 40 years and above without diabetes at baseline from the Lifelines Cohort Study (58% female; mean age = 51.4 years). The Mini‐International Neuropsychiatric Interview screened for elevated symptoms of major depressive disorder and generalized anxiety disorder. Glycated haemoglobin A1c (HbA1c) levels determined prediabetes status at baseline (2007–2013), and HbA1c and self‐reported diabetes diagnoses determined diabetes status at follow‐up (2014–2017). Groups were formed for elevated depressive and anxiety symptoms, respectively, and prediabetes status at baseline (elevated depressive/anxiety symptoms with prediabetes, elevated depressive/anxiety symptoms alone, and prediabetes alone), and compared to a reference group (no prediabetes or anxiety/depression) on the likelihood of developing diabetes during the follow‐up period. Results N = 1300 (1.8%) participants developed diabetes. While prediabetes alone was associated with incident diabetes (OR = 5.94; 95% CI = 5.10–6.90, p < 0.001), the group with combined prediabetes and depressive symptoms had the highest likelihood of developing diabetes over follow‐up (OR = 8.29; 95% CI = 5.58–12.32, p < 0.001). Similar results were found for prediabetes and anxiety symptoms (OR = 6.57; 95% CI = 4.62–9.33, p < 0.001), compared to prediabetes alone (OR = 6.09; 95% CI = 5.23–7.11, p < 0.001), though with a smaller effect. The interaction between depressive symptoms and prediabetes was synergistic in age‐and‐sex adjusted analyses. Conclusions Individuals with elevated depressive, and to some extent anxiety, symptoms in combination with prediabetes may represent a high‐risk subgroup for type 2 diabetes.

show abstract

Fatigue, anxiety and depression in patients with prediabetes: a controlled cross-sectional study

Cited by 8 publications

References 25 publications

Pros and cons of live kidney donation in prediabetics: A critical review and way forward

Pros and cons of live kidney donation in prediabetics: A critical review and way forward

The association between prediabetes and bone mineral density: A meta‐analysis

Prediabetes and the risk of type 2 diabetes: Investigating the roles of depressive and anxiety symptoms in the Lifelines cohort study

Contact Info

Product

Resources

About