Fatigue in colorectal cancer patients: prevalence and associated factors

Mota, Dálete Delalibera Corrêa de Faria; Pimenta, Cibele Andrucioli de Mattos; Caponero, Ricardo

doi:10.1590/s0104-11692012000300010

Cited by 41 publications

(32 citation statements)

References 25 publications

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“…An alteration of muscle fiber innervation contributes to explaining the functional deficit observed in cachectic muscles. It is well known that cachectic mice and men have lower muscle performance and a high prevalence of fatigue [53,54]. Similar functional deficits are reported in sarcopenia: focal denervation accounting for local switches to a slow fiber phenotype, severe atrophy of certain muscle fibers, and diminished muscle force [55].…”

Section: Discussionmentioning

confidence: 76%

Displaced Myonuclei in Cancer Cachexia Suggest Altered Innervation

Daou

Hassani

Matos

et al. 2020

IJMS

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An idiopathic myopathy characterized by central nuclei in muscle fibers, a hallmark of muscle regeneration, has been observed in cancer patients. In cancer cachexia skeletal muscle is incapable of regeneration, consequently, this observation remains unaccounted for. In C26-tumor bearing, cachectic mice, we observed muscle fibers with central nuclei in the absence of molecular markers of bona fide regeneration. These clustered, non-peripheral nuclei were present in NCAM-expressing muscle fibers. Since NCAM expression is upregulated in denervated myofibers, we searched for additional makers of denervation, including AchRs, MUSK, and HDAC. This last one being also consistently upregulated in cachectic muscles, correlated with an increase of central myonuclei. This held true in the musculature of patients suffering from gastrointestinal cancer, where a progressive increase in the number of central myonuclei was observed in weight stable and in cachectic patients, compared to healthy subjects. Based on all of the above, the presence of central myonuclei in cancer patients and animal models of cachexia is consistent with motor neuron loss or NMJ perturbation and could underlie a previously neglected phenomenon of denervation, rather than representing myofiber damage and regeneration in cachexia. Similarly to aging, denervation-dependent myofiber atrophy could contribute to muscle wasting in cancer cachexia.

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Section: Discussionmentioning

confidence: 76%

Displaced Myonuclei in Cancer Cachexia Suggest Altered Innervation

Daou

Hassani

Matos

et al. 2020

IJMS

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“…Sleep problems are prevalent in cancer patients [5], nearly two-thirds of patients reported symptoms including long latency periods before falling or staying asleep, frequent nocturnal awakenings, and impaired seep quality [6]. Higher levels of sleep problems predicted for more fatigue, depression and poorer performance status [7].…”

Section: Introductionmentioning

confidence: 99%

Incidence of sleep problems and their mediating role on depression and anxious preoccupation in patients with resected, non-advanced cancer: data from NEOcoping study

et al. 2019

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Background Our study analyzes the incidence of sleep problems and their mediating role on depression and anxious preoccupation in patients with resected, non-advanced cancer. Methods A multi-institutional, prospective, observational study was conducted with 750 participants of 14 hospitals in Spain. Participants' socio-demographic and clinical characteristics were collected using a standardized self-report form and using EORTC QoL-QLQ-C30, BSI, Mini-MAC questionnaires. Results In women, sleep problems, depression and anxious preoccupation were observed in 65, 41 and 21%, respectively. In men, sleep problems, depression and anxious preoccupation were reported in 51, 29 and 61%, respectively. More sleep problems, depression and anxious preoccupation were found among women than males. Depression was a significant predictor of anxious preoccupation. In males, sleep problems partially mediated this association. This was not confirmed in women. Conclusion Our findings point toward the importance of developing interventions that decrease depression and sleep problems in cancer.

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“…Many factors exacerbate the symptoms of fatigue in patients. On the basis of the severity of the disease, fatigue-related factors can be associated with very broad aspects such as the socioeconomic factors (gender, level of education, having a permanent job) or the clinical characteristics of the disease (duration of diagnosis, diet therapy, the physical condition of the patient, and the type of cancer) and each can affect the level of fatigue in the patient (14). Although the possible roles of some variables such as the stage of disease, the type of cancer, and anaemia have been reported in cancerrelated fatigue, there is insufficient evidence yet.…”

Section: Introductionmentioning

confidence: 99%

The Assessment of Fatigue and its Related Factors in Patients with Cancer

Rizi

Khanghah

Adib

et al. 2017

J Holist Nurs Midwifery

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Introduction: Cancer is a major health issue in Iran and in the rest of the world. Fatigue is one of the most complex and the most prevalent cancer-related problems that can affect various aspects of life for cancer patients. It can cause numerous problems. Objective: The aim of this study was to determine the level of fatigue and its associated factors in patients with cancer. Materials and Methods: In this descriptive-analytical study, 90 cancer patients referred to the oncology department in one of the teaching hospitals were assessed. The data collection tool was a questionnaire based on demographic information and the fatigue severity scale (FSS). This questionnaire consisted of nine questions with a numeric scale for answers ranging from 0 to 7. A score of 7 indicates the highest level of fatigue and 1 indicates no fatigue. The patients with above-average scores were considered to have fatigue and those with lower scores were considered to have no fatigue. To analyse the data, descriptive and inferential statistics (chi-square test, one-way ANOVA, and logistic regression) were used. Results: The mean age of the patients was 52.1 ± 14.4 years. The majority of the subjects were women (58.9%), married (91.1%), and with an educational level below diploma (40%). The average score of fatigue was 5.8 ± 0.54 out of 7. The results of the logistic regression model showed that the factors influencing cancer-related fatigue were the variable of unemployment (p =0.034, β= 1.1) and haemoglobin levels (p=0.049, β= 0.33). Conclusion:The results showed that in addition to providing physical care and nursing interventions, it is important to consider demographic factors and psychological interventions for the comprehensive management of problems in cancer patients, particularly fatigue.

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Fatigue in colorectal cancer patients: prevalence and associated factors

Cited by 41 publications

References 25 publications

Displaced Myonuclei in Cancer Cachexia Suggest Altered Innervation

Displaced Myonuclei in Cancer Cachexia Suggest Altered Innervation

Incidence of sleep problems and their mediating role on depression and anxious preoccupation in patients with resected, non-advanced cancer: data from NEOcoping study

The Assessment of Fatigue and its Related Factors in Patients with Cancer

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