Tailor-made materials used for advanced applications are nowadays of great research interest in various industrial and technological fields, ranging from aerospace and automotive applications to consumer goods and biomedical components. In the present research, Inconel 718 superalloy specimens were fabricated by the selective laser melting (SLM) technique. Structural characterization of the 3D-printed samples showed that they consisted of γ solid solution along with spherical carbide particles. To explore the applicability of these materials in abrasive tribological applications, reciprocating sliding tests were performed under dry conditions versus an Al2O3 counter-body. A 3D representation (triboscopy) of the tangential force during each sliding cycle was carried out in order to obtain better insight on the evolution of friction and to visualize localized tribological phenomena. Quantification of wear was performed with confocal microscopy and the wear mechanisms were analyzed with SEM and EDS techniques. Furthermore, the effect of surface finishing (as-printed and polished) on friction and wear were also investigated, and a comparison with other industrial materials is also included to evaluate the applicability of these alloys. The results indicated that surface finishing had an effect on friction during the run-in stage, whereas in steady-state conditions, no significant differences were observed between the as-printed and polished specimens. In all cases, the main wear mechanisms observed were a mixture of two-body and three-body abrasion, along with oxidative wear (indicated by the formation of an oxide-based tribo-layer).