Fatigue behaviour of load-bearing polymeric bone scaffolds: A review

Bakhtiari, Hamed; Nouri, Alireza; Khakbiz, Mehrdad; Tolouei-Rad, Majid

doi:10.1016/j.actbio.2023.09.048

Cited by 15 publications

(1 citation statement)

References 146 publications

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“…However, the conditions required for bone defects in vivo are different. Ions in extracellular matrix are necessary, and more importantly, high-strength scaffolds provide support for tissue repair. , Scaffolds with different mechanical strength can induce cell-specific differentiation . In both in vivo and in vitro experiments, it is noted that, despite the P3 scaffold displaying extremely poor mechanical properties, its osteogenic effect is comparable to that of the P2 scaffold.…”

Section: Discussionmentioning

confidence: 99%

Chestnut-Inspired Hollow Hydroxyapatite 3D Printing Scaffolds Accelerate Bone Regeneration by Recruiting Calcium Ions and Regulating Inflammation

Wei,

Zhou,

Xiong

et al. 2024

ACS Appl. Mater. Interfaces

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This study aims to overcome the drawbacks associated with hydroxyapatite (HAP) dense structures after sintering, which often result in undesirable features such as large grain size, reduced porosity, high crystallinity, and low specific surface area. These characteristics hinder osseointegration and limit the clinical applicability of the material. To address these issues, a new method involving the preparation of hollow hydroxyapatite (hHAP) microspheres has been proposed. These microspheres exhibit distinctive traits including weak crystallization, high specific surface area, and increased porosity. The weak crystallization aligns more closely with early mineralization products found in the human body and animals. Moreover, the microspheres' high specific surface area and porosity offer advantages for protein loading and facilitating osteoblast attachment. This innovative approach not only mitigates the limitations of conventional HAP structures but also holds the potential for improving the effectiveness of hydroxyapatite in biomedical applications, particularly in enhancing osseointegration. Three-dimensional printed hHAP/chitosan (CS) scaffolds with different hHAP concentration gradients were manufactured, and the physical and biological properties of each group were systematically evaluated. In vitro and in vivo experiments show that the hHAP/CS scaffold has excellent performance in bone remodeling. Furthermore, in-scaffold components, hHAP and CS were cocultured with bone marrow mesenchymal stem cells to explore the regulatory role of hHAP and CS in the process of bone healing and to reveal the cell-level specific regulatory network activated by hHAP. Enrichment analysis showed that hHAP can promote bone regeneration and reconstruction by recruiting calcium ions and regulating inflammatory reactions.

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Section: Discussionmentioning

confidence: 99%

Chestnut-Inspired Hollow Hydroxyapatite 3D Printing Scaffolds Accelerate Bone Regeneration by Recruiting Calcium Ions and Regulating Inflammation

Wei,

Zhou,

Xiong

et al. 2024

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

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Recent Advances in 3D Printing of Smart Scaffolds for Bone Tissue Engineering and Regeneration

Yuan,

Zhu,

Yang

et al. 2024

Advanced Materials

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The repair and functional reconstruction of bone defects resulting from severe trauma, surgical resection, degenerative disease, and congenital malformation pose significant clinical challenges. Bone tissue engineering (BTE) holds immense potential in treating these severe bone defects, without incurring prevalent complications associated with conventional autologous or allogeneic bone grafts. 3D printing technology enables control over architectural structures at multiple length scales and has been extensively employed to process biomimetic scaffolds for BTE. In contrast to inert and functional bone grafts, next‐generation smart scaffolds possess a remarkable ability to mimic the dynamic nature of native extracellular matrix (ECM), thereby facilitating bone repair and regeneration. Additionally, they can generate tailored and controllable therapeutic effects, such as antibacterial or antitumor properties, in response to exogenous and/or endogenous stimuli. This review provides a comprehensive assessment of the progress of 3D‐printed smart scaffolds for BTE applications. It begins with an introduction to bone physiology, followed by an overview of 3D printing technologies utilized for smart scaffolds. Notable advances in various stimuli‐responsive strategies, therapeutic efficacy, and applications of 3D‐printed smart scaffolds are discussed. Finally, the review highlights the existing challenges in the development and clinical implementation of smart scaffolds, as well as emerging technologies in this field.

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Silk Nanofibers/Carbon Nanotube Conductive Aerogel

Feng,

Wang,

Dai

et al. 2024

Macromol. Rapid Commun.

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Natural silk nanofibers (SNF) are attractive conductive substrates due to their high aspect ratio, outstanding mechanical strength, excellent biocompatibility, and controllable degradability. However, the inherently non‐conductivity severely restricts the potential sensor application of SNF‐based aerogels. In this work, the conductive nanofibrous aerogels with low‐density achieved through freeze–drying by dispersing carbon nanotubes (CNT) into SNF suspension. The addition of CNT significantly increases the conductivity with improved mechanical properties of composite aerogels. SEM results reveal that the distinct hierarchical structure comprising micropores and nanofibrous networks within the pores is formed when CNT content reached 30%. Furthermore, increased cell viability suggested the excellent biocompatibility of SNF‐CNT‐based conductive aerogel for tissue‐engineering applications. Subsequently, the elastic water‐borne polyurethane (WPU) is incorporated to SNF‐CNT system to construct aerogel with good sensing properties. The introduction of WPU demonstrates enhanced compressive performances and an exceptionally high elastic recovery ratio of 99.8%, thereby exhibiting a stable and lossless strain‐sensing signal output at 5% strain. This study provides a feasible choice and strategy for exploring the potential application of SNF in functional aerogels.

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Fatigue behaviour of load-bearing polymeric bone scaffolds: A review

Cited by 15 publications

References 146 publications

Chestnut-Inspired Hollow Hydroxyapatite 3D Printing Scaffolds Accelerate Bone Regeneration by Recruiting Calcium Ions and Regulating Inflammation

Chestnut-Inspired Hollow Hydroxyapatite 3D Printing Scaffolds Accelerate Bone Regeneration by Recruiting Calcium Ions and Regulating Inflammation

Recent Advances in 3D Printing of Smart Scaffolds for Bone Tissue Engineering and Regeneration

Silk Nanofibers/Carbon Nanotube Conductive Aerogel

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