Fatigue does not correlate with the degree of hepatitis or the presence of autoimmune disorders in chronic hepatitis C infection

Goh, J; Coughlan, Barbara; Quinn, Jeffrey; O'Keane, J C; Crowe, J.

doi:10.1097/00042737-199908000-00004

Cited by 107 publications

(85 citation statements)

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“…To date, the causal factors of a reduced HRQoL in such patients are poorly understood, even though psychological and social impact of Hepatitis C Virus (HCV) infection diagnosis, as well as HCV itself and interferon treatment, seem to play a crucial role (17)(18)(19). On the other hand, neither the stage of the liver disease nor the viral load nor the presence of extrahepatic manifestations seem to influence the HRQoL (20).…”

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confidence: 99%

An Italian Study on Health-Related Quality of Life and Fatigue in Patients with Chronic Fatigue Syndrome and Patients with Chronic HCV Virus Infection: Similarities and Differences

Racciatti

Gorgoretti

Sepede

et al. 2011

Int J Immunopathol Pharmacol

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Severe fatigue and a significantly reduced health-related quality of life (HRQoL) have been described in patients with chronic fatigue syndrome (CFS) in comparison with patients affected by chronic hepatitis C (CHC) and other chronic medical conditions. We examined 39 CFS and 49 CHC patients to explore whether fatigue and a poor HRQoL represent a greater medical and social problem in CFS than in CHe. The severity of fatigue and the HRQoL were assessed using the Fatigue Impact Scale (FIS) and the Health Status Questionnaire Short Form-36 (SF-36), respectively. The statistical analysis showed both a higher score offatigue and a lower HRQoL in CFS than in CHC patients. Furthermore, in CUC patients the FIS evaluation showed a significantly reduced score of the psychosocial domain in comparison with the other domains. Multivariate linear regression analysis revealed female gender as the most important positive variable in chronic hepatitis C patients for total score of FIS. In conclusion, CFS was associated with a severe and disabling fatigue and an impaired HRQOL. In particular, both fatigue and all aspects of HRQOL perceived by CFS patients were significantly impaired compared to CHC patients. Consequently, management of fatigue should be considered a priority in order to improve HRQOL in CFS patients. In CHC patients the impact of fatigue on HRQoL was less significant than in CFS patients, even though the FIS evaluation showed a significant impairment of the psychosocial domain.

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confidence: 99%

An Italian Study on Health-Related Quality of Life and Fatigue in Patients with Chronic Fatigue Syndrome and Patients with Chronic HCV Virus Infection: Similarities and Differences

Racciatti

Gorgoretti

Sepede

et al. 2011

Int J Immunopathol Pharmacol

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“…4 These findings are in agreement with the clinical observation that patients with chronic HCV infection frequently report fatigue, lassitude, depression, and a perceived inability to function effectively. 5,6 The etiology of these symptoms is unknown. The symptoms do not appear to be associated with the degree of hepatitis, the presence of autoimmune disorders 5 or cirrhosis, 3 a history of intravenous drug usage (IVDU), 3 or the level of circulating cytokines.…”

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confidence: 99%

“…5,6 The etiology of these symptoms is unknown. The symptoms do not appear to be associated with the degree of hepatitis, the presence of autoimmune disorders 5 or cirrhosis, 3 a history of intravenous drug usage (IVDU), 3 or the level of circulating cytokines. 7 We have previously reported cerebral metabolite abnormalities in patients with histologically proven mild HCV infection using proton magnetic resonance spectroscopy ( 1 H MRS).…”

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confidence: 99%

Hepatitis C and cognitive impairment in a cohort of patients with mild liver disease

et al. 2002

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Patients with chronic hepatitis C virus (HCV) infection frequently report fatigue, lassitude, depression, and a perceived inability to function effectively. Several studies have shown that patients exhibit low quality-of-life scores that are independent of disease severity. We therefore considered whether HCV infection has a direct effect on the central nervous system, resulting in cognitive and cerebral metabolite abnormalities. Twenty-seven viremic patients with biopsy-proven mild hepatitis due to HCV and 16 patients with cleared HCV were tested with a computer-based cognitive assessment battery and also completed depression, fatigue, and quality-of-life questionnaires. The HCV-infected patients were impaired on more cognitive tasks than the HCV-cleared group ( C hronic hepatitis C (HCV) infection is estimated to affect 170 million people worldwide 1 and constitutes a major public health problem. It causes a fluctuating chronic hepatitis that may progress to cirrhosis and hepatocellular carcinoma. Attempts to understand the natural history of this infection have largely focused on the viral and host factors that predict progression of liver pathology from necroinflammation and fibrosis to cirrhosis and hepatocellular carcinoma. Consequently, the decision to treat patients is normally based on an assessment of these factors, including staging of disease with a liver biopsy, 2 rather than on particular symptoms. There is, however, emerging literature suggesting that, even in the absence of clinically significant liver disease, chronic HCV infection causes a substantial reduction in quality of life 3 that improves following successful antiviral treatment. 4 These findings are in agreement with the clinical observation that patients with chronic HCV infection frequently report fatigue, lassitude, depression, and a perceived inability to function effectively. 5,6 The etiology of these symptoms is unknown. The symptoms do not appear to be associated with the degree of hepatitis, the presence of autoimmune disorders 5 or cirrhosis, 3 a history of intravenous drug usage (IVDU), 3 or the level of circulating cytokines. 7 We have previously reported cerebral metabolite abnormalities in patients with histologically proven mild HCV infection using proton magnetic resonance spectroscopy ( 1 H MRS). 8 These abnormalities are similar to the 1 H MRS changes reported in cerebral human immunodeficiency virus (HIV) infection in both cognitively impaired 9,10 and asymptomatic individuals. 11 In this study, we address the hypothesis that HCV infection can result in cerebral dysfunction, which may underlie both the neuropsychological symptoms and the 1 H MRS abnormalities described. We used a cognitive assessment battery to determine whether cognitive impairment exists in patients with histologically defined mild chronic HCV infection and 1 H MRS to determine whether cerebral metabolite abnormalities are associated with impaired cognitive function.

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“…Update on Hepatitis CChronic fatigue (often called "brain fog") is perceived as a sensation of physical and mental exhaustion, and when severe, it is accompanied by deicits of atention tasks, anomia, and word-inding diiculties, in the absence of verbal memory or cognitive ability impairments [6].…”

Section: Neuropsychological Manifestationsmentioning

confidence: 99%

Neuropathological and Neuropsychiatric Determinants in HCV- Infected Patients

Vojnović¹

2017

Update on Hepatitis C

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Chronic hepatitis C virus (HCV) infection is a growing global health problem. HCV is a leading cause of chronic hepatitis, cirrhosis, and hepatocellular carcinoma (HCC) and is associated with more than 30 extrahepatic manifestations (EHMs). Although cryoglobulinemia is the main pathological cause of neurologic EHMs, HCV viral replication in the brain itself must also be taken into consideration. The most signiicant neurological manifestations of HCV chronic infection are stroke, leukoencephalopathy, encephalomyelitis/myelitis, and peripheral neuropathy. The most signiicant neuropsychological manifestations of HCV infection are fatigue, depression, anxiety, and cognitive dysfunction. Antiviral HCV treatment should be the irst-line treatment for managing mild-tomoderate vascular and neurologic symptoms; most of EHMs improve or even resolve if antiviral treatment starts on time.

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Fatigue does not correlate with the degree of hepatitis or the presence of autoimmune disorders in chronic hepatitis C infection

Cited by 107 publications

References 0 publications

An Italian Study on Health-Related Quality of Life and Fatigue in Patients with Chronic Fatigue Syndrome and Patients with Chronic HCV Virus Infection: Similarities and Differences

An Italian Study on Health-Related Quality of Life and Fatigue in Patients with Chronic Fatigue Syndrome and Patients with Chronic HCV Virus Infection: Similarities and Differences

Hepatitis C and cognitive impairment in a cohort of patients with mild liver disease

Neuropathological and Neuropsychiatric Determinants in HCV- Infected Patients

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