Fatigue in Covid-19 survivors: The potential impact of a nutritional supplement on muscle strength and function

Landi, Francesco; Gremese, Elisa; Bernabei, Roberto; Fantoni, M; Gasbarrini, Antonio; Porcari, Serena; Settanni, Carlo Romano; Benvenuto, Francesca; Bramato, Giulia; Brandi, Vincenzo; Carfì, Angelo; Ciciarello, Francesca; Fabrizi, Sofia; Galluzzo, Vincenzo; Monaco, Maria Rita Lo; Martone, Anna Maria; Marzetti, Emanuele; Napolitano, Carmen; Pagano, Francesco; Pais, Cristina; Rocchi, Sara; Rota, Elisabetta; Salerno, Andrea; Tosato, Matteo; Tritto, Marcello; Zazzara, Maria Beatrice; Calvani, Riccardo; Catalano, Lucio; Picca, Anna; Savera, Giulia; Damiano, Francesco Paolo; Rocconi, Alessandra; Galliani, Alessandro; Spaziani, Giovanni; Tupputi, S. A.; Cocchi, Camilla; Pirone, Flavia; D’Ignazio, Federica; Cacciatore, Stefano; Cauda, Roberto; Tamburrini, Enrica; Borghetti, Alberto; Gianbenedetto, Simona Di; Murri, Rita; Cingolani, Antonella; Ventura, G.; Taddei, Eleonora; Moschese, Davide; Ciccullo, Arturo; Dusina, A.; Stella, Leonardo; Addolorato, Giovanni; Franceschi, Francesco; Mingrone, Gertrude; Zocco, Maria Assunta; Sanguinetti, Maurizio; Cattani, Paola; Marchetti, Simona; Posteraro, Brunella; Sali, Michela; Bizzarro, Alessandra; Lauria, Alessandra; Rizzo, Stanislao; Savastano, Maria Cristina; Gambini, Gloria; Cozzupoli, Grazia Maria; Culiersi, Carola; Passàli, Giulio Cesare; Paludetti, Gaetano; Galli, Jacopo; Crudo, Fabrizio; Cintio, Giovanni Di; Longobardi, Y.; Tricarico, Lucia; Santantonio, Mariaconsiglia; Buonsenso, Danilo; Valentini, Piero; Pata, Davide; Sinatti, Dario; Rose, Cristina De; Richeldi, Luca; Lombardi, F.; Calabrese, Angelo; Leone, Paolo Maria; Calvello, Maria Rosaria; Intini, Enrica; Montemurro, Giuliano; Sani, Gabriele; Janiri, Delfina; Simonetti, Alessio; Giuseppin, Giulia; Molinaro, Marzia; odica, M.; Natale, Luigi; Larici, Anna Rita; Marano, Riccardo; Paglionico, Annamaria; Petricca, Luca; Gigante, Luca; Natalello, Gerlando; Fedele, Anna Laura; Lizzio, Marco Maria; Tolusso, Barbara; Mario, Clara Di; Alivernini, Stefano; Santoliquido, Angelo; Santoro, Luca; Giorgio, Angela Di; Nesci, Antonio; Popolla, Valentina

doi:10.1016/j.clnesp.2022.08.029

Cited by 8 publications

(5 citation statements)

References 62 publications

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“…Moreover, occupational doctors have also referred workers experiencing post-COVID syndrome to their general practitioner (GP) or NHS facilities for treatment. Recent studies have shown that daily supplements based on amino acids, minerals, vitamins, and plant extracts may improve fatigue and muscle function [60]. Other treatment options include molecular hydrogen inhalation, hyperbaric oxygen therapy, aerobic training, strengthening exercises, diaphragmatic breathing techniques, and mindfulness training [61].…”

Section: Future Perspectivesmentioning

confidence: 99%

Post-COVID Symptoms in Occupational Cohorts: Effects on Health and Work Ability

Magnavita

Arnesano

Prinzio

et al. 2023

IJERPH

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Post-acute COVID-19 syndrome is frequently observed in workers and has a substantial impact on work ability. We conducted a health promotion program to identify cases of post-COVID syndrome, analyze the distribution of symptoms and their association with work ability. Of the 1422 workers who underwent routine medical examination in 2021, 1378 agreed to participate. Among the latter, 164 had contracted SARS-CoV-2 and 115 (70% of those who were infected) had persistent symptoms. A cluster analysis showed that most of the post-COVID syndrome cases were characterized by sensory disturbances (anosmia and dysgeusia) and fatigue (weakness, fatigability, tiredness). In one-fifth of these cases, additional symptoms included dyspnea, tachycardia, headache, sleep disturbances, anxiety, and muscle aches. Workers with post-COVID were found to have poorer quality sleep, increased fatigue, anxiety, depression, and decreased work ability compared with workers whose symptoms had rapidly disappeared. It is important for the occupational physician to diagnose post-COVID syndrome in the workplace since this condition may require a temporary reduction in work tasks and supportive treatment.

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Section: Future Perspectivesmentioning

confidence: 99%

Post-COVID Symptoms in Occupational Cohorts: Effects on Health and Work Ability

Magnavita

Arnesano

Prinzio

et al. 2023

IJERPH

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“…Furthermore, a recent meta-analysis has shown that the frequency of myalgia and arthralgia in acute COVID-19 is similar between hospitalized and non-hospitalized patients, although the incidence of these symptoms tends to be higher in hospitalized subjects up 60 to 90 days after first viral detection [28]. As seen in those who did not continue to take analgesics in the post-acute phase, we cannot undermine the role of supplements that are often used in long-term management of persistent post-COVID-19 symptoms [11,[29][30][31][32].…”

Section: Discussionmentioning

confidence: 90%

Use of First-Line Oral Analgesics during and after COVID-19: Results from a Survey on a Sample of Italian 696 COVID-19 Survivors with Post-Acute Symptoms

Galluzzo

Zazzara

Ciciarello

et al. 2023

JCM

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Background—Analgesics could be used to manage painful symptoms during and after COVID-19. Materials and methods—Persistence of painful symptoms was assessed during and after COVID-19 in a sample of patients admitted to a post-acute COVID-19 outpatient service in Rome, Italy. Data on type and frequency of use of first-line analgesics were collected. Pain severity was evaluated with a numeric rating scale (NRS) from 0 to 10. Results—Mean age of 696 participants was 57.1 ± 20.3 years and 61.7% were women. During COVID-19, the most prevalent symptoms were fever, fatigue, arthralgia, myalgia and headache. Acetaminophen was used by 40% of the sample. Only 6.7% needed to continue analgesic therapy after COVID-19. Frequent causes of analgesics consumption were persistent arthralgia and myalgia. The most common analgesics used amongst those who continued taking analgesics in the post-acute phase of COVID-19 were the following: acetaminophen (31%), ibuprofen (31%) and other non-steroidal anti-inflammatory drug (NSAID) (29.5%); in older subjects the most common analgesic used was acetaminophen (54%). Most of the subjects in this group said there was an improvement in pain perception after taking analgesic therapy (84%). Conclusions—Use of analgesics in the post-acute COVID-19 is common in subjects with persistent arthralgia and myalgia, and common analgesics were acetaminophen and ibuprofen. Further research on the safety and efficacy of those medications in COVID-19 is warranted.

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“…Most likely, women experience post-acute COVID-19 symptoms more than men [ 21 , 37 ]. Frequently reported Long COVID-19 symptoms are fatigue, dyspnea, and joint-muscle pain [ 38 , 39 , 40 ], which are associated with a reduced tolerance to exercise [ 41 , 42 , 43 ] that may limit physical activity [ 21 , 38 , 44 ].…”

Section: Discussionmentioning

confidence: 99%

Inadequate Physical Activity Is Associated with Worse Physical Function in a Sample of COVID-19 Survivors with Post-Acute Symptoms

Galluzzo

Zazzara

Ciciarello

et al. 2023

JCM

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Background—Patients affected by Long COVID often report shorter times spent doing physical activity (PA) after COVID-19. The aim of the present study was to evaluate potential associations between PA levels and parameters of physical function in a cohort of COVID-19 survivors with post-acute symptoms, with a particular focus on individuals aged 65 and older. Materials and methods—PA levels before and after COVID-19 were assessed in a sample of patients that had recovered from COVID-19 and were admitted to a post-acute outpatient service at the Fondazione Policlinico Universitario Agostino Gemelli IRCCS (Rome, Italy). Participation in PA was operationalized as the engagement in leisure-time PA for at least 150 min per week in the last 3 months. Self-rated health and measures of physical performance and muscle strength were assessed. Results—Mean age of 1846 participants was 55.2 ± 14.4 years and 47% were women. Before COVID-19, inactivity was detected in 47% of the whole study population; only 28% maintained pre-COVID-19 PA engagement. Inactivity was more frequent in women. The stopping of physical activity was associated with increased BMI and CRP levels, lower vitamin D levels and a higher prevalence of post-COVID-19 fatigue, dyspnea, arthralgia, and myalgia. Active participants had higher handgrip strength and performed better on both the six-minute walking test (6MWT) and at the one-minute sit-to-stand test (1MSTST). In particular, at the 6MWT, participants 65 and older that were still active after COVID-19 walked 32 m more than sedentary peers. Moreover, the distance covered was 28 m more than those who were active only before COVID-19 (p = 0.05). Formerly active subjects performed similarly at the 6MWT to inactive participants. PA was associated with better self-rated health. Conclusions—Our findings reveal that inactivity is frequent in the post-acute COVID-19 phase. Stopping physical activity after COVID-19 results in measures of performance that are comparable to those who were never active. Relevant differences in the distance covered at the 6MWT were found between older active subjects and their sedentary peers.

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Fatigue in Covid-19 survivors: The potential impact of a nutritional supplement on muscle strength and function

Cited by 8 publications

References 62 publications

Post-COVID Symptoms in Occupational Cohorts: Effects on Health and Work Ability

Post-COVID Symptoms in Occupational Cohorts: Effects on Health and Work Ability

Use of First-Line Oral Analgesics during and after COVID-19: Results from a Survey on a Sample of Italian 696 COVID-19 Survivors with Post-Acute Symptoms

Inadequate Physical Activity Is Associated with Worse Physical Function in a Sample of COVID-19 Survivors with Post-Acute Symptoms

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